Zobrazeno 1 - 10 of 163 pro vyhledávání: '"Sue-Jane Wang"'
1
Akademický článek
Utility of Adaptive Strategy and Adaptive Design for Biomarker-facilitated Patient Selection in Pharmacogenomic or Pharmacogenetic Clinical Development Program
Autor: Sue-Jane Wang
Publikováno v: Journal of the Formosan Medical Association, Vol 107, Iss 12, Pp S19-S27 (2008)
In the early to late phases of conventional clinical trials, improvement of disease status at study baseline is the anchor of an effective treatment measured by therapeutic response. These population-based clinical trials do not formally account for
Externí odkaz: https://doaj.org/article/971d10410a094be6bce627105e2b2086
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2
Akademický článek
Quantitative Brain Amyloid PET.
Autor: Jagust, William J., Mattay, Venkata S., Krainak, Daniel M., Sue-Jane Wang, Weidner, Lora D., Hofling, A. Alex, Hayoung Koo, Hsieh, Pamela, Kuo, Phillip H., Farrar, Gill, Marzella, Libero
Publikováno v: Journal of Nuclear Medicine; Aug2024, Vol. 65 Issue 8, p1-9, 9p
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5
Bayesian Sample Size Planning Tool for Phase I Dose-Finding Trials
Autor: Xiaolei Lin, Jiaying Lyu, Shijie Yuan, Dehua Bi, Sue-Jane Wang, Yuan Ji
Publikováno v: JCO Precision Oncology.
PURPOSE Through Bayesian inference, we propose a method called BayeSize as a reference tool for investigators to assess the sample size and its associated scientific property for phase I clinical trials. METHODS BayeSize applies the concept of effect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5739025d13e53139f6c2449a2675b3
https://doi.org/10.1200/po.22.00046
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6
Perspectives on statistical strategies for the regulatory biomarker qualification process
Autor: Sue Jane Wang, Suzanne Hendrix, Klaus Romero, Aloka Chakravarty, John-Michael Sauer, Samuel P. Dickson, Lisa M. McShane, Robin Mogg
Publikováno v: Biomarkers in Medicine
Qualification of a biomarker for use in a medical product development program requires a statistical strategy that aligns available evidence with the proposed context of use (COU), identifies any data gaps to be filled and plans any additional resear
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ada180c1e3ade7afb533f79ed6c4acc
http://europepmc.org/articles/PMC8293027
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8
Akademický článek
A simple and efficient algorithm for genome‐wide homozygosity analysis in disease
Autor: Wei Liu, Jinhui Ding, Jesse Raphael Gibbs, Sue Jane Wang, John Hardy, Andrew Singleton
Publikováno v: Molecular Systems Biology, Vol 5, Iss 1, Pp 1-6 (2009)
Abstract Here we propose a simple statistical algorithm for rapidly scoring loci associated with disease or traits due to recessive mutations or deletions using genome‐wide single nucleotide polymorphism genotyping case–control data in unrelated
Externí odkaz: https://doaj.org/article/5db228bb56624e238b2e949d2526c93e
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9
A Trans-Agency Workshop on the Pathophysiology of Radiation-Induced Lung Injury
Autor: Paul W. Price, Banu A Karimi-Shah, Libero Marzella, Merriline M. Satyamitra, Sue-Jane Wang, Nushin Todd, David R. Cassatt, Rosemary Roberts, Alex Gorovets
Publikováno v: Radiat Res
Research and development of medical countermeasures (MCMs) for radiation-induced lung injury relies on the availability of animal models with well-characterized pathophysiology, allowing effective bridging to humans. To develop useful animal models,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07a6fab10e2e8a441a31b453376e06d
https://pubmed.ncbi.nlm.nih.gov/34342637
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