Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Suelen de Brito Nascimento"'
Autor:
Carolina Machado Macedo, Francis Monique de Souza Saraiva, Jéssica Isis Oliveira Paula, Suelen de Brito Nascimento, Débora de Souza dos Santos Costa, Paulo Roberto Ribeiro Costa, Ayres Guimarães Dias, Marcia Cristina Paes, Natália Pereira Nogueira
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Chagas disease, which is caused by Trypanosoma cruzi, establishes lifelong infections in humans and other mammals that lead to severe cardiac and gastrointestinal complications despite the competent immune response of the hosts. Furthermore, it is a
Externí odkaz:
https://doaj.org/article/9759abbd9b764df59acebd09a8b83b6a
Autor:
Solange L. de Castro, Mauricio Peixoto Cupello, Francisco do Vale Chaves e Mello, Alcione S. Carvalho, Suelen de Brito Nascimento, Monique Araújo de Brito, Kelly Salomão, Bruna Maria Castro Salomão Quaresma, Israel Felzenszwalb, Jéssica Isis Oliveira Paula, Marcelly Cristina Resende Pitombeira, Nubia Boechat, Marcia Cristina Paes, Patrícia P. Farias
Publikováno v:
European journal of medicinal chemistry. 186
The current treatment of Chagas disease is based on the use of two drugs, nifurtimox (Nfx) and benznidazole (Bnz), both of which present limited efficacy in the chronic stage of the disease and toxic side effects. Thus, the discovery of novel compoun