Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Suhita Nadkarni"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010334 (2022)
Accumulation of amyloid-beta (Aβ) is associated with synaptic dysfunction and destabilization of astrocytic calcium homeostasis. A growing body of evidence support astrocytes as active modulators of synaptic transmission via calcium-mediated gliotra
Externí odkaz:
https://doaj.org/article/ae84aac4eb4f4d3ba8ad5fdc5cfb3fc5
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Singh and colleagues report that the endoplasmic reticulum (ER) contributes to short-term plasticity (STP). Using modelling approaches they reveal that ER’s buffering capacities are crucial in this process.
Externí odkaz:
https://doaj.org/article/ec509812962c4596977820c84d36183e
Autor:
Shekhar Kedia, Pratyush Ramakrishna, Pallavi Rao Netrakanti, Nivedita Singh, Sangram S. Sisodia, Mini Jose, Sathish Kumar, Anita Mahadevan, Narendrakumar Ramanan, Suhita Nadkarni, Deepak Nair
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101924- (2021)
Summary: Despite intuitive insights into differential proteolysis of amyloid precursor protein (APP), the stochasticity behind local product formation through amyloidogenic pathway at individual synapses remain unclear. Here, we show that the major c
Externí odkaz:
https://doaj.org/article/21e9d9ab34304580affe364f9c950649
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/fde6283603874524aff3920350d8d0ac
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 11, p e1000983 (2010)
We study local calcium dynamics leading to a vesicle fusion in a stochastic, and spatially explicit, biophysical model of the CA3-CA1 presynaptic bouton. The kinetic model for vesicle release has two calcium sensors, a sensor for fast synchronous rel
Externí odkaz:
https://doaj.org/article/aa3b9a63ca9f4d03a93707263ee6b526
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 6 (2008)
Externí odkaz:
https://doaj.org/article/7ede2fc3ce934d839b4d0d2bc0825835
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 5, p e1000088 (2008)
Chemical synapses transmit information via the release of neurotransmitter-filled vesicles from the presynaptic terminal. Using computational modeling, we predict that the limited availability of neurotransmitter resources in combination with the spo
Externí odkaz:
https://doaj.org/article/820226e499e547bca2cd8b919e014179
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology
Communications Biology
Short-term plasticity preserves a brief history of synaptic activity that is communicated to the postsynaptic neuron. This is primarily regulated by a calcium signal initiated by voltage dependent calcium channels in the presynaptic terminal. Imaging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054a58717bb99c82f557643e38173d5a
https://doaj.org/article/ec509812962c4596977820c84d36183e
https://doaj.org/article/ec509812962c4596977820c84d36183e
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848b2e3472020f464f014479ee544108
https://doi.org/10.1038/s42003-021-02519-x
https://doi.org/10.1038/s42003-021-02519-x
Autor:
Gaurang Mahajan, Suhita Nadkarni
Publikováno v:
The Journal of Physiology
Key points Calcium (Ca2+) entry mediated by NMDA receptors is considered central to the induction of activity‐dependent synaptic plasticity in hippocampal area CA1; this description does not, however, take into account the potential contribution of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdff15ab270d070b0afb18908d2db238
https://doi.org/10.1113/jp277726
https://doi.org/10.1113/jp277726