Výsledky vyhledávání - "Suhyeon Kwon"

De Novo Design, Synthesis, and Mechanistic Evaluation of Short Peptides That Mimic Heat Shock Protein 27 Activity

Autor: Jessica Kho, Suhyeon Kwon, Heath Ecroyd, P Chi Pham, Huixin Wang, Shelli R McAlpine, Alana Y Huang, W Alexander Donald, Joel P Rivers

Publikováno v: ACS Med Chem Lett

[Image: see text] We report the first small molecule peptides based on the N-terminal sequence of heat shock protein 27 (Hsp27, gene HSPB1) that demonstrates chaperone-like activity. The peptide, comprising the SWDPF sequence located at Hsp27’s ami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09a41c52f679fa3069245c265df54d1
https://doi.org/10.1021/acsmedchemlett.0c00609

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Synthesis and Structure–Activity Relationships of Inhibitors That Target the C-Terminal MEEVD on Heat Shock Protein 90

Autor: Shelli R. McAlpine, Samantha S. Zaiter, Lok K. O. Lam, Marwa N. Rahimi, David A. Neale, Gabriel D. Moldovan, Suhyeon Kwon, Jessica Kho, Michael Leong, Gillian Thornton, Jenane Konesan, Vickie Chan, Laura K. Buckton, Michael F. Lawler, Aldwin Guo

Publikováno v: ACS Medicinal Chemistry Letters

Herein, we describe the synthesis and structure–activity relationships of cyclic peptides designed to target heat shock protein 90 (Hsp90). Generating 19 compounds and evaluating their binding affinity reveals that increasing electrostatic interact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d95234de22b1366007e162e32f61d2
https://doi.org/10.1021/acsmedchemlett.7b00310

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