Local QSAR based on quantum chemistry calculations for the stability of nitrenium ions to reduce false positive outcomes from standard QSAR systems for the mutagenicity of primary aromatic amines.

Autor: Muto S; Translational Research Division, Chugai Pharmaceutical Co., Ltd., 216-Banchi Totsuka-Cho, Totsuka-Ku, Yokohama, Kanagawa, 244-8602, Japan., Furuhama A; Division of Genome Safety Science, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-Ku, Kawasaki, Kanagawa, 210-9501, Japan., Yamamoto M; Non-Clinical Biomedical Science, Applied Research & Operations, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba-Shi, Ibaraki, 305-8585, Japan., Otagiri Y; Human Translational Research Group, EA Pharma Co., Ltd., 2-1-1 Irifune, Chuo-Ku, Tokyo, 104-0042, Japan., Koyama N; Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba-Shi, Ibaraki, 300-2635, Japan., Hitaoka S; Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba-Shi, Ibaraki, 300-2635, Japan., Nagato Y; Toyama Research and Development Center, FUJIFILM Toyama Chemical Co., Ltd., 4-1, Shimookui 2-Chome, Toyama, 930-8508, Japan., Ouchi H; Toxicology Research Lab., Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-13-2 Fukuura, Kanazawa-Ku, Yokohama, Kanagawa, 236-0004, Japan., Ogawa M; Life Science Research Institute, Kumiai Chemical Industry Co., Ltd., 276 Tamari, Kakegawa, Shizuoka, 436-0011, Japan., Shikano K; Life Science Research Institute, Kumiai Chemical Industry Co., Ltd., 276 Tamari, Kakegawa, Shizuoka, 436-0011, Japan., Yamada K; Safety Research Laboratories, Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-26-1, Muraoka-Higashi, Fujisawa, Kanagawa, 251-8555, Japan., Ono S; Discovery Technology Laboratories, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-Cho, Aoba-Ku, Yokohama, 227-0033, Japan., Hoki M; Research Division, Nihon Nohyaku Co., Ltd., 345, Oyamada-Cho, Kawachinagano-Shi, Osaka, 586-0094, Japan., Ishizuka F; Safety Assessment Department, Nippon Shinyaku Co., Ltd., 14, Nishinosho-Monguchi-Cho, Kisshoin, Minami-Ku, Kyoto, 601-8550, Japan., Hagio S; Biological Research Laboratories, Nissan Chemical Corporation, 1470 Shiraoka, Shiraoka-Shi, Saitama, 349-0294, Japan., Takeshita C; Safety Research Laboratories, Ono Pharmaceutical Co., Ltd, 3-1-1, Sakurai, Shimamoto-Cho, Mishima-Gun, Osaka, 618-8585, Japan., Omori H; Preclinical Basic Research, Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., 3, Okubo, Tsukuba, Ibaraki, 300-2611, Japan., Hashimoto K; Drug Safety Research and Evaluation, Research, Takeda Pharmaceutical Company Limited, Kanagawa, 251-8555, Japan., Chikura S; Teijin Pharma Limited, 4-3-2 Asahigaoka, Hino, Tokyo, 191-8512, Japan., Honma M; Division of Genome Safety Science, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-Ku, Kawasaki, Kanagawa, 210-9501, Japan., Sugiyama KI; Division of Genome Safety Science, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-Ku, Kawasaki, Kanagawa, 210-9501, Japan., Mishima M; Translational Research Division, Chugai Pharmaceutical Co., Ltd., 216-Banchi Totsuka-Cho, Totsuka-Ku, Yokohama, Kanagawa, 244-8602, Japan. mishimamsy@nihs.go.jp.; Division of Genome Safety Science, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-Ku, Kawasaki, Kanagawa, 210-9501, Japan. mishimamsy@nihs.go.jp.

Publikováno v: Genes and environment : the official journal of the Japanese Environmental Mutagen Society [Genes Environ] 2024 Nov 21; Vol. 46 (1), pp. 24. Date of Electronic Publication: 2024 Nov 21.

Lack of in vivo mutagenicity of carbendazim in the liver and glandular stomach of MutaMice.

Autor: Iso T; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan., Suzuki K; Genotoxicology Laboratory, BioSafety Research Center Inc., Shizuoka, Japan., Murata Y; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan., Hirose N; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan., Umano T; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan., Horibata K; Division of Genetics and Mutagenesis, National Institute of Health Sciences, Kanagawa, Japan., Sugiyama KI; Division of Genetics and Mutagenesis, National Institute of Health Sciences, Kanagawa, Japan., Hirose A; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan.; Chemicals Evaluation and Research Institute, Tokyo, Japan., Masumura K; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan., Matsumoto M; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan. mariko@nihs.go.jp.

Publikováno v: Genes and environment : the official journal of the Japanese Environmental Mutagen Society [Genes Environ] 2024 Feb 20; Vol. 46 (1), pp. 7. Date of Electronic Publication: 2024 Feb 20.

Detection of in vivo mutagenicity in rat liver samples using error-corrected sequencing techniques.

Autor: Izawa K; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan. k_izawa@nihs.go.jp., Tsuda M; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan., Suzuki T; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan., Honma M; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan.; Division of General Affairs, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan., Sugiyama KI; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan.

Publikováno v: Genes and environment : the official journal of the Japanese Environmental Mutagen Society [Genes Environ] 2023 Nov 22; Vol. 45 (1), pp. 30. Date of Electronic Publication: 2023 Nov 22.

Evaluation of QSAR models for predicting mutagenicity: outcome of the Second Ames/QSAR international challenge project.

Autor: Furuhama A; Division of Genetics and Mutagenesis (DGM), National Institute of Health Sciences (NIHS), Kawasaki, Japan., Kitazawa A; Division of Genetics and Mutagenesis (DGM), National Institute of Health Sciences (NIHS), Kawasaki, Japan., Yao J; Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials (Chinese Academy of Sciences), Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (SIOC, CAS), Shanghai, China., Matos Dos Santos CE; Department of Computational Toxicology and In Silico Innovations, Altox Ltd, São Paulo-SP, Brazil., Rathman J; MN-AM, Nuremberg, Germany/Columbus, OH, USA., Yang C; MN-AM, Nuremberg, Germany/Columbus, OH, USA., Ribeiro JV; MN-AM, Nuremberg, Germany/Columbus, OH, USA., Cross K; In Silico Department, Instem, Conshohocken, PA, USA., Myatt G; In Silico Department, Instem, Conshohocken, PA, USA., Raitano G; Laboratory of Environmental Toxicology and Chemistry, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS (IRFMN), Milano, Italy., Benfenati E; Laboratory of Environmental Toxicology and Chemistry, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS (IRFMN), Milano, Italy., Jeliazkova N; IdeaConsult Ltd, Sofia, Bulgaria., Saiakhov R; MultiCASE Inc, Mayfield Height, OH, USA., Chakravarti S; MultiCASE Inc, Mayfield Height, OH, USA., Foster RS; Lhasa Ltd, Leeds, UK., Bossa C; Environment and Health Department, Istituto Superiore di Sanità (ISS), Rome, Italy., Battistelli CL; Environment and Health Department, Istituto Superiore di Sanità (ISS), Rome, Italy., Benigni R; Environment and Health Department, Istituto Superiore di Sanità (ISS), Rome, Italy.; Alpha-PreTox, Rome, Italy., Sawada T; Faculty of Regional Studies, Gifu University, Gifu, Japan.; xenoBiotic Inc, Gifu, Japan., Wasada H; Faculty of Regional Studies, Gifu University, Gifu, Japan., Hashimoto T; Faculty of Regional Studies, Gifu University, Gifu, Japan., Wu M; Massachusetts Institute of Technology, Cambridge, MA, USA., Barzilay R; Massachusetts Institute of Technology, Cambridge, MA, USA., Daga PR; Simulations Plus, Lancaster, CA, USA., Clark RD; Simulations Plus, Lancaster, CA, USA., Mestres J; Chemotargets, Barcelona, Spain., Montero A; Chemotargets, Barcelona, Spain., Gregori-Puigjané E; Chemotargets, Barcelona, Spain., Petkov P; LMC - Bourgas University, Bourgas, Bulgaria., Ivanova H; LMC - Bourgas University, Bourgas, Bulgaria., Mekenyan O; LMC - Bourgas University, Bourgas, Bulgaria., Matthews S; Computational Pharmacology & Toxicology Laboratory, Discipline of Pharmacology, School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia., Guan D; Computational Pharmacology & Toxicology Laboratory, Discipline of Pharmacology, School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia., Spicer J; Computational Pharmacology & Toxicology Laboratory, Discipline of Pharmacology, School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia., Lui R; Computational Pharmacology & Toxicology Laboratory, Discipline of Pharmacology, School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia., Uesawa Y; Department of Medical Molecular Informatics, Meiji Pharmaceutical University, Tokyo, Japan., Kurosaki K; Department of Medical Molecular Informatics, Meiji Pharmaceutical University, Tokyo, Japan., Matsuzaka Y; Department of Medical Molecular Informatics, Meiji Pharmaceutical University, Tokyo, Japan., Sasaki S; Department of Medical Molecular Informatics, Meiji Pharmaceutical University, Tokyo, Japan., Cronin MTD; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK., Belfield SJ; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK., Firman JW; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK., Spînu N; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK., Qiu M; Evergreen AI, Inc, Toronto, Canada., Keca JM; Evergreen AI, Inc, Toronto, Canada., Gini G; Department of Electronics, Information and Bioengineering (DEIB), Politecnico di Milano, Milano, Italy., Li T; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration (NCTR/FDA), Jefferson, AR, USA., Tong W; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration (NCTR/FDA), Jefferson, AR, USA., Hong H; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration (NCTR/FDA), Jefferson, AR, USA., Liu Z; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration (NCTR/FDA), Jefferson, AR, USA.; Integrative Toxicology, Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT, USA., Igarashi Y; Artificial Intelligence Center for Health and Biomedical Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka, Japan., Yamada H; Artificial Intelligence Center for Health and Biomedical Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka, Japan., Sugiyama KI; Division of Genetics and Mutagenesis (DGM), National Institute of Health Sciences (NIHS), Kawasaki, Japan., Honma M; Division of Genetics and Mutagenesis (DGM), National Institute of Health Sciences (NIHS), Kawasaki, Japan.

Publikováno v: SAR and QSAR in environmental research [SAR QSAR Environ Res] 2023 Oct-Dec; Vol. 34 (12), pp. 983-1001. Date of Electronic Publication: 2023 Dec 04.

In vivo mutagenicity assessment of styrene in MutaMouse liver and lung.

Autor: Murata Y; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan., Natsume M; Genotoxicology Laboratory, BioSafety Research Center Inc, Shizuoka, Japan., Iso T; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan., Shigeta Y; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan., Hirose N; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan., Umano T; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan., Horibata K; Division of Genetics and Mutagenesis, National Institute of Health Sciences, Kanagawa, Japan., Sugiyama KI; Division of Genetics and Mutagenesis, National Institute of Health Sciences, Kanagawa, Japan., Masumura K; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan., Hirose A; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan.; Chemicals Evaluation and Research Institute, Tokyo, Japan., Matsumoto M; Division of Risk Assessment, National Institute of Health Sciences, Kanagawa, Japan. mariko@nihs.go.jp.

Publikováno v: Genes and environment : the official journal of the Japanese Environmental Mutagen Society [Genes Environ] 2023 Apr 11; Vol. 45 (1), pp. 12. Date of Electronic Publication: 2023 Apr 11.