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Akademický článek

Controlled aggregative assembly to form self-organizing macroscopic human intestine from induced pluripotent stem cells.

Autor: Takahashi J; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Sugihara HY; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Kato S; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Kawasaki S; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Nagata S; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Okamoto R; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Mizutani T; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. Electronic address: tmizutani.gast@tmd.ac.jp.

Publikováno v: Cell reports methods [Cell Rep Methods] 2024 Dec 16; Vol. 4 (12), pp. 100930. Date of Electronic Publication: 2024 Dec 10.

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Akademický článek

Protocol to generate large human intestinal organoids using a rotating bioreactor.

Autor: Takahashi J; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. Electronic address: jtakahashi.gast@tmd.ac.jp., Sugihara HY; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Kato S; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Nagata S; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Okamoto R; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Mizutani T; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. Electronic address: tmizutani.gast@tmd.ac.jp.

Publikováno v: STAR protocols [STAR Protoc] 2023 Sep 15; Vol. 4 (3), pp. 102374. Date of Electronic Publication: 2023 Jun 22.

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Akademický článek

Suspension culture in a rotating bioreactor for efficient generation of human intestinal organoids.

Autor: Takahashi J; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Mizutani T; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Sugihara HY; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Nagata S; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Kato S; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Hiraguri Y; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Takeoka S; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Tsuchiya M; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Kuno R; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Kakinuma S; Department of Clinical and Diagnostic Laboratory Science, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Watanabe M; Advanced Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan., Okamoto R; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

Publikováno v: Cell reports methods [Cell Rep Methods] 2022 Nov 15; Vol. 2 (11), pp. 100337. Date of Electronic Publication: 2022 Nov 15 (Print Publication: 2022).

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Akademický článek

Functional analysis of isoflavones using patient-derived human colonic organoids.

Autor: Tsuchiya M; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Ito G; Advanced Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Hama M; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Nagata S; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Kawamoto A; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Suzuki K; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Shimizu H; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Anzai S; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Takahashi J; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Kuno R; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Takeoka S; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Hiraguri Y; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Sugihara HY; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Mizutani T; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Yui S; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan; Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Oshima S; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Tsuchiya K; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Watanabe M; Advanced Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Okamoto R; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan; Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. Electronic address: rokamoto.gast@tmd.ac.jp.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jan 20; Vol. 542, pp. 40-47. Date of Electronic Publication: 2021 Jan 20.

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Akademický článek

Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients.

Autor: Kuno R; Department of Gastroenterology and Hepatology, Japan., Ito G; Advanced Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Kawamoto A; Department of Gastroenterology and Hepatology, Japan., Hiraguri Y; Department of Gastroenterology and Hepatology, Japan., Sugihara HY; Department of Gastroenterology and Hepatology, Japan., Takeoka S; Department of Gastroenterology and Hepatology, Japan., Nagata S; Department of Gastroenterology and Hepatology, Japan., Takahashi J; Department of Gastroenterology and Hepatology, Japan., Tsuchiya M; Department of Gastroenterology and Hepatology, Japan., Anzai S; Department of Gastroenterology and Hepatology, Japan., Mizutani T; Department of Gastroenterology and Hepatology, Japan., Shimizu H; Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Yui S; Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Oshima S; Department of Gastroenterology and Hepatology, Japan., Tsuchiya K; Department of Gastroenterology and Hepatology, Japan., Watanabe M; Advanced Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Okamoto R; Department of Gastroenterology and Hepatology, Japan.; Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

Publikováno v: Biochemistry and biophysics reports [Biochem Biophys Rep] 2021 Jan 11; Vol. 25, pp. 100906. Date of Electronic Publication: 2021 Jan 11 (Print Publication: 2021).

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Akademický článek

TGF-β promotes fetal gene expression and cell migration velocity in a wound repair model of untransformed intestinal epithelial cells.

Autor: Anzai S; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8519, Japan., Kawamoto A; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8519, Japan., Nagata S; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8519, Japan., Takahashi J; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8519, Japan., Kawai M; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8519, Japan., Kuno R; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8519, Japan., Kobayashi S; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8519, Japan., Watanabe S; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8519, Japan., Suzuki K; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8519, Japan., Shimizu H; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8519, Japan., Hiraguri Y; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8519, Japan., Takeoka S; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8519, Japan., Sugihara HY; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8519, Japan., Yui S; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8519, Japan; Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8519, Japan., Oshima S; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8519, Japan., Watanabe M; Advanced Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8519, Japan., Okamoto R; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8519, Japan; Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8519, Japan. Electronic address: rokamoto.gast@tmd.ac.jp.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Apr 09; Vol. 524 (3), pp. 533-541. Date of Electronic Publication: 2020 Feb 01.

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Akademický článek

Organoid-based regenerative medicine for inflammatory bowel disease.

Autor: Okamoto R; Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Shimizu H; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Suzuki K; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Kawamoto A; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Takahashi J; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Kawai M; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Nagata S; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Hiraguri Y; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Takeoka S; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Sugihara HY; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Yui S; Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan., Watanabe M; Institute of Advanced Study, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

Publikováno v: Regenerative therapy [Regen Ther] 2020 Jan 13; Vol. 13, pp. 1-6. Date of Electronic Publication: 2020 Jan 13 (Print Publication: 2020).

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