Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Suhas S. Kharat"'
Autor:
Arun Prakash Mishra, Suzanne Hartford, Rajani Kant Chittela, Sounak Sahu, Suhas S. Kharat, Lucia Alvaro-Aranda, Aida Contreras-Perez, Teresa Sullivan, Betty K. Martin, Mary Albaugh, Eileen Southon, Sandra Burkett, Baktiar Karim, Aura Carreira, Lino Tessarollo, Shyam K. Sharan
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-10 (2023)
Abstract Pathogenic variants in BRCA2 are known to significantly increase the lifetime risk of developing breast and ovarian cancers. Sequencing-based genetic testing has resulted in the identification of thousands of BRCA2 variants that are consider
Externí odkaz:
https://doaj.org/article/4d910d29476842d0a246d375382720ea
Autor:
Ramona N. Moro, Uddipta Biswas, Suhas S. Kharat, Filip D. Duzanic, Prosun Das, Maria Stavrou, Maria C. Raso, Raimundo Freire, Arnab Ray Chaudhuri, Shyam K. Sharan, Lorenza Penengo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract DNA replication and repair defects or genotoxic treatments trigger interferon (IFN)-mediated inflammatory responses. However, whether and how IFN signaling in turn impacts the DNA replication process has remained elusive. Here we show that b
Externí odkaz:
https://doaj.org/article/64183fd52790466eb0edc4131fa2fe97
Autor:
Suhas S. Kharat, Shyam K. Sharan
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 6 (2020)
Chemoresistance remains to be a common and significant hurdle with all chemotherapies. Tumors gain resistance by acquiring additional mutations. Some of the chemoresistance mechanisms are known and can be tackled. However, the majority of chemoresist
Externí odkaz:
https://doaj.org/article/7386bd3e3bbf4ac2b8d503add16239ec
Autor:
Uddipta Biswas, Ramona N. Moro, Suhas S. Kharat, Prosun Das, Arnab Ray Chaudhuri, Shyam K. Sharan, Lorenza Penengo
DNA replication and repair defects or genotoxic treatments trigger interferon (IFN)-mediated inflammatory responses. However, whether and how IFN signaling in turn impacts the DNA replication process has remained elusive. Here we show that IFN promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fd1cd4ce56b37ca6e1da138aebf86b1
https://doi.org/10.1101/2023.03.16.533020
https://doi.org/10.1101/2023.03.16.533020
Autor:
Scott E. Martin, Xia Ding, Stephen D. Fox, Chinmayi Pamala, Divya Swaminathan, Kathrin Muegge, Suhas S. Kharat, Akshey Suresh, Hanna Marks, Sandra Burkett, Eugen Buehler, Yafeng He, Manish Singh, Shyam K. Sharan, Satheesh Kumar Sengodan
Publikováno v:
Sci Signal
Synthetic lethality between poly(ADP-ribose) polymerase (PARP) inhibition and BRCA deficiency is exploited to treat breast and ovarian tumors. However, resistance to PARP inhibitors (PARPi) is common. To identify potential resistance mechanisms, we p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ac9105463183cacc58eccdd925383f
https://doi.org/10.1126/scisignal.aba8091
https://doi.org/10.1126/scisignal.aba8091
Autor:
Shyam K. Sharan, Suhas S. Kharat
Publikováno v:
Molecular & Cellular Oncology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Chemoresistance remains to be a common and significant hurdle with all chemotherapies. Tumors gain resistance by acquiring additional mutations. Some of the chemoresistance mechanisms are known and can be tackled. However, the majority of chemoresist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6d3b3f48229093a3a470a27bae462b
https://doi.org/10.1080/23723556.2020.1827904
https://doi.org/10.1080/23723556.2020.1827904
Autor:
Blee, Alexandra M, Gallagher, Kaitlyn S, Kim, Hyun-Suk, Kim, Mihyun, Kharat, Suhas S, Troll, Christina R, D'Souza, Areetha, Park, Jiyoung, Neufer, P Drew, Schärer, Orlando D, Chazin, Walter J
Publikováno v:
NAR Cancer; Mar2024, Vol. 6 Issue 1, p1-15, 15p
Autor:
Mishra, Arun Prakash, Hartford, Suzanne, Chittela, Rajani Kant, Sahu, Sounak, Kharat, Suhas S., Alvaro-Aranda, Lucia, Contreras-Perez, Aida, Sullivan, Teresa, Martin, Betty K., Albaugh, Mary, Southon, Eileen, Burkett, Sandra, Karim, Baktiar, Carreira, Aura, Tessarollo, Lino, Sharan, Shyam K.
Publikováno v:
Cell Death & Disease; Nov2023, Vol. 14 Issue 11, p1-10, 10p
Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15.
Autor:
Moro, Ramona N., Biswas, Uddipta, Kharat, Suhas S., Duzanic, Filip D., Das, Prosun, Stavrou, Maria, Raso, Maria C., Freire, Raimundo, Chaudhuri, Arnab Ray, Sharan, Shyam K., Penengo, Lorenza
Publikováno v:
Nature Communications; 10/2/2023, Vol. 14 Issue 1, p1-15, 15p
Publikováno v:
Women's Health Weekly; 5/24/2024, p510-510, 1p