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pro vyhledávání: '"Suellen Mary Samson"'
Autor:
Suellen Mary Samson, Thomas Dominick Ingolia, Jerry L. Chapman, Ramamoorthy Belagaje, Stephen Wyatt Queener
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 84(16)
The predicted amino acid sequences of isopenicillin N synthetase from both Cephalosporium acremonium and Penicillium chrysogenum have two cysteine residues in analogous positions (Cys-106 and Cys-255 in the C. acremonium numbering). To examine the ro
Autor:
R. Belagaje, Thomas D. Ingolia, Edward P. Abraham, David Perry, R. M. VanFrank, Suellen Mary Samson, Jack E. Baldwin, Stephen Wyatt Queener, Paul L. Skatrud, D. T. Blankenship, Jerry L. Chapman
Publikováno v:
Nature. 318(6042)
The enzyme isopenicillin N synthetase (IPS) catalyses the oxidative condensation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (LLD-ACV) to isopenicillin N, which is a central reaction in the pathway to clinically important penicillins and ceph