Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Sugunavathi Sepramaniam"'
Autor:
Amanpreet Kaur, Jun Yi Stanley Lim, Sugunavathi Sepramaniam, Siddhi Patnaik, Nathan Harmston, May Ann Lee, Enrico Petretto, David M Virshup, Babita Madan
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp n/a-n/a (2021)
Abstract Wnt signaling maintains diverse adult stem cell compartments and is implicated in chemotherapy resistance in cancer. PORCN inhibitors that block Wnt secretion have proven effective in Wnt‐addicted preclinical cancer models and are in clini
Externí odkaz:
https://doaj.org/article/e6cc94805b174024ac08e91805f362b0
Autor:
Prameet Kaur, Jun Rong Tan, Dwi Setyowati Karolina, Sugunavathi Sepramaniam, Arunmozhiarasi Armugam, Tsun-Hon Peter Wong, Kandiah Jeyaseelan
Publikováno v:
Data in Brief, Vol 7, Iss , Pp 381-385 (2016)
Long non-coding RNAs and microRNAs control gene expression to determine central nervous system development and function. Neuronal growth regulator 1 (NEGR1) is a cell adhesion molecule that plays an important role in neurite outgrowth during neuronal
Externí odkaz:
https://doaj.org/article/45dea27bc5764816928d639641ce6db1
Autor:
Sugunavathi Sepramaniam, Jun-Rong Tan, Kay-Sin Tan, Deidre Ann DeSilva, Subramaniam Tavintharan, Fung-Peng Woon, Chee-Woon Wang, Fung-Lin Yong, Dwi-Setyowati Karolina, Prameet Kaur, Fu-Jia Liu, Kai-Ying Lim, Arunmozhiarasi Armugam, Kandiah Jeyaseelan
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 1, Pp 1418-1432 (2014)
MicroRNAs have been identified as key regulators of gene expression and thus their potential in disease diagnostics, prognosis and therapy is being actively pursued. Deregulation of microRNAs in cerebral pathogenesis has been reported to a limited ex
Externí odkaz:
https://doaj.org/article/2ba3a8b0d87349ecb8c76f0ea52aa727
Autor:
Fujia Liu, Jun Rong Tan, Kai Ying Lim, Sugunavathi Sepramaniam, Dwi Setyowati Karolina, Arunmozhiarasi Armugam, Kandiah Jeyaseelan, Prameet Kaur
Publikováno v:
Brain Sciences, Vol 3, Iss 1, Pp 360-395 (2013)
Over the past decade, scientific discoveries have highlighted new roles for a unique class of non-coding RNAs. Transcribed from the genome, these non-coding RNAs have been implicated in determining the biological complexity seen in mammals by acting
Externí odkaz:
https://doaj.org/article/edb5f0cf592e416c8d9b7a66d60dd08b
Autor:
Fu Jia Liu, Prameet Kaur, Dwi S Karolina, Sugunavathi Sepramaniam, Arunmozhiarasi Armugam, Peter T H Wong, Kandiah Jeyaseelan
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128432 (2015)
Hypoxia inducible factor-1α facilitates cellular adaptation to hypoxic conditions. Hence its tight regulation is crucial in hypoxia related diseases such as cerebral ischemia. Changes in hypoxia inducible factor-1α expression upon cerebral ischemia
Externí odkaz:
https://doaj.org/article/38dac6c4807242e2b98213dbb4bd0ec0
Autor:
Prameet Kaur, Dwi Setyowati Karolina, Sugunavathi Sepramaniam, Arunmozhiarasi Armugam, Kandiah Jeyaseelan
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103525 (2014)
Neuronal development is a pro-survival process that involves neurite growth, synaptogenesis, synaptic and neuronal pruning. During development, these processes can be controlled by temporal gene expression that is orchestrated by both long non-coding
Externí odkaz:
https://doaj.org/article/eac1ae33de664a588e536d18e3bc84db
Autor:
Fu Jia Liu, Kai Ying Lim, Prameet Kaur, Sugunavathi Sepramaniam, Arunmozhiarasi Armugam, Peter Tsun Hon Wong, Kandiah Jeyaseelan
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66393 (2013)
To date, miRNA expression studies on cerebral ischemia in both human and animal models have focused mainly on acute phase of ischemic stroke. In this study, we present the roles played by microRNAs in the spontaneous recovery phases in cerebral ische
Externí odkaz:
https://doaj.org/article/740bc7eca999490e9af688f6e50a3803
Autor:
Paul A Tambyah, Sugunavathi Sepramaniam, Jaminah Mohamed Ali, Siaw Ching Chai, Priyadharshini Swaminathan, Arunmozhiarasi Armugam, Kandiah Jeyaseelan
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76811 (2013)
Changes in microRNA expression have been detected in vitro in influenza infected cells, yet little is known about them in patients. microRNA profiling was performed on whole blood of H1N1 patients to identify signature microRNAs to better understand
Externí odkaz:
https://doaj.org/article/2ed49e1db6114ee4a995fdf67fde75a4
Autor:
Kay Sin Tan, Arunmozhiarasi Armugam, Sugunavathi Sepramaniam, Kai Ying Lim, Karolina Dwi Setyowati, Chee Woon Wang, Kandiah Jeyaseelan
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7689 (2009)
BACKGROUND: The methods currently available for diagnosis and prognosis of cerebral ischaemia still require further improvements. Micro-RNAs (small non-coding RNAs) have been recently reported as useful biomarkers in diseases such as cancer and diabe
Externí odkaz:
https://doaj.org/article/e88b200d1b704dc78e03ac1f1f5c780b
Autor:
Zheng Zhong, David M. Virshup, Babita Madan, Kris C. Wood, Xin Hui Chew, Sugunavathi Sepramaniam, May Ann Lee
Publikováno v:
Oncogene
Pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC) is aggressive and lethal. Although there is an urgent need for effective therapeutics in treating pancreatic cancer, none of the targeted therapies tested in clinical trials to date significa