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Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60

Autor: Shruthi Hamsanathan, Tamil Anthonymuthu, Suhao Han, Himaly Shinglot, Ella Siefken, Austin Sims, Payel Sen, Hannah L. Pepper, Nathaniel W. Snyder, Hulya Bayir, Valerian Kagan, Aditi U. Gurkar

Publikováno v: Science advances. 8(7)

Although DNA damage is intricately linked to metabolism, the metabolic alterations that occur in response to DNA damage are not well understood. We use a DNA repair–deficient model of ERCC1-XPF in Caenorhabditis elegans to gain insights on how geno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33218314b697ffcf01bfb381e61364c
https://pubmed.ncbi.nlm.nih.gov/35171671

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Analysis of representative mutants for key DNA repair pathways on healthspan in Caenorhabditis elegans

Autor: Roshan Karthikappallil, Himaly Shinglot, Lucile Marchal, Suhao Han, Shruthi Hamsanathan, Aditi U. Gurkar

Publikováno v: Mech Ageing Dev

Although the link between DNA damage and aging is well accepted, the role of different DNA repair proteins on functional/physiological aging is not well-defined. Here, using Caenorhabditis elegans, we systematically examined the effect of three DNA r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f66893755b4a33daa1edbeba3a43b4
https://pubmed.ncbi.nlm.nih.gov/34562508

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Isolation and characterization of a naturally occurring multidrug-resistant strain of the canine hookworm, Ancylostoma caninum

Autor: Olivia G. Granger, Ramesh Ratnappan, Damien M. O'Halloran, Shannon M Kitchen, Caitlyn Leasure, Suhao Han, John M. Hawdon, Emilia Grill, Zahra Iqbal

Publikováno v: International journal for parasitology. 49(5)

Soil-transmitted nematodes infect over a billion people and place several billion more at risk of infection. Hookworm disease is the most significant of these soil-transmitted nematodes, with over 500 million people infected. Hookworm infection can r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe590701be30ca133924699e87498a65
https://pubmed.ncbi.nlm.nih.gov/30771359

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Akademický článek

Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60.

Autor: Hamsanathan, Shruthi¹, Anthonymuthu, Tamil^2,3,4, Suhao Han¹, Shinglot, Himaly¹, Siefken, Ella¹, Sims, Austin¹, Sen, Payel⁵, Pepper, Hannah L.⁶, Snyder, Nathaniel W.⁶, Bayir, Hulya^2,3,7, Kagan, Valerian^3,7, Gurkar, Aditi U.^1,8,9 agurkar1@pitt.edu

Publikováno v: Science Advances. 2/18/2022, Vol. 8 Issue 7, p1-18. 18p.

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