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Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.

Autor: Fuchs S; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany. steffen.fuchs@charite.de.; The German Cancer Consortium (DKTK), Partner Site Berlin, 10117, Berlin, Germany. steffen.fuchs@charite.de.; The German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. steffen.fuchs@charite.de.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 10178, Berlin, Germany. steffen.fuchs@charite.de.; CRCT, Inserm, CNRS, Université Toulouse III-Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, Université de Toulouse, 31037, Toulouse, France. steffen.fuchs@charite.de.; Laboratoire d'Excellence Toulouse Cancer-TOUCAN, 31037, Toulouse, France. steffen.fuchs@charite.de., Danßmann C; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany., Klironomos F; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany., Winkler A; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany., Fallmann J; Bioinformatics Group, Department of Computer Science, and Interdisciplinary Center for Bioinformatics, University of Leipzig, 04107, Leipzig, Germany., Kruetzfeldt LM; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany., Szymansky A; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany., Naderi J; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, 14195, Berlin, Germany., Bernhart SH; Bioinformatics Group, Department of Computer Science, and Interdisciplinary Center for Bioinformatics, University of Leipzig, 04107, Leipzig, Germany., Grunewald L; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.; The German Cancer Consortium (DKTK), Partner Site Berlin, 10117, Berlin, Germany.; The German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany., Helmsauer K; Experimental and Clinical Research Center (ECRC) of the Charité and Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, 13125, Berlin, Germany., Rodriguez-Fos E; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.; Experimental and Clinical Research Center (ECRC) of the Charité and Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, 13125, Berlin, Germany., Kirchner M; Core Unit Proteomics, Berlin Institute of Health at Charité - Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine (MDC), 13125, Berlin, Germany., Mertins P; Core Unit Proteomics, Berlin Institute of Health at Charité - Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine (MDC), 13125, Berlin, Germany., Astrahantseff K; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany., Suenkel C; Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Hannoversche Straße 28, 10115, Berlin, Germany.; Lonza Drug Product Services, 4057, Basel, Switzerland., Toedling J; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.; The German Cancer Consortium (DKTK), Partner Site Berlin, 10117, Berlin, Germany.; The German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany., Meggetto F; CRCT, Inserm, CNRS, Université Toulouse III-Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, Université de Toulouse, 31037, Toulouse, France.; Laboratoire d'Excellence Toulouse Cancer-TOUCAN, 31037, Toulouse, France., Remke M; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Düsseldorf, Medical Faculty, and University Hospital Düsseldorf, 40225, Düsseldorf, Germany.; The German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, 40225, Düsseldorf, Germany.; Institute of Neuropathology, Heinrich Heine University Düsseldorf, Medical Faculty, and University Hospital Düsseldorf, 40225, Düsseldorf, Germany., Stadler PF; Bioinformatics Group, Department of Computer Science, and Interdisciplinary Center for Bioinformatics, University of Leipzig, 04107, Leipzig, Germany., Hundsdoerfer P; Department of Pediatric Oncology, Helios Klinikum Berlin-Buch, 13125, Berlin, Germany., Deubzer HE; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.; The German Cancer Consortium (DKTK), Partner Site Berlin, 10117, Berlin, Germany.; The German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 10178, Berlin, Germany.; Experimental and Clinical Research Center (ECRC) of the Charité and Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, 13125, Berlin, Germany., Künkele A; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.; The German Cancer Consortium (DKTK), Partner Site Berlin, 10117, Berlin, Germany.; The German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany., Lang P; Department I - General Pediatrics, Hematology/Oncology, University Children's Hospital, Eberhard Karls University Tuebingen, 72076, Tuebingen, Germany., Fuchs J; Department of Pediatric Surgery and Pediatric Urology, University Children's Hospital, Eberhard Karls University Tuebingen, 72076, Tuebingen, Germany., Henssen AG; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.; The German Cancer Consortium (DKTK), Partner Site Berlin, 10117, Berlin, Germany.; The German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Experimental and Clinical Research Center (ECRC) of the Charité and Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, 13125, Berlin, Germany., Eggert A; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.; The German Cancer Consortium (DKTK), Partner Site Berlin, 10117, Berlin, Germany.; The German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 10178, Berlin, Germany., Rajewsky N; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.; Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Hannoversche Straße 28, 10115, Berlin, Germany., Hertwig F; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.; The German Cancer Consortium (DKTK), Partner Site Berlin, 10117, Berlin, Germany.; The German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany., Schulte JH; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany. johannes.schulte@med.uni-tuebingen.de.; The German Cancer Consortium (DKTK), Partner Site Berlin, 10117, Berlin, Germany. johannes.schulte@med.uni-tuebingen.de.; The German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. johannes.schulte@med.uni-tuebingen.de.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, 10178, Berlin, Germany. johannes.schulte@med.uni-tuebingen.de.; Department I - General Pediatrics, Hematology/Oncology, University Children's Hospital, Eberhard Karls University Tuebingen, 72076, Tuebingen, Germany. johannes.schulte@med.uni-tuebingen.de.

Publikováno v: Nature communications [Nat Commun] 2023 Jul 04; Vol. 14 (1), pp. 3936. Date of Electronic Publication: 2023 Jul 04.