A3AR antagonism mitigates metabolic dysfunction-associated steatotic liver disease by exploiting monocyte-derived Kupffer cell necroptosis and inflammation resolution

Autor: Park, Jeong-Su ^{a, 1}, Ma, Yuan-Qiang ^{a, 1}, Wang, Feng ^a, Ma, Hwan ^a, Sui, Guoyan ^a, Rustamov, Nodir ^a, Han, Minyeong ^a, Son, Yejin ^a, Park, Chun-Woong ^a, Han, Sang-Bae ^a, Hong, Jin Tae ^a, Jeong, Lak Shin ^{b, c}, Lee, Jin ^{d, ⁎}, Roh, Yoon Seok ^{a, ⁎⁎}

Publikováno v: In Metabolism March 2025 164

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A3AR antagonism mitigates metabolic dysfunction-associated steatotic liver disease by exploiting monocyte-derived Kupffer cell necroptosis and inflammation resolution.

Autor: Park JS; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, South Korea., Ma YQ; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, South Korea., Wang F; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, South Korea., Ma H; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, South Korea., Sui G; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, South Korea., Rustamov N; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, South Korea., Han M; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, South Korea., Son Y; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, South Korea., Park CW; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, South Korea., Han SB; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, South Korea., Hong JT; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, South Korea., Jeong LS; Research and Development Center, Future Medicine Co., Ltd, Seongnam, South Korea; College of Pharmacy, Seoul National University, Seoul, South Korea., Lee J; Department of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: jil327@health.ucsd.edu., Roh YS; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungbuk, South Korea. Electronic address: ysroh@cbnu.ac.kr.

Publikováno v: Metabolism: clinical and experimental [Metabolism] 2024 Dec 26; Vol. 164, pp. 156114. Date of Electronic Publication: 2024 Dec 26.