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Local QSAR based on quantum chemistry calculations for the stability of nitrenium ions to reduce false positive outcomes from standard QSAR systems for the mutagenicity of primary aromatic amines.

Autor: Muto S; Translational Research Division, Chugai Pharmaceutical Co., Ltd., 216-Banchi Totsuka-Cho, Totsuka-Ku, Yokohama, Kanagawa, 244-8602, Japan., Furuhama A; Division of Genome Safety Science, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-Ku, Kawasaki, Kanagawa, 210-9501, Japan., Yamamoto M; Non-Clinical Biomedical Science, Applied Research & Operations, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba-Shi, Ibaraki, 305-8585, Japan., Otagiri Y; Human Translational Research Group, EA Pharma Co., Ltd., 2-1-1 Irifune, Chuo-Ku, Tokyo, 104-0042, Japan., Koyama N; Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba-Shi, Ibaraki, 300-2635, Japan., Hitaoka S; Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba-Shi, Ibaraki, 300-2635, Japan., Nagato Y; Toyama Research and Development Center, FUJIFILM Toyama Chemical Co., Ltd., 4-1, Shimookui 2-Chome, Toyama, 930-8508, Japan., Ouchi H; Toxicology Research Lab., Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-13-2 Fukuura, Kanazawa-Ku, Yokohama, Kanagawa, 236-0004, Japan., Ogawa M; Life Science Research Institute, Kumiai Chemical Industry Co., Ltd., 276 Tamari, Kakegawa, Shizuoka, 436-0011, Japan., Shikano K; Life Science Research Institute, Kumiai Chemical Industry Co., Ltd., 276 Tamari, Kakegawa, Shizuoka, 436-0011, Japan., Yamada K; Safety Research Laboratories, Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-26-1, Muraoka-Higashi, Fujisawa, Kanagawa, 251-8555, Japan., Ono S; Discovery Technology Laboratories, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-Cho, Aoba-Ku, Yokohama, 227-0033, Japan., Hoki M; Research Division, Nihon Nohyaku Co., Ltd., 345, Oyamada-Cho, Kawachinagano-Shi, Osaka, 586-0094, Japan., Ishizuka F; Safety Assessment Department, Nippon Shinyaku Co., Ltd., 14, Nishinosho-Monguchi-Cho, Kisshoin, Minami-Ku, Kyoto, 601-8550, Japan., Hagio S; Biological Research Laboratories, Nissan Chemical Corporation, 1470 Shiraoka, Shiraoka-Shi, Saitama, 349-0294, Japan., Takeshita C; Safety Research Laboratories, Ono Pharmaceutical Co., Ltd, 3-1-1, Sakurai, Shimamoto-Cho, Mishima-Gun, Osaka, 618-8585, Japan., Omori H; Preclinical Basic Research, Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., 3, Okubo, Tsukuba, Ibaraki, 300-2611, Japan., Hashimoto K; Drug Safety Research and Evaluation, Research, Takeda Pharmaceutical Company Limited, Kanagawa, 251-8555, Japan., Chikura S; Teijin Pharma Limited, 4-3-2 Asahigaoka, Hino, Tokyo, 191-8512, Japan., Honma M; Division of Genome Safety Science, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-Ku, Kawasaki, Kanagawa, 210-9501, Japan., Sugiyama KI; Division of Genome Safety Science, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-Ku, Kawasaki, Kanagawa, 210-9501, Japan., Mishima M; Translational Research Division, Chugai Pharmaceutical Co., Ltd., 216-Banchi Totsuka-Cho, Totsuka-Ku, Yokohama, Kanagawa, 244-8602, Japan. mishimamsy@nihs.go.jp.; Division of Genome Safety Science, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-Ku, Kawasaki, Kanagawa, 210-9501, Japan. mishimamsy@nihs.go.jp.

Publikováno v: Genes and environment : the official journal of the Japanese Environmental Mutagen Society [Genes Environ] 2024 Nov 21; Vol. 46 (1), pp. 24. Date of Electronic Publication: 2024 Nov 21.

Lack of in vivo mutagenicity of carbendazim in the liver and glandular stomach of MutaMice.

Autor: Iso T; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan., Suzuki K; Genotoxicology Laboratory, BioSafety Research Center Inc., Shizuoka, Japan., Murata Y; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan., Hirose N; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan., Umano T; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan., Horibata K; Division of Genetics and Mutagenesis, National Institute of Health Sciences, Kanagawa, Japan., Sugiyama KI; Division of Genetics and Mutagenesis, National Institute of Health Sciences, Kanagawa, Japan., Hirose A; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan.; Chemicals Evaluation and Research Institute, Tokyo, Japan., Masumura K; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan., Matsumoto M; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan. mariko@nihs.go.jp.

Publikováno v: Genes and environment : the official journal of the Japanese Environmental Mutagen Society [Genes Environ] 2024 Feb 20; Vol. 46 (1), pp. 7. Date of Electronic Publication: 2024 Feb 20.

Detection of in vivo mutagenicity in rat liver samples using error-corrected sequencing techniques.

Autor: Izawa K; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan. k_izawa@nihs.go.jp., Tsuda M; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan., Suzuki T; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan., Honma M; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan.; Division of General Affairs, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan., Sugiyama KI; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan.

Publikováno v: Genes and environment : the official journal of the Japanese Environmental Mutagen Society [Genes Environ] 2023 Nov 22; Vol. 45 (1), pp. 30. Date of Electronic Publication: 2023 Nov 22.