Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Suharsh Shah"'
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Akademický článek
Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells
Autor: Mahmoud M. Mostafa, Christopher F. Rider, Suharsh Shah, Suzanne L. Traves, Paul M. K. Gordon, Anna Miller-Larsson, Richard Leigh, Robert Newton
Publikováno v: BMC Medical Genomics, Vol 12, Iss 1, Pp 1-21 (2019)
Abstract Background Glucocorticoids act on the glucocorticoid receptor (GR; NR3C1) to resolve inflammation and, as inhaled corticosteroids (ICS), are the cornerstone of treatment for asthma. However, reduced efficacy in severe disease or exacerbation
Externí odkaz: https://doaj.org/article/1a9e7ea088084058a8db7840158c236d
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2
Akademický článek
Cytokine-induced loss of glucocorticoid function: effect of kinase inhibitors, long-acting β(2)-adrenoceptor [corrected] agonist and glucocorticoid receptor ligands.
Autor: Christopher F Rider, Suharsh Shah, Anna Miller-Larsson, Mark A Giembycz, Robert Newton
Publikováno v: PLoS ONE, Vol 10, Iss 1, p e0116773 (2015)
Acting on the glucocorticoid receptor (NR3C1), glucocorticoids are widely used to treat inflammatory diseases. However, glucocorticoid resistance often leads to suboptimal asthma control. Since glucocorticoid-induced gene expression contributes to gl
Externí odkaz: https://doaj.org/article/75f36970dae643a6844edc1126f14280
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6
Additional file 12: of Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells
Autor: Mostafa, Mahmoud, Rider, Christopher, Suharsh Shah, Traves, Suzanne, Gordon, Paul, Miller-Larsson, Anna, Leigh, Richard, Newton, Robert
Commonalities between GO terms enriched with budesonide-repressed (≤0.5 fold, P ≤ 0.05) genes in A549, BEAS-2B and HBE cells using the lower (≤0.8 fold) stringency cut-off between cell variants. The 425 budesonide-repressed genes, as defined in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa0266c31e507952065d12c311e5914
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7
Additional file 6: of Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells
Autor: Mostafa, Mahmoud, Rider, Christopher, Suharsh Shah, Traves, Suzanne, Gordon, Paul, Miller-Larsson, Anna, Leigh, Richard, Newton, Robert
Validation of budesonide-induced genes grouped by fold ≥1.25 cut-off. Figure 3b defines 7 groups, representing overlaps and unique genes (≥ 1.25 fold cut-off) within the 410 genes that were induced ≥2 fold (P ≤ 0.05) by budesonide in the thre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5460a6fdd495b2a4291e9baed41f15
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8
Additional file 2: of Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells
Autor: Mostafa, Mahmoud, Rider, Christopher, Suharsh Shah, Traves, Suzanne, Gordon, Paul, Miller-Larsson, Anna, Leigh, Richard, Newton, Robert
Concentration-dependent induction of gene expression by budesonide in primary human bronchial epithelial (HBE) cells. Primary HBE cells were either not treated or treated with the indicated concentrations of budesonide. After 6 h, cells were harveste
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808ea5afe9a3abff8579b681b43ed93a
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9
DUSP1 Maintains IRF1 and Leads to Increased Expression of IRF1-dependent Genes
Autor: Suharsh Shah, Mahmoud M. Mostafa, Mohammed O. Altonsy, Elizabeth M. King, Robert Newton
Publikováno v: Journal of Biological Chemistry. 291:21802-21816
Although the mitogen-activated protein kinase (MAPK) phosphatase, DUSP1, mediates dexamethasone-induced repression of MAPKs, 14 of 46 interleukin-1β (IL1B)-induced mRNAs were significantly enhanced by DUSP1 overexpression in pulmonary A549 cells. Th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6e0f6c6730dfa3ce8231b2e21b3e273
https://doi.org/10.1074/jbc.m116.728964
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10
Negative Feed-forward Control of Tumor Necrosis Factor (TNF) by Tristetraprolin (ZFP36) Is Limited by the Mitogen-activated Protein Kinase Phosphatase, Dual-specificity Phosphatase 1 (DUSP1)
Autor: Andrew McWhae, Mahmoud M. Mostafa, Suharsh Shah, Suzanne L. Traves, Robert Newton
Publikováno v: Journal of Biological Chemistry. 291:110-125
TNF is central to inflammation and may play a role in the pathogenesis of asthma. The 3'-untranslated region of the TNF transcript contains AU-rich elements (AREs) that are targeted by the RNA-binding protein, tristetraprolin (also known as zinc fing
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10a30f8c7647b4d34d4c73681ac67e0b
https://doi.org/10.1074/jbc.m115.697599
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