Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Suela Xhani"'
Autor:
J. Ross Terrell, Samuel J. Taylor, Amelia L. Schneider, Yue Lu, Tyler N. Vernon, Suela Xhani, Ryan H. Gumpper, Ming Luo, W. David Wilson, Ulrich Steidl, Gregory M.K. Poon
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112671- (2023)
Summary: The master transcriptional regulator PU.1/Spi-1 engages DNA sites with affinities spanning multiple orders of magnitude. To elucidate this remarkable plasticity, we have characterized 22 high-resolution co-crystallographic PU.1/DNA complexes
Externí odkaz:
https://doaj.org/article/3a08b530979c4b649e48bbf830396248
Publikováno v:
J Biol Chem
Functional evidence increasingly implicates low-affinity DNA recognition by transcription factors as a general mechanism for the spatiotemporal control of developmental genes. Although the DNA sequence requirements for affinity are well-defined, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9a1d8484ace078536c59a62c842e7b
https://doi.org/10.1074/jbc.ra119.007866
https://doi.org/10.1074/jbc.ra119.007866
Autor:
Natasha L. Rudy, Anna C.E. Hurst, Alexander Marson, Steven H. Kroft, James Garifallou, Sarah K. Nicholas, Piyush Pillarisetti, Gerald Wertheim, Di Sun, Andrew D. Wells, Titus J. Boggon, Gregory M.K. Poon, Kelly Maurer, Brian Nolan, Caroline Khanna, Francis Wright, Jennifer M. Puck, Struan F.A. Grant, Suela Xhani, Amy Rymaszewski, Ivan K. Chinn, Viktoria Zakharova, Samuel Yoon, James W. Verbsky, Neil Romberg, David N. Nguyen, Linda T. Vo, Kathleen E. Sullivan, Chun Su, Anna Shcherbina, Alix E. Seif, T. Prescott Atkinson, Amy L. Stiegler, Hakon Hakonarson, Anna Mukhina, Amanda V. Albrecht, Timothy S. Olson, Peixin Amy Chen, John M. Routes, Benjamin Demaree, Joud Hajjar, James R. Lupski, Adam R. Abate, Michael Gonzalez, Carole Le Coz
Publikováno v:
Journal of Experimental Medicine. 218
The pioneer transcription factor (TF) PU.1 controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing nonpioneer TFs to enter otherwise inaccessible genomic sites. PU.1 deficiency fatally arrests lymphopoiesis and myelopo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30f4dc0a4c4b9707b814c76958472437
https://doi.org/10.1084/jem.20201750
https://doi.org/10.1084/jem.20201750
Intrinsic disorder controls two functionally distinct dimers of the master transcription factor PU.1
Autor:
Siming Wang, Suela Xhani, Markus W. Germann, Van L.T. Ha, James M. Aramini, Sang-Choon Lee, Amanda V. Albrecht, Shingo Esaki, Hye Mi Kim, Giselle L. Fernandez, Mahtab Khanezarrin, Gregory M.K. Poon
Publikováno v:
Science Advances
Distinct dimeric forms of PU.1 mutually antagonize to control the transcriptionally active dose via a disordered PEST domain.
Transcription factors comprise a major reservoir of conformational disorder in the eukaryotic proteome. The hematopoiet
Transcription factors comprise a major reservoir of conformational disorder in the eukaryotic proteome. The hematopoiet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d39028065d6482f06a50b91ec367af
https://doi.org/10.1126/sciadv.aay3178
https://doi.org/10.1126/sciadv.aay3178
Autor:
Kenneth Huang, Abdelbasset A. Farahat, Noa Erlitzki, Suela Xhani, Arvind Kumar, Gregory M.K. Poon, David W. Boykin
Publikováno v:
Biophysical Chemistry. 231:95-104
Previous investigations of sequence-specific DNA binding by model minor groove-binding compounds showed that the ligand/DNA complex was destabilized in the presence of compatible co-solutes. Inhibition was interpreted in terms of osmotic stress theor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c22f7ad43cb8e77c170b29a8ef4840
https://doi.org/10.1016/j.bpc.2017.02.008
https://doi.org/10.1016/j.bpc.2017.02.008
Publikováno v:
The Journal of Physical Chemistry B. 121:2748-2758
The ETS family of transcription factors is a functionally heterogeneous group of gene regulators that share a structurally conserved, eponymous DNA-binding domain. Unlike other ETS homologues, such as Ets-1, DNA recognition by PU.1 is highly sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58435ffbbbec7322c1c3a7b3ed315865
https://doi.org/10.1021/acs.jpcb.7b00325
https://doi.org/10.1021/acs.jpcb.7b00325
Autor:
Raul E. Salinas, Gregory M.K. Poon, Mimi Fang, Zachery Mielko, Suela Xhani, Alon Senitzki, Hashim M. Al-Hashimi, Maria A. Schumacher, Miles A. Pufall, Atul Rangadurai, Tali E. Haran, Honglue Shi, Raluca Gordân, Harshit Sahay, Ariel Afek
Publikováno v:
Nature
Transcription factors recognize specific genomic sequences to regulate complex gene-expression programs. Although it is well-established that transcription factors bind to specific DNA sequences using a combination of base readout and shape recogniti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1e7de883a8dab8a462a4549cee163b
https://pubmed.ncbi.nlm.nih.gov/33087865
https://pubmed.ncbi.nlm.nih.gov/33087865
Publikováno v:
Biophysical Journal. 118:74a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e1fda5e2ada564ce2fdf5e2fcb03693
https://doi.org/10.1016/j.bpj.2019.11.577
https://doi.org/10.1016/j.bpj.2019.11.577
Publikováno v:
Biophysical Journal. 116:486a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d84426533b6da4161c40c097bb6fce44
https://doi.org/10.1016/j.bpj.2018.11.2625
https://doi.org/10.1016/j.bpj.2018.11.2625
Publikováno v:
Biophysical Journal. 110(3):236a-237a
In systems biology, molecular titration is a mechanism for introducing sensitivity of genetic networks to their regulatory proteins. Since most eukaryotic transcription factors lack chemical control by low-molecular-weight hormones or metabolites, tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08fa9283bc0cb6cca89471da3d41d271