A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation

Autor: Sisi Kang, Mei Yang, Suhua He, Yueming Wang, Xiaoxue Chen, Yao-Qing Chen, Zhongsi Hong, Jing Liu, Guanmin Jiang, Qiuyue Chen, Ziliang Zhou, Zhechong Zhou, Zhaoxia Huang, Xi Huang, Huanhuan He, Weihong Zheng, Hua-Xin Liao, Fei Xiao, Hong Shan, Shoudeng Chen

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

While SARS-CoV-2 S protein targeting monoclonal antibodies (mAbs) are well studied, little is known about N protein-targeting mAbs. Here, Kang et al. provide the crystal structure of the N protein RNA binding domain with a mAb derived from a convales

Externí odkaz: https://doaj.org/article/2da4437eaadf4c83b43c76e7bb299f22

Crystal Structures of Bat and Human Coronavirus ORF8 Protein Ig-Like Domain Provide Insights Into the Diversity of Immune Responses

Autor: Xiaoxue Chen, Zhechong Zhou, Chunliu Huang, Ziliang Zhou, Sisi Kang, Zhaoxia Huang, Guanmin Jiang, Zhongsi Hong, Qiuyue Chen, Mei Yang, Suhua He, Siqi Liu, Jie Chen, Kenan Li, Xin Li, Jing Liao, Jun Chen, Shoudeng Chen

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

ORF8 is a viral immunoglobulin-like (Ig-like) domain protein encoded by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA genome. It tends to evolve rapidly and interfere with immune responses. However, the structural characteristi

Externí odkaz: https://doaj.org/article/46e09fdbadb240efac31ccae33a79b20

Structural insight reveals SARS-CoV-2 ORF7a as an immunomodulating factor for human CD14+ monocytes

Autor: Ziliang Zhou, Chunliu Huang, Zhechong Zhou, Zhaoxia Huang, Lili Su, Sisi Kang, Xiaoxue Chen, Qiuyue Chen, Suhua He, Xia Rong, Fei Xiao, Jun Chen, Shoudeng Chen

Publikováno v: iScience, Vol 24, Iss 3, Pp 102187- (2021)

Summary: Dysregulated immune cell responses have been linked to the severity of coronavirus disease 2019 (COVID-19), but the specific viral factors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were currently unknown. Herein, we rev

Externí odkaz: https://doaj.org/article/05343feddc654e118c5cdd12f2412f7a

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

Autor: Zhaoxia Huang, Sisi Kang, Mei Yang, Hong Shan, Yan Yan, Zhechong Zhou, Ziliang Zhou, Changsheng Zhang, Shoudeng Chen, Qiuyue Chen, Suhua He, Liping Zhang, Xiaoxue Chen, Zhongsi Hong

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 7, Pp 1228-1238 (2020)
Acta pharmaceutica Sinica, 10(7):1228-1238
Acta Pharmaceutica Sinica B

The outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus continually led to worldwide human infections and deaths. Currently, there is no specific viral protein-targeted therapeutics. Viral nucleocapsid protein is a potential antivir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b94c32fa5af878268e35f091d21fe3f
https://doi.org/10.1016/j.apsb.2020.04.009

A COVID-19 antibody curbs SARS-CoV-2 nucleocapsid protein-induced complement hyperactivation

Autor: Qiuyue Chen, Ziliang Zhou, Yao-Qing Chen, Jing Liu, Zheng Weihong, Huanhuan He, Fei Xiao, Xi Huang, Mei Yang, Guanmin Jiang, Zhechong Zhou, Hong Shan, Wang Yueming, Zhaoxia Huang, Xiaoxue Chen, Sisi Kang, Hua-Xin Liao, Shoudeng Chen, Zhongsi Hong, Suhua He

Although human antibodies elicited by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein are profoundly boosted upon infection, little is known about the function of N-reactive antibodies. Herein, we isolated an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::971d537899ea0263bc8f2e684e8f0f58
https://doi.org/10.21203/rs.3.rs-106760/v1