Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Sugirthan Sivalingam"'
Autor:
Felix Wiegand, Bianca Stöcker, Famke Bäuerle, Susanne Motameny, Andreas Buness, Alexander J. Probst, Fabian Brand, Axel Schmidt, Tyll Stöcker, Sugirthan Sivalingam, Andreas Petzold, Marc Sturm, Janine Altmueller, Johannes Köster, Kerstin Becker, Leon Brandhoff, Anna Ossowski, Christian Mertes, Avirup Guha Neogi, Gisela Gabernet, Nicholas H. Smith, Friederike Hanssen
Publikováno v:
F1000Research, Vol 12 (2024)
We present the results of the human genomic small variant calling benchmarking initiative of the German Research Foundation (DFG) funded Next Generation Sequencing Competence Network (NGS-CN) and the German Human Genome-Phenome Archive (GHGA). In thi
Externí odkaz:
https://doaj.org/article/117f3609dd9e44c58c2a7e52d9ff948e
Autor:
Sabrina Katrin Henne, Rana Aldisi, Sugirthan Sivalingam, Lara Maleen Hochfeld, Oleg Borisov, Peter Michael Krawitz, Carlo Maj, Markus Maria Nöthen, Stefanie Heilmann-Heimbach
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Male-pattern hair loss (MPHL) is common and highly heritable. While genome-wide association studies (GWAS) have generated insights into the contribution of common variants to MPHL etiology, the relevance of rare variants remains unclear. To
Externí odkaz:
https://doaj.org/article/a171b6aa33ba46fa9e50d5a3280cd103
Autor:
Rana Aldisi, Emadeldin Hassanin, Sugirthan Sivalingam, Andreas Buness, Hannah Klinkhammer, Andreas Mayr, Holger Fröhlich, Peter Krawitz, Carlo Maj
Publikováno v:
BMC Genomic Data, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Background A relevant part of the genetic architecture of complex traits is still unknown; despite the discovery of many disease-associated common variants. Polygenic risk score (PRS) models are based on the evaluation of the additive effect
Externí odkaz:
https://doaj.org/article/54759c07922f4167a261203d0f68ded4
Autor:
Nina Ishorst, Leonie Henschel, Frederic Thieme, Dmitriy Drichel, Sugirthan Sivalingam, Sarah L. Mehrem, Ariane C. Fechtner, Julia Fazaal, Julia Welzenbach, André Heimbach, Carlo Maj, Oleg Borisov, Jonas Hausen, Ruth Raff, Alexander Hoischen, Michael Dixon, Alvaro Rada‐Iglesias, Michaela Bartusel, Augusto Rojas‐Martinez, Khalid Aldhorae, Bert Braumann, Teresa Kruse, Christian Kirschneck, Gerrit Spanier, Heiko Reutter, Stefanie Nowak, Lina Gölz, Michael Knapp, Andreas Buness, Peter Krawitz, Markus M. Nöthen, Michael Nothnagel, Tim Becker, Kerstin U. Ludwig, Elisabeth Mangold
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 11, Iss 3, Pp n/a-n/a (2023)
Abstract Background Nonsyndromic cleft lip with/without cleft palate (nsCL/P) is a congenital malformation of multifactorial etiology. Research has identified >40 genome‐wide significant risk loci, which explain less than 40% of nsCL/P heritability
Externí odkaz:
https://doaj.org/article/205be1f83d914d678ac7257527a61a58
Autor:
Marek Korencak, Sugirthan Sivalingam, Anshupa Sahu, Dietmar Dressen, Axel Schmidt, Fabian Brand, Peter Krawitz, Libor Hart, Anna Maria Eis-Hübinger, Andreas Buness, Hendrik Streeck
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2292-2296 (2022)
The first major COVID-19 outbreak in Germany occurred in Heinsberg in February 2020 with 388 officially reported cases. Unexpectedly, the first outbreak happened in a small town with little to no travelers. We used phylogenetic analyses to investigat
Externí odkaz:
https://doaj.org/article/afa7b5515a474a39b4f66c629aaa38bd
Autor:
Axel Schmidt, Sophia Peters, Alexej Knaus, Hemmen Sabir, Frauke Hamsen, Carlo Maj, Julia Fazaal, Sugirthan Sivalingam, Oleksandr Savchenko, Aakash Mantri, Dirk Holzinger, Ulrich Neudorf, Andreas Müller, Kerstin U. Ludwig, Peter M. Krawitz, Hartmut Engels, Markus M. Nöthen, Soyhan Bagci
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-5 (2021)
Abstract Among children, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are typically mild. Here, we describe the case of a 3.5-year-old girl with an unusually severe presentation of coronavirus disease (COVID-19). The child
Externí odkaz:
https://doaj.org/article/4dce3d58fba2448da97475e6d1005e93
Autor:
Axel Krug, Markus Wöhr, Dominik Seffer, Henrike Rippberger, A. Özge Sungur, Bruno Dietsche, Frederike Stein, Sugirthan Sivalingam, Andreas J. Forstner, Stephanie H. Witt, Helene Dukal, Fabian Streit, Anna Maaser, Stefanie Heilmann-Heimbach, Till F. M. Andlauer, Stefan Herms, Per Hoffmann, Marcella Rietschel, Markus M. Nöthen, Martin Lackinger, Gerhard Schratt, Michael Koch, Rainer K. W. Schwarting, Tilo Kircher
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-19 (2020)
Abstract Advanced paternal age (APA) is a risk factor for several neurodevelopmental disorders, including autism and schizophrenia. The potential mechanisms conferring this risk are poorly understood. Here, we show that the personality traits schizot
Externí odkaz:
https://doaj.org/article/06f7773622724f6e8c4366eee4a1e2fc
Autor:
Ashley L. Comes, Darina Czamara, Kristina Adorjan, Heike Anderson-Schmidt, Till F. M. Andlauer, Monika Budde, Katrin Gade, Maria Hake, Janos L. Kalman, Sergi Papiol, Daniela Reich-Erkelenz, Farah Klöhn-Saghatolislam, Sabrina K. Schaupp, Eva C. Schulte, Fanny Senner, Georg Juckel, Max Schmauß, Jörg Zimmermann, Jens Reimer, Eva Reininghaus, Ion-George Anghelescu, Carsten Konrad, Andreas Thiel, Christian Figge, Martin von Hagen, Manfred Koller, Detlef E. Dietrich, Sebastian Stierl, Harald Scherk, Stephanie H. Witt, Sugirthan Sivalingam, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Nöthen, Jens Wiltfang, Peter Falkai, Thomas G. Schulze, Urs Heilbronner
Publikováno v:
International Journal of Bipolar Disorders, Vol 8, Iss 1, Pp 1-12 (2020)
Abstract Background Stressful life events influence the course of affective disorders, however, the mechanisms by which they bring about phenotypic change are not entirely known. Methods We explored the role of DNA methylation in response to recent s
Externí odkaz:
https://doaj.org/article/d9a20649518a4c5f8f2c241edc22b781
Autor:
Claudia Perne, Sophia Peters, Maria Cartolano, Sukanya Horpaopan, Christina Grimm, Janine Altmüller, Anna K Sommer, Axel M Hillmer, Holger Thiele, Margarete Odenthal, Gabriela Möslein, Ronja Adam, Sugirthan Sivalingam, Jutta Kirfel, Michal R Schweiger, Martin Peifer, Isabel Spier, Stefan Aretz
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0259185 (2021)
The spectrum of somatic genetic variation in colorectal adenomas caused by biallelic pathogenic germline variants in the MSH3 gene, was comprehensively analysed to characterise mutational signatures and identify potential driver genes and pathways of
Externí odkaz:
https://doaj.org/article/6bc898b6a61f4b74a29ec7af0aec5145
Autor:
Christina K. Weisheit, Alexandra Klüners, Lennart Wild, Alexandra Casalter, Stefanie Heilmann-Heimbach, Sugirthan Sivalingam, Jan L. Kleiner, Stefan F. Ehrentraut, Andreas Hoeft, Stilla Frede, Heidi Ehrentraut
Publikováno v:
Mediators of Inflammation, Vol 2020 (2020)
Sepsis is associated with a strong inflammatory reaction triggering a complex and prolonged immune response. Septic patients have been shown to develop sustained immunosuppression due to a reduced responsiveness of leukocytes to pathogens. Changes in
Externí odkaz:
https://doaj.org/article/80c29043c066440e8e0f77d72f338990