Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis

Autor: Kazuyoshi, Ishigaki, Saori, Sakaue, Chikashi, Terao, Yang, Luo, Kyuto, Sonehara, Kensuke, Yamaguchi, Tiffany, Amariuta, Chun Lai, Too, Vincent A, Laufer, Ian C, Scott, Sebastien, Viatte, Meiko, Takahashi, Koichiro, Ohmura, Akira, Murasawa, Motomu, Hashimoto, Hiromu, Ito, Mohammed, Hammoudeh, Samar Al, Emadi, Basel K, Masri, Hussein, Halabi, Humeira, Badsha, Imad W, Uthman, Xin, Wu, Li, Lin, Ting, Li, Darren, Plant, Anne, Barton, Gisela, Orozco, Suzanne M M, Verstappen, John, Bowes, Alexander J, MacGregor, Suguru, Honda, Masaru, Koido, Kohei, Tomizuka, Yoichiro, Kamatani, Hiroaki, Tanaka, Eiichi, Tanaka, Akari, Suzuki, Yuichi, Maeda, Kenichi, Yamamoto, Satoru, Miyawaki, Gang, Xie, Jinyi, Zhang, Christopher I, Amos, Edward, Keystone, Gertjan, Wolbink, Irene, van der Horst-Bruinsma, Jing, Cui, Katherine P, Liao, Robert J, Carroll, Hye-Soon, Lee, So-Young, Bang, Katherine A, Siminovitch, Niek, de Vries, Lars, Alfredsson, Solbritt, Rantapää-Dahlqvist, Elizabeth W, Karlson, Sang-Cheol, Bae, Robert P, Kimberly, Jeffrey C, Edberg, Xavier, Mariette, Tom, Huizinga, Philippe, Dieudé, Matthias, Schneider, Martin, Kerick, Joshua C, Denny, Koichi, Matsuda, Keitaro, Matsuo, Tsuneyo, Mimori, Fumihiko, Matsuda, Keishi, Fujio, Yoshiya, Tanaka, Atsushi, Kumanogoh, Matthew, Traylor, Cathryn M, Lewis, Stephen, Eyre, Huji, Xu, Richa, Saxena, Thurayya, Arayssi, Yuta, Kochi, Katsunori, Ikari, Masayoshi, Harigai, Peter K, Gregersen, Kazuhiko, Yamamoto, S, Louis Bridges, Leonid, Padyukov, Javier, Martin, Lars, Klareskog, Yukinori, Okada, Soumya, Raychaudhuri

Publikováno v: Nature Genetics, 54, 1640-1651
The Biobank Japan Project 2022, ' Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis ', Nature Genetics, vol. 54, no. 11, pp. 1640-1651 . https://doi.org/10.1038/s41588-022-01213-w
Nature genetics, 54(11), 1640-1651. Nature Publishing Group
Nature Genetics, 54(11), 1640-+. NATURE PORTFOLIO
Nature Genetics, 54(11), 1640-1651. Nature Publishing Group
Nature Genetics, 54, 11, pp. 1640-1651
Nat Genet

Multi-ancestry genome-wide association analyses identify 124 risk loci for rheumatoid arthritis, of which 34 are novel. A polygenic risk score based on multi-ancestry data showed comparable performance between populations of European and East Asian a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e48733cf2e8205acbde830a39b0265
https://doi.org/10.1038/s41588-022-01213-w

Association of Polygenic Risk Scores With Radiographic Progression in Patients With Rheumatoid Arthritis

Autor: Suguru Honda, Katsunori Ikari, Koichiro Yano, Chikashi Terao, Eiichi Tanaka, Masayoshi Harigai, Yuta Kochi

Publikováno v: Arthritis & Rheumatology. 74:791-800

To investigate whether polygenic risk scores obtained using data from a genome-wide association study (GWAS) of rheumatoid arthritis (RA) susceptibility can be predictors of radiographic progression.We constructed polygenic risk scores using GWAS sum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bab026800713377456d8aac027a6eb9
https://doi.org/10.1002/art.42051

Development of a scoring model for the Sharp/van der Heijde score using convolutional neural networks and its clinical application in predicting radiographic progression using a graph convolutional network

Autor: Suguru Honda, Koichiro Yano, Eiichi Tanaka, Katsunori Ikari, Masayoshi Harigai

ObjectiveTo construct a predictive model for the Sharp/van der Heijde score (SHS) and assess its applicability in clinical research settings.MethodsFirst, we built a rheumatoid arthritis (RA) image database linked to clinical information. We then con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b244aa6bf3efbe454876ab36eaf58e4e
https://doi.org/10.1101/2022.06.08.22276135

Selectivity of Janus Kinase Inhibitors in Rheumatoid Arthritis and Other Immune-Mediated Inflammatory Diseases: Is Expectation the Root of All Headache?

Autor: Masayoshi Harigai, Suguru Honda

Publikováno v: Drugs

Janus kinase (JAK) is a signal transducer and activator of a protein transcription system that transduces signals from cell surface cytokine and growth factor receptors to the nucleus. Recently developed JAK inhibitors (JAKinibs) inhibit JAKs non-sel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010a719a8acc8f4a1db4a8b2ba9698a8
http://europepmc.org/articles/PMC7395017

Azathioprine Monotherapy for the Cases of Immunoglobulin G4-Related Disease With Contraindications to Glucocorticoids

Autor: Suguru Honda, Hideyuki Iwai, Takashi Ito, Shinsuke Yasuda, Yusuke Matsuo, Yuka Hirota, Hisanori Hasegawa, Seiji Noda, Hitoshi Kohsaka, Naoki Kimura

Publikováno v: Journal of clinical rheumatology : practical reports on rheumaticmusculoskeletal diseases. 27(8S)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57aa8ec26b842238f9c9a0a0a93b2302
https://pubmed.ncbi.nlm.nih.gov/33998782