Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Sujata Mahapatra"'
Autor:
Asha P. Shetty, Rashan Haniffa, Nanda Kumar P, Upendra Hansda, Mahalingam V, Alok Kumar Sahoo, Jayanta Kumar Mitra, Sujata Mahapatra, Kasturi Sanyal, P Bhaskar Rao, Guruprasad N, Itimayee Panda, Helen Eborral, Jagannath Sahoo, Nazir Lone, Swagata Tripathy, Abi Beane
Publikováno v:
Wellcome Open Research, Vol 8 (2024)
Background The paucity of state-supported rehabilitation for chronically ill patients with long-term tracheostomies has ramifications of prolonged hospital-stay, increased burden on acute-care resources, and nosocomial infections. Few interventions d
Externí odkaz:
https://doaj.org/article/32548993e298431982dadcf3014024dd
Autor:
Alina Kulakova, Dillen Augustijn, Inas El Bialy, Lorenzo Gentiluomo, Maria Laura Greco, Stefan Hervø-Hansen, Sowmya Indrakumar, Sujata Mahapatra, Marcello Martinez Morales, Christin Pohl, Marco Polimeni, Aisling Roche, Hristo L. Svilenov, Andreas Tosstorff, Matja Zalar, Robin Curtis, Jeremy P. Derrick, Wolfgang Frieß, Alexander P. Golovanov, Mikael Lund, Allan Nørgaard, Tarik A. Khan, Günther H. J. Peters, Alain Pluen, Dierk Roessner, Werner W. Streicher, Christopher F. van der Walle, Jim Warwicker, Shahid Uddin, Gerhard Winter, Jens Thostrup Bukrinski, Åsmund Rinnan, Pernille Harris
Publikováno v:
Molecular Pharmaceutics.
Autor:
Upendra, Hansda, Swagata, Tripathy, Alok Kumar, Sahoo, Itimayee, Panda, Asha P, Shetty, Jayanta Kumar, Mitra, Kasturi, Sanyal, Mahalingam, Venkateshan, Nanda Kumar, Paniyadi, Parnandi Bhaskar, Rao, Sujata, Mahapatra
Publikováno v:
Indian Journal of Critical Care Medicine. 26:577-581
Chronically critically ill (CCI) patients often have high costs of care and poor outcomes. Disease management programs offering home care may reduce costs but need buy-in from informal caregivers. An understanding of caregiver burden in this populati
Autor:
Sujata Mahapatra, Marco Polimeni, Lorenzo Gentiluomo, Dierk Roessner, Wolfgang Frieß, Günther H. J. Peters, Werner W. Streicher, Mikael Lund, Pernille Harris
Publikováno v:
Molecular Pharmaceutics
Using light scattering (LS), small-angle X-ray scattering (SAXS), and coarse-grained Monte Carlo (MC) simulations, we studied the self-interactions of two monoclonal antibodies (mAbs), PPI03 and PPI13. With LS measurements, we obtained the osmotic se
Publikováno v:
Asian Journal of Biological and Life sciences. 10:352-358
Autor:
Werner Streicher, Sujata Mahapatra, Günther H.J. Peters, Allan Nørgaard, Pernille Harris, Christin Pohl, Alina Kulakova
Publikováno v:
Pohl, C, Mahapatra, S, Kulakova, A, Streicher, W, Peters, G H J, Nørgaard, A & Harris, P 2022, ' Combination of high throughput and structural screening to assess protein stability-A screening perspective ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 171 . https://doi.org/10.1016/j.ejpb.2021.08.018
European journal of pharmaceutics and biopharmaceutics 171, 1-10 (2022). doi:10.1016/j.ejpb.2021.08.018
Pohl, C, Mahapatra, S, Kulakova, A, Streicher, W, Peters, G H J, Nørgaard, A & Harris, P 2022, ' Combination of high throughput and structural screening to assess protein stability – A screening perspective ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 171, pp. 1-10 . https://doi.org/10.1016/j.ejpb.2021.08.018
European journal of pharmaceutics and biopharmaceutics 171, 1-10 (2022). doi:10.1016/j.ejpb.2021.08.018
Pohl, C, Mahapatra, S, Kulakova, A, Streicher, W, Peters, G H J, Nørgaard, A & Harris, P 2022, ' Combination of high throughput and structural screening to assess protein stability – A screening perspective ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 171, pp. 1-10 . https://doi.org/10.1016/j.ejpb.2021.08.018
European journal of pharmaceutics and biopharmaceutics 171, 1 - 10 (2022). doi:10.1016/j.ejpb.2021.08.018
High throughput screening for measuring the stability of industrially relevant proteins and their variants is necessary for quality assessm
High throughput screening for measuring the stability of industrially relevant proteins and their variants is necessary for quality assessm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea860997e4adeb3ebbd6a386757edca3
Autor:
Wolfgang Frieß, Dierk Roessner, Lorenzo Gentiluomo, Werner Streicher, Sujata Mahapatra, Pernille Harris
Publikováno v:
Journal of Pharmaceutical Sciences
Gentiluomo, L, Roessner, D, Streicher, W, Mahapatra, S, Harris, P & Frieß, W 2020, ' Characterization of native reversible self-association of a monoclonal antibody mediated by Fab-Fab interaction ', Journal of Pharmaceutical Sciences, vol. 109, no. 1, pp. 443-451 . https://doi.org/10.1016/j.xphs.2019.09.021
Gentiluomo, L, Roessner, D, Streicher, W, Mahapatra, S, Harris, P & Frieß, W 2020, ' Characterization of native reversible self-association of a monoclonal antibody mediated by Fab-Fab interaction ', Journal of Pharmaceutical Sciences, vol. 109, no. 1, pp. 443-451 . https://doi.org/10.1016/j.xphs.2019.09.021
The native reversible self-association of monoclonal antibodies has been associated with high viscosity, liquid-liquid, and liquid-solid phase separation. We investigated the native reversible self-association of an IgG1, which exerts this associatio
Publikováno v:
International Journal of PharmTech Research. 13:172-179
Sustained-release (SR) matrix tablets of Acyclovir and polysaccharide isolated from corms of Colocasia esculenta, at different drug to polymer ratios, were prepared by using wet granulation method. The formulated tablets were also characterized by ph
Autor:
Sowmya Indrakumar, Sujata Mahapatra, Alina Kulakova, Werner Streicher, Günther H.J. Peters, Pernille Harris, Pernille Sønderby Tuelung
Publikováno v:
Scientific reports 10(1), 10089 (2020). doi:10.1038/s41598-020-67002-9
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Kulakova, A, Indrakumar, S, Sønderby Tuelung, P, Mahapatra, S, Streicher, W W, Peters, G H J & Harris, P 2020, ' Albumin-neprilysin fusion protein : understanding stability using small angle X-ray scattering and molecular dynamic simulations ', Scientific Reports, vol. 10, no. 1, 10089 . https://doi.org/10.1038/s41598-020-67002-9
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Kulakova, A, Indrakumar, S, Sønderby Tuelung, P, Mahapatra, S, Streicher, W W, Peters, G H J & Harris, P 2020, ' Albumin-neprilysin fusion protein : understanding stability using small angle X-ray scattering and molecular dynamic simulations ', Scientific Reports, vol. 10, no. 1, 10089 . https://doi.org/10.1038/s41598-020-67002-9
Scientific Reports
Scientific reports 10(1), 10089 (2020). doi:10.1038/s41598-020-67002-9
Fusion technology is widely used in protein-drug development to increase activity, stability, and bioavailability of protein therapeutics. Fusion proteins, like any other typ
Fusion technology is widely used in protein-drug development to increase activity, stability, and bioavailability of protein therapeutics. Fusion proteins, like any other typ
Autor:
Shahid Uddin, Christin Pohl, Christopher F. van der Walle, Inas El Bialy, Jeremy P. Derrick, Andreas Tosstorff, Robin Curtis, Sujata Mahapatra, Werner Streicher, Dillen Augustijn, Aisling Roche, Alina Kulakova, Wolfgang Frieß, Åsmund Rinnan, Hristo L. Svilenov, Dierk Roessner, Lorenzo Gentiluomo, Sowmya Indrakumar, Alain Pluen, Gerhard Winter, Pernille Harris, Allan Nørgaard, Günther H.J. Peters, Maria Laura Greco, Marcello Martinez Morales, Tarik A. Khan
Publikováno v:
Molecular Pharmaceutics
Gentiluomo, L, Svilenov, H L, Augustijn, D, El Bialy, I, Greco, M L, Vitaliyivna Kulakova, A, Indrakumar, S, Mahapatra, S, Morales, M M, Pohl, C, Roche, A, Tosstorff, A, Curtis, R, Derrick, J P, Nørgaard, A, Khan, T A, Peters, G H J, Pluen, A, Rinnan, Å, Streicher, W W, van der Walle, C F, Uddin, S, Winter, G, Roessner, D, Harris, P & Frieß, W 2020, ' Advancing Therapeutic Protein Discovery and Development through Comprehensive Computational and Biophysical Characterization ', Molecular Pharmaceutics, vol. 17, no. 2, pp. 426-440 . https://doi.org/10.1021/acs.molpharmaceut.9b00852
Gentiluomo, L, Svilenov, H L, Augustijn, D, El Bialy, I, Greco, M L, Kulakova, A, Indrakumar, S, Mahapatra, S, Morales, M M, Pohl, C, Roche, A, Tosstorff, A, Curtis, R, Derrick, J P, Nørgaard, A, Khan, T A, Peters, G H J, Pluen, A, Rinnan, Å, Streicher, W W, van der Walle, C F, Uddin, S, Winter, G, Roessner, D, Harris, P & Friess, W 2020, ' Advancing Therapeutic Protein Discovery and Development through Comprehensive Computational and Biophysical Characterization ', Molecular Pharmaceutics, vol. 17, no. 2, pp. 426-440 . https://doi.org/10.1021/acs.molpharmaceut.9b00852
Gentiluomo, L, Svilenov, H L, Augustijn, D, El Bialy, I, Greco, M L, Vitaliyivna Kulakova, A, Indrakumar, S, Mahapatra, S, Morales, M M, Pohl, C, Roche, A, Tosstorff, A, Curtis, R, Derrick, J P, Nørgaard, A, Khan, T A, Peters, G H J, Pluen, A, Rinnan, Å, Streicher, W W, van der Walle, C F, Uddin, S, Winter, G, Roessner, D, Harris, P & Frieß, W 2020, ' Advancing Therapeutic Protein Discovery and Development through Comprehensive Computational and Biophysical Characterization ', Molecular Pharmaceutics, vol. 17, no. 2, pp. 426-440 . https://doi.org/10.1021/acs.molpharmaceut.9b00852
Gentiluomo, L, Svilenov, H L, Augustijn, D, El Bialy, I, Greco, M L, Kulakova, A, Indrakumar, S, Mahapatra, S, Morales, M M, Pohl, C, Roche, A, Tosstorff, A, Curtis, R, Derrick, J P, Nørgaard, A, Khan, T A, Peters, G H J, Pluen, A, Rinnan, Å, Streicher, W W, van der Walle, C F, Uddin, S, Winter, G, Roessner, D, Harris, P & Friess, W 2020, ' Advancing Therapeutic Protein Discovery and Development through Comprehensive Computational and Biophysical Characterization ', Molecular Pharmaceutics, vol. 17, no. 2, pp. 426-440 . https://doi.org/10.1021/acs.molpharmaceut.9b00852
Therapeutic protein candidates should exhibit favorable properties that render them suitable to become drugs. Nevertheless, there are no well-established guidelines for the efficient selection of proteinaceous molecules with desired features during e