Zobrazeno 1 - 10
of 293
pro vyhledávání: '"Suet Yi, Leung"'
Autor:
Rongting Huang, Xianjie Huang, Yin Tong, Helen Y. N. Yan, Suet Yi Leung, Oliver Stegle, Yuanhua Huang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Somatic copy number alterations (CNAs) are major mutations that contribute to the development and progression of various cancers. Despite a few computational methods proposed to detect CNAs from single-cell transcriptomic data, the technical
Externí odkaz:
https://doaj.org/article/f990e18af0274fb49383eb97aa4b5d7c
Autor:
Tin-Lok Wong, Jia-Jian Loh, Shixun Lu, Helen H. N. Yan, Hoi Cheong Siu, Ren Xi, Dessy Chan, Max J. F. Kam, Lei Zhou, Man Tong, John A. Copland, Leilei Chen, Jing-Ping Yun, Suet Yi Leung, Stephanie Ma
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Targetable drivers governing 5-fluorouracil and cisplatin (5FU + CDDP) resistance remain elusive due to the paucity of physiologically and therapeutically relevant models. Here, we establish 5FU + CDDP resistant intestinal subtype GC patient
Externí odkaz:
https://doaj.org/article/0ad6ea25978a47d9b5edba84b643c792
Autor:
Chelsea C.W. Lo, Carman Nga-Man Cheung, Clive H.Y. Wong, Gordon Qian, Preeti Dinesh Virwani, Yick Hin Chow, Yiu-Hei Tse, Matthew S.S. Hsu, Tommy K.K.T.S. Pijarnvanit, Jia-Wen Xian, Shirley Sau-Wing Lam, Crystal P.I. Lee, Roxanna K.C. Liu, Suet Yi Leung, Ivan Fan- Ngai Hung, Joshua Wing Kei Ho, Tatia M.C. Lee, Kui Kai Lau
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100322- (2024)
Introduction: Whilst gut microbiome (GM) dysregulation and glymphatic dysfunction have been identified as emerging risk factors of dementia in symptomatic individuals, it is unknown whether GM is associated with the glymphatic system, especially in t
Externí odkaz:
https://doaj.org/article/213e1e4096d24f6aba2c7376e72a6424
Autor:
Lingling Wang, Haobin Yao, Daniel C. Morgan, Kam Shing Lau, Suet Yi Leung, Joshua W. K. Ho, Wai K. Leung
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Transient gut microbiota alterations have been reported after antibiotic therapy for Helicobacter pylori. However, alteration in the gut virome after H. pylori eradication remains uncertain. Here, we apply metagenomic sequencing to fecal sam
Externí odkaz:
https://doaj.org/article/7abc0c40bf424e4c8be56f3b718dc6b0
Autor:
Bernard C. H. Lee, Philip S. Robinson, Tim H. H. Coorens, Helen H. N. Yan, Sigurgeir Olafsson, Henry Lee-Six, Mathijs A. Sanders, Hoi Cheong Siu, James Hewinson, Sarah S. K. Yue, Wai Yin Tsui, Annie S. Y. Chan, Anthony K. W. Chan, Siu Lun Ho, Peter J. Campbell, Inigo Martincorena, Simon J. A. Buczacki, Siu Tsan Yuen, Suet Yi Leung, Michael R. Stratton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
It is unclear whether somatic mutation rates are elevated in Lynch Syndrome (LS), which is the most common cause of hereditary colorectal cancer. Here, the authors use whole-genome sequencing and organoid cultures to show that normal tissues in LS pa
Externí odkaz:
https://doaj.org/article/9ffe8e161f6f47b6ae292571819e0a78
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 19, Iss , Pp 1423-1433 (2020)
MicroRNAs (miRNAs) have been shown to be closely related to cancer progression. Traditional methods for discovering cancer-related miRNAs mostly require significant marginal differential expression, but some cancer-related miRNAs may be non-different
Externí odkaz:
https://doaj.org/article/b97fde870de940f78ed8b2089714c2f5
Autor:
Preeti Dinesh Virwani, Gordon Qian, Matthew S.S. Hsu, Tommy K.K.T.S. Pijarnvanit, Carman Nga-Man Cheung, Yick Hin Chow, Lok Kan Tang, Yiu-Hei Tse, Jia-Wen Xian, Shirley Sau-Wing Lam, Crystal P.I. Lee, Chelsea C.W. Lo, Roxanna K.C. Liu, Tsi Lok Ho, Bak Yue Chow, Kin Sum Leung, Hing Wai Tsang, Emily K.K. Lo, Keith T.S. Tung, Sookja Kim Chung, Man-Fung Yuen, Suet Yi Leung, Patrick Ip, Ivan Fan-Ngai Hung, Jimmy Chun Yu Louie, Hani El-Nezami, Joshua Wing Kei Ho, Kui Kai Lau
Publikováno v:
Hypertension. 80:1331-1342
Background: Sex differences in the pathogenesis of hypertension exist. While gut microbiota (GM) has been associated with hypertension, it is unclear whether there are sex-linked differences in the association between GM and hypertension. Methods: We
Autor:
Peng Zhou, Becky K.C. Chan, Yuk Kei Wan, Chaya T.L. Yuen, Gigi C.G. Choi, Xinran Li, Cindy S.W. Tong, Sophia S.W. Zhong, Jieran Sun, Yufan Bao, Silvia Y.L. Mak, Maggie Z.Y. Chow, Jien Vei Khaw, Suet Yi Leung, Zongli Zheng, Lydia W.T. Cheung, Kaeling Tan, Koon Ho Wong, H.Y. Edwin Chan, Alan S.L. Wong
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 108020- (2020)
Summary: We present a CRISPR-based multi-gene knockout screening system and toolkits for extensible assembly of barcoded high-order combinatorial guide RNA libraries en masse. We apply this system for systematically identifying not only pairwise but
Externí odkaz:
https://doaj.org/article/24174da9c12342599b0cf0c61b4eb1cd
Autor:
Yin Tong, Jianlong Sun, Chi Fat Wong, Qingzheng Kang, Beibei Ru, Ching Ngar Wong, April Sheila Chan, Suet Yi Leung, Jiangwen Zhang
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-17 (2018)
Abstract Aberrant promoter methylation is a common mechanism for tumor suppressor inactivation in cancer. We develop a set of tools to identify genome-wide DNA methylation in distal regions with causal effect on tumorigenesis called MICMIC. Many pred
Externí odkaz:
https://doaj.org/article/8a6dcb37f9db48b38bc01aec0c1c0785
Autor:
Rongting Huang, Xianjie Huang, Yin Tong, Helen Y.N. Yan, Suet Yi Leung, Oliver Stegle, Yuanhua Huang
Somatic copy number variations (CNVs) are major mutations in various cancers for their development and clonal progression. A few computational methods have been proposed to detect CNVs from single-cell transcriptomic data. Still, the technical sparsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b624ecddc27886eb63dd09c7156a0084
https://doi.org/10.1101/2023.04.03.535352
https://doi.org/10.1101/2023.04.03.535352