Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Suellen Gonçalves da Silva"'
Autor:
Bárbara Velame Ferreira Teixeira, André Lacerda Braga Teles, Suellen Gonçalves da Silva, Camila Carane Bitencourt Brito, Humberto Fonseca de Freitas, Acássia Benjamim Leal Pires, Thamires Quadros Froes, Marcelo Santos Castilho
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1439-1450 (2019)
Leishmaniasis is a tropical disease found in more than 90 countries. The drugs available to treat this disease have nonspecific action and high toxicity. In order to develop novel therapeutic alternatives to fight this ailment, pteridine reductase 1
Externí odkaz:
https://doaj.org/article/47ffbc257e684a07b0e2938f725d0f05
Autor:
Camila Carane Bitencourt Brito, Marcelo Santos Castilho, Acássia Benjamim Leal Pires, Humberto Fonseca de Freitas, Bárbara Velame Ferreira Teixeira, André Lacerda Braga Teles, Thamires Quadros Froes, Suellen Gonçalves da Silva
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1439-1450 (2019)
Leishmaniasis is a tropical disease found in more than 90 countries. The drugs available to treat this disease have nonspecific action and high toxicity. In order to develop novel therapeutic alternatives to fight this ailment, pteridine reductase 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ae33c1875d51103f83ba86e1874c44
Autor:
Evandro Italo Macêdo de Souza, Marcelo Santos Castilho, Suellen Gonçalves da Silva, Drielli Gomes Vital-Fujii, Thamires Quadros Froes, Samuel Silva da Rocha Pita, Gustavo Henrique Goulart Trossini, Franco Henrique Andrade Leite
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Despite the fact that Leishmania ssp are pteridine auxotrophs, Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) inhibitors are ineffective against Leishmania major. On the other hand Pteridine Reductase 1 (PTR1) inhibitors proved to be lethal t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d634f82e04cf7b7ad24f8212ef6f4cd0
https://pubmed.ncbi.nlm.nih.gov/28407565
https://pubmed.ncbi.nlm.nih.gov/28407565
Autor:
João Luiz Quirino da Silva Filho, Franco Henrique Andrade Leite, Julianna Ferreira Cavalcanti de Albuquerque, Dalci José Brondani, Suellen Gonçalves da Silva, Priscila Brandão Gomes da Silva Santiago, Antônio Rodolfo de Faria, Marcelo Santos Castilho, Rafael Matos Ximenes, Thamires Quadros Froes
Publikováno v:
European journal of medicinal chemistry. 123
Leishmania major , as other protozoan parasites, plague human kind since pre-historic times but it remains a worldwide ailment for which the therapeutic arsenal remains scarce. Although L. major is pteridine- and purine-auxotroph, well-established fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5c3e5e95d47622a89280741b8a393f
https://pubmed.ncbi.nlm.nih.gov/27517809
https://pubmed.ncbi.nlm.nih.gov/27517809