Imaging Sites of Inhibition of Proteolysis in Pathomimetic Human Breast Cancer Cultures by Light-Activated Ruthenium Compound.

Autor: Suelem D Ramalho, Rajgopal Sharma, Jessica K White, Neha Aggarwal, Anita Chalasani, Mansoureh Sameni, Kamiar Moin, Paulo C Vieira, Claudia Turro, Jeremy J Kodanko, Bonnie F Sloane

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0142527 (2015)

The cysteine protease cathepsin B has been causally linked to progression and metastasis of breast cancers. We demonstrate inhibition by a dipeptidyl nitrile inhibitor (compound 1) of cathepsin B activity and also of pericellular degradation of dye-q

Externí odkaz: https://doaj.org/article/94f2914f02d24e1b87d3ebbb3c50695a

Linear peptide analogues from Jatropha's orbitides promote migration of human neonatal foreskin fibroblasts in vitro and collagen deposition

Autor: Vanderlan da Silva Bolzani, Renata K. Andricopulo, Adriano D. Andricopulo, Paulo R. S. Sanches, Eduardo Maffud Cilli, Edilberto R. Silveira, Meri Emili F. Pinto, Suelem D. Ramalho

Publikováno v: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Journal of the Brazilian Chemical Society v.30 n.10 2019
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Journal of the Brazilian Chemical Society, Volume: 30, Issue: 10, Pages: 2153-2161, Published: 21 OCT 2019

Made available in DSpace on 2020-12-12T02:32:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01. Added 1 bitstream(s) on 2021-07-15T15:07:38Z : No. of bitstreams: 1 S0103-50532019001002153.pdf: 2794919 bytes, checksum: cd2b9335294d2b610a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e358a945899ed9883582d4f7d8c1238

Synthetic Chalcone Derivatives as Inhibitors of Cathepsins K and B, and Their Cytotoxic Evaluation

Autor: James Almada da Silva, Caio Yu dos Santos, Giulio Demetrius, Aline Bernades, Manoel Odorico de Moraes, Paulo C. Vieira, Caridad Noda-Perez, Kristiana Cerqueira Mousinho, Suelem D. Ramalho

Publikováno v: Chemistry & Biodiversity. 10:1999-2006

A series of chalcone derivatives, 1-15, were prepared by Claisen-Schmidt condensation and evaluated for their cytotoxicities on tumor cell lines and also against proteolytic enzymes such as cathepsins B and K. Of the compounds synthesized, (E)-3-(3,4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7935dce8f2ad99a8331f94463f21f4
https://doi.org/10.1002/cbdv.201200344

Evaluation of flavonols and derivatives as human cathepsin B inhibitor

Autor: Maria Inês Salgueiro Lima, Suelem D. Ramalho, M. Fátima das G. F. da Silva, João B. Fernandes, Paulo C. Vieira, Lorena R.F. de Sousa, Marcela Carmen de Melo Burger

Cathepsin B (catB) is a cysteine protease involved in tumour progression and represents a potential therapeutic target in cancer. Among the 15 evaluated extracts from cerrado biome, Myrcia lingua Berg. (Myrtaceae) extract demonstrated to be a source

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f329e935218da554b5664992afd9552

Isolation of arginase inhibitors from the bioactivity-guided fractionation of Byrsonima coccolobifolia leaves and stems

Autor: Maria Inês Salgueiro Lima, Lorena R.F. de Sousa, Suelem D. Ramalho, Mônica Rosas da Costa Iemma, Caroindes Julia Corrêa, João B. Fernandes, Paulo C. Vieira, Liliane Nebo, Marcela Carmen de Melo Burger, Dulce Helena Ferreira de Souza, Maria Fátima das Graças Fernandes da Silva

Publikováno v: Journal of natural products. 77(2)

Byrsonima coccolobifolia leaf and stem extracts were studied in the search for possible leishmanicidal compounds using arginase (ARG) from Leishmania amazonensis as a molecular target. Flavonoids 1b, 1e-1g, 2a, 2b, and 2d-2f showed significant inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccda2e3be20619292cb77690763d2e4
https://pubmed.ncbi.nlm.nih.gov/24521209