Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Sufi Mary Thomas"'
Autor:
Levi Arnold, Juan Pineda Gomez, Michael Barry, Marrion Yap, Laura Jackson, Thuc Ly, David Standing, Subhash B. Padhye, Bernhard Biersack, Shrikant Anant, Sufi Mary Thomas
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 5, Pp 1104-1121 (2023)
Aim: Head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer worldwide with a survival rate below fifty percent. Addressing meager therapeutic options, a series of small molecule inhibitors were screened for antitumor efficacy
Externí odkaz:
https://doaj.org/article/ef3a66bf9d4e4aa092912605d8161203
Autor:
David Standing, Emma Feess, Satvik Kodiyalam, Michael Kuehn, Zachary Hamel, Jaimie Johnson, Sufi Mary Thomas, Shrikant Anant
Publikováno v:
Cancers, Vol 15, Iss 9, p 2485 (2023)
Ovarian cancer (OvCa) is a deadly gynecologic malignancy that presents many clinical challenges due to late-stage diagnoses and the development of acquired resistance to standard-of-care treatment protocols. There is an increasing body of evidence su
Externí odkaz:
https://doaj.org/article/71b07cde35e64c9dae987cea652e3807
Publikováno v:
Cancers, Vol 15, Iss 6, p 1899 (2023)
Cancer cells rely on the tumor microenvironment (TME), a composite of non-malignant cells, and extracellular matrix (ECM), for survival, growth, and metastasis. The ECM contributes to the biomechanical properties of the surrounding tissue, in additio
Externí odkaz:
https://doaj.org/article/98409293ef5e4ca7bdbd241c7efc045b
Publikováno v:
Microorganisms, Vol 11, Iss 2, p 318 (2023)
The oral microbiome is an emerging field that has been a topic of discussion since the development of next generation sequencing and the implementation of the human microbiome project. This article reviews the current literature surrounding the oral
Externí odkaz:
https://doaj.org/article/3f063d24c8df448c8775b3d59f32db6b
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 4, Iss 5, Pp 508-512 (2019)
Human papilloma virus (HPV) has been implicated in the development of oropharyngeal squamous cell carcinoma (OPSCC) and is directly attributed to its increasing incidence. The immune microenvironment surrounding HPV‐associated OPSCC tumors is compl
Externí odkaz:
https://doaj.org/article/9749fcb8162a4d6281360d4beac9b4ac
Autor:
Kaleigh N. Doke, MD, Laine Bowman, MA, OTR, Yelizaveta Shnayder, MD, Xinglei Shen, MD, Mindi TenNapel, PhD, Sufi Mary Thomas, PhD, Prakash Neupane, MD, Hung-Wen Yeh, PhD, Chris E. Lominska, MD
Publikováno v:
Advances in Radiation Oncology, Vol 3, Iss 3, Pp 366-371 (2018)
Purpose: Head and neck surgery and radiation cause tissue fibrosis that leads to functional limitations and lymphedema. The objective of this study was to determine whether lymphedema therapy after surgery and radiation for head and neck cancer decre
Externí odkaz:
https://doaj.org/article/7f256fe317094cc58309faaf1eda01df
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Malignant tumors contain heterogeneous populations of cells in various states of proliferation and differentiation. The presence of cancer stem or initiating cells is a well-established concept wherein quiescent and poorly differentiated cells within
Externí odkaz:
https://doaj.org/article/7a56ac2f536e4b8ca7859ba5cb0eb3bc
Publikováno v:
Cancers, Vol 9, Iss 12, p 169 (2017)
Head and neck squamous cell carcinoma (HNSCC) is a highly morbid disease. Recent developments including Food and Drug Administration (FDA) approved molecular targeted agent’s pembrolizumab and cetuximab show promise but did not improve the five-yea
Externí odkaz:
https://doaj.org/article/0307ba5aa91c448684496560f1f6828e
Autor:
Sufi Mary Thomas, Jennifer Rubin Grandis, Abbey L. Wentzel, William E. Gooding, Vivian Wai Yan Lui, Jill M. Siegfried
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 4, Pp 426-431 (2005)
Gastrin-releasing peptide receptor (GRPR) and the epidermal growth factor receptor (EGFR) are expressed in several cancers including non-small cell lung carcinoma (NSCLC). Here we demonstrate the activation of EGFR by the GRPR ligand, gastrin-releasi
Externí odkaz:
https://doaj.org/article/4209b4060d2d42699e1df238500e320b
Autor:
David Standing, Levi Arnold, Prasad Dandawate, Brendan Ottemann, Vusala Snyder, Sivapriya Ponnurangam, Afreen Sayed, Dharmalingam Subramaniam, Pugazhendhi Srinivasan, Sonali Choudhury, Jacob New, Deep Kwatra, Prabhu Ramamoorthy, Badal C. Roy, Melissa Shadoin, Raed Al‐Rajabi, Maura O'Neil, Sumedha Gunewardena, John Ashcraft, Shahid Umar, Scott J. Weir, Ossama Tawfik, Subhash B. Padhye, Bernhard Biersack, Shrikant Anant, Sufi Mary Thomas
Publikováno v:
Molecular Carcinogenesis. 62:145-159
Doublecortin like kinase 1 (DCLK1) plays a crucial role in several cancers including colon and pancreatic adenocarcinomas. However, its role in squamous cell carcinoma (SCC) remains unknown. To this end, we examined DCLK1 expression in head and neck