Integrated Analyses of Genome-Wide DNA Occupancy and Expression Profiling Identify Key Genes and Pathways Involved in Cellular Transformation by a Marek's Disease Virus Oncoprotein, Meq

Autor: Hsing Jien Kung, Titus C. Brown, Hans H. Cheng, Sugalesini Subramaniam, Likit Preeyanon, John Johnston

Publikováno v: Journal of Virology. 87:9016-9029

Marek's disease (MD) is an economically significant disease in chickens that is caused by the highly oncogenic Marek's disease virus (MDV). A major unanswered question is the mechanism of MDV-induced tumor formation. Meq, a bZIP transcription factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddd05545738c5339381bc2ac99f7f79
https://doi.org/10.1128/jvi.01163-13

Nuclear Factor kappa B is central to Marek's Disease herpesvirus induced neoplastic transformation of CD30 expressing lymphocytes in-vivo

Autor: Joram Buza, Dusan Kunec, Hans H. Cheng, Hsin-I Chiang, Shane C. Burgess, Ken Pendarvis, Huaijun Zhou, Sugalesini Subramaniam, Shyamesh Kumar

Publikováno v: Kumar, Shyamesh; Kunec, Dusan; Buza, Joram J; Chiang, Hsin-I; Zhou, Huaijun; Subramaniam, Sugalesini; et al.(2012). Nuclear Factor kappa B is central to Marek's Disease herpesvirus induced neoplastic transformation of CD30 expressing lymphocytes in-vivo. BMC Systems Biology, 6(1), 123. doi: http://dx.doi.org/10.1186/1752-0509-6-123. Retrieved from: http://www.escholarship.org/uc/item/848011v1
BMC Systems Biology, Vol 6, Iss 1, p 123 (2012)
BMC Systems Biology

Background Marek’s Disease (MD) is a hyperproliferative, lymphomatous, neoplastic disease of chickens caused by the oncogenic Gallid herpesvirus type 2 (GaHV-2; MDV). Like several human lymphomas the neoplastic MD lymphoma cells overexpress the CD3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6956725be5e45a786c0e34e6c9d4d88
http://www.escholarship.org/uc/item/848011v1