Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Sujaan Das"'
Autor:
Madeline G Dans, Henni Piirainen, William Nguyen, Sachin Khurana, Somya Mehra, Zahra Razook, Niall D Geoghegan, Aurelie T Dawson, Sujaan Das, Molly Parkyn Schneider, Thorey K Jonsdottir, Mikha Gabriela, Maria R Gancheva, Christopher J Tonkin, Vanessa Mollard, Christopher Dean Goodman, Geoffrey I McFadden, Danny W Wilson, Kelly L Rogers, Alyssa E Barry, Brendan S Crabb, Tania F de Koning-Ward, Brad E Sleebs, Inari Kursula, Paul R Gilson
Publikováno v:
PLoS Biology, Vol 21, Iss 4, p e3002066 (2023)
With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red blood cell (RBC) invasion, and
Externí odkaz:
https://doaj.org/article/d4ae40a3c3394669ac6efd4a149b5ec0
Multiple essential functions of Plasmodium falciparum actin-1 during malaria blood-stage development
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-16 (2017)
Abstract Background The phylum Apicomplexa includes intracellular parasites causing immense global disease burden, the deadliest of them being the human malaria parasite Plasmodium falciparum, which invades and replicates within erythrocytes. The cyt
Externí odkaz:
https://doaj.org/article/0d776267ac254f208d72aa808e6d9b71
Autor:
Johannes Felix Stortz, Mario Del Rosario, Mirko Singer, Jonathan M Wilkes, Markus Meissner, Sujaan Das
Publikováno v:
eLife, Vol 8 (2019)
In addition to its role in erythrocyte invasion, Plasmodium falciparum actin is implicated in endocytosis, cytokinesis and inheritance of the chloroplast-like organelle called the apicoplast. Previously, the inability to visualise filamentous actin (
Externí odkaz:
https://doaj.org/article/e14157f79b7e4c07948af73c60e026d7
Autor:
James A Thomas, Christine R Collins, Sujaan Das, Fiona Hackett, Arnault Graindorge, Donald Bell, Edgar Deu, Michael J Blackman
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157873 (2016)
Malaria is caused by an obligate intracellular protozoan parasite that replicates within and destroys erythrocytes. Asexual blood stages of the causative agent of the most virulent form of human malaria, Plasmodium falciparum, can be cultivated indef
Externí odkaz:
https://doaj.org/article/ef1099d7b63741d48c252752c1141752
Autor:
Manuela S Pieperhoff, Gurman S Pall, Elena Jiménez-Ruiz, Sujaan Das, Carmen Melatti, Matthew Gow, Eleanor H Wong, Joanne Heng, Sylke Müller, Michael J Blackman, Markus Meissner
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130356 (2015)
The functional characterisation of essential genes in apicomplexan parasites, such as Toxoplasma gondii or Plasmodium falciparum, relies on conditional mutagenesis systems. Here we present a novel strategy based on U1 snRNP-mediated gene silencing. U
Externí odkaz:
https://doaj.org/article/acaad93cffd543fbb349e6c90b019fb4
Autor:
Madeline G. Dans, Henni Piirainen, William Nguyen, Sachin Khurana, Somya Mehra, Zahra Razook, Sujaan Das, Molly Parkyn Schneider, Thorey K. Jonsdottir, Mikha Gabriela, Maria R. Gancheva, Christopher J. Tonkin, Vanessa Mollard, Christopher Dean Goodman, Geoffrey I. McFadden, Danny W. Wilson, Alyssa E. Barry, Brendan S. Crabb, Tania F. de Koning-Ward, Brad E. Sleebs, Inari Kursula, Paul R. Gilson
With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red blood cell invasion, and have g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce01f8df6990aa8f2e44e034dbc1bac0
https://doi.org/10.1101/2022.09.29.510018
https://doi.org/10.1101/2022.09.29.510018
Publikováno v:
Cellular Microbiology. 23
The cytoskeletal protein actin is highly abundant and conserved in eukaryotic cells. It occurs in two different states- the globular (G-actin) form, which can polymerise into the filamentous (F-actin) form, fulfilling various critical functions inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fcbc8630dc7e2033d7fc48e65c919a5
https://doi.org/10.1111/cmi.13345
https://doi.org/10.1111/cmi.13345
Autor:
Isabelle Tardieux, Gurman S. Pall, Jake Baum, Markus Meissner, Oliver Lyth, Javier Periz, Mario Del Rosario, Fernanda Latorre-Barragan, Georgios Pavlou, Jamie Whitelaw, Leandro Lemgruber, Johannes Felix Stortz, Sujaan Das
Publikováno v:
EMBO Reports
The obligate intracellular parasites Toxoplasma gondii and Plasmodium spp. invade host cells by injecting a protein complex into the membrane of the targeted cell that bridges the two cells through the assembly of a ring‐like junction. This circula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf27c95a3e172631da35234c7348dab0
https://doi.org/10.15252/embr.201948896
https://doi.org/10.15252/embr.201948896
Autor:
Mario Del Rosario, Javier Periz, Georgios Pavlou, Oliver Lyth, Fernanda Latorre-Barragan, Sujaan Das, Gurman S. Pall, Johannes Felix Stortz, Leandro Lemgruber, Jake Baum, Isabelle Tardieux, Markus Meissner
The obligate intracellular parasites Toxoplasma gondii and Plasmodium spp. invade host cells by injecting a protein complex into the membrane of the targeted cell that bridges the two cells through the assembly of a ring-like junction. This circular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fa82f3e8fbce0977a18306da7346ea
https://doi.org/10.1101/646463
https://doi.org/10.1101/646463