Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Suguru Komenoi"'
Autor:
Suguru Komenoi, Yuji Suzuki, Maho Asami, Chiaki Murakami, Fumi Hoshino, Sohei Chiba, Daisuke Takahashi, Sayaka Kado, Fumio Sakane
Publikováno v:
Biochemistry and Biophysics Reports, Vol 19, Iss , Pp - (2019)
We have revealed that diacylglycerol kinase η (DGKη)-knockout (KO) mice display bipolar disorder (BPD) remedy-sensitive mania-like behaviors. However, the molecular mechanisms causing the mania-like abnormal behaviors remain unclear. In the present
Externí odkaz:
https://doaj.org/article/7e399a45b8fe4a0a98a1a25cf0605444
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 4 (2016)
Ten mammalian diacylglycerol kinase (DGK) isozymes (alpha–kappa) have been identified to date. Our previous review noted that several DGK isozymes can serve as potential drug targets for cancer, epilepsy, autoimmunity, cardiac hypertrophy, hyperten
Externí odkaz:
https://doaj.org/article/f4a9b259ef264aa2866af0cf1dc8be35
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162997 (2016)
Diacylglycerol kinase (DGK) phosphorylates DG to generate phosphatidic acid. Recently, we found that a new alternative splicing product of the DGKη gene, DGKη3, which lacks exon 26 encoding 31 amino acid residues, was expressed only in the secondar
Externí odkaz:
https://doaj.org/article/5ee3a64715514d7494623048fb99d8d0
Autor:
Daisuke Takahashi, Chiaki Murakami, Fumi Hoshino, Fumio Sakane, Suguru Komenoi, Yuji Suzuki, Sayaka Kado, Maho Asami, Sohei Chiba
Publikováno v:
Biochemistry and Biophysics Reports, Vol 19, Iss, Pp-(2019)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
We have revealed that diacylglycerol kinase η (DGKη)-knockout (KO) mice display bipolar disorder (BPD) remedy-sensitive mania-like behaviors. However, the molecular mechanisms causing the mania-like abnormal behaviors remain unclear. In the present
Publikováno v:
Biochemical and Biophysical Research Communications. 497:1031-1037
We previously reported that brain-specific diacylglycerol kinase (DGK) δ-knockout (KO) mice showed obsessive-compulsive disorder (OCD)-like behaviors, which were alleviated by a serotonin (5-HT) transporter (SERT) inhibitor. However, the molecular m
Publikováno v:
Biochemistry and Biophysics Reports
A variety of diacylglycerol (DG) molecular species are produced in stimulated cells. Conventional (α, βII and γ) and novel (δ, ε, η and θ) protein kinase C (PKC) isoforms are known to be activated by DG. However, a comprehensive analysis has n
Autor:
Fumio Sakane, Daisuke Matsutomo, Takako Usuki, Kana Bando, Qiang Lu, Shuntaro Tomokata, Suguru Komenoi, Hiromichi Sakai, Hiroshi Kiyonari, Takeshi Isozaki
Publikováno v:
Journal of neurochemistry. 138(3)
The η isozyme of diacylglycerol kinase (DGK) is highly expressed in the hippocampus and Purkinje cells in the central nervous system. Recently, several genome-wide association studies have implicated DGKη in the etiology of bipolar disorder (BPD).
Autor:
Fumio Sakane, Ena Takeshita, Suguru Komenoi, Hiromichi Sakai, Koki Kawase, Takako Usuki, Aiko Kume
Publikováno v:
The Journal of biological chemistry. 291(15)
Type II diacylglycerol kinase (DGK) isozymes (δ, η, and κ) have a pleckstrin homology domain (PH) at their N termini. Here, we investigated the lipid binding properties of the PHs of type II DGK isozymes using protein-lipid overlay and liposome bi
Publikováno v:
BMC Developmental Biology
Background We have revealed that the type II diacylglycerol kinases (DGKs) δ, η and κ were expressed in the testis and ovary. However, these enzymes’ functions in the reproductive organs remain unknown. Results In this study, we first identified
Publikováno v:
FEBS letters. 589(11)
Diacylglycerol kinase (DGK) η plays important roles in various patho-physiological events such as oncogenesis. In this study, we performed an enzymological characterization of DGKη splice variant 1 (DGKη1). The Km value for diacylglycerol was 0.14