Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sue-Ing Lin"'
Autor:
Joel M. Harris, Xiaoping Zhou, John A. Morrow, Sue-Ing Lin, Marco A. S. Baptista, John M. Sanders, Xiaoping Zhang, Hong Mei, Mark W. Embrey, Sylvie M. Sur, Duane E. DeMong, Ravi P. Nargund, Alan Hruza, Heather E. Tiscia, Matthew J. Fell, Zhizhang Yin, Gautam Agnihotri, Honglu Zhang, Thomas J. Greshock, Jack D. Scott, Yinghui Lin, Zhi-Cai Shi, John A. Mccauley, Sarah W. Li, Ronald K. Chang, Mark T. Bilodeau, Michael W. Miller, Reshma Kuvelkar, Andrew Stamford, Marc Poirier, Hong Liu, Megan K. Macala, Kallol Basu, Li Xiao, Lynn A. Hyde, Jonathan T. Kern, Xing Dai, Christian Mirescu, Paul L. Walsh, Matthew E. Kennedy, John J. Renger, Zhiyong Hu, John Columbus, Robert E. Drolet, Eric M. Parker
Publikováno v:
Journal of medicinal chemistry. 60(7)
Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein which contains a kinase domain and GTPase domain among other regions. Individuals possessing gain of function mutations in the kinase domain such as the most prevalent G2019S mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2ca3dd5156b7d725b7ec9d610b7b59
https://pubmed.ncbi.nlm.nih.gov/28245354
https://pubmed.ncbi.nlm.nih.gov/28245354
Autor:
Jean E. Lachowicz, Kung-I Feng, Joyce J. Hwa, Jitendra D. Belani, Michael Wong, Ling Kang, Diane Grotz, Wensheng Yu, Sue-Ing Lin, Yang Cao, Andrew Stamford, Richard A. Morrison, Peishan Lin, Duane E. DeMong, Hongtao Zhang, Peng Dai, Jolicia Gauuan, Christopher Sondey, Joseph A. Kozlowski, He Zhao, Mark Liang, Ying Zhai, Brian J. Lavey, Xing Dai, Aileen Soriano, Tao Meng, Ping Chen, De-Yi Yang, William J. Greenlee, Bradley Prudence K, Kathleen Cox, Bhuneshwari Patel, Paul McNamara, Jesse K. Wong, Michael W. Miller, Guowei Zhou, Teresa Andreani
Publikováno v:
Journal of Medicinal Chemistry. 57:2601-2610
A novel series of spiroimidazolone-based antagonists of the human glucagon receptor (hGCGR) has been developed. Our efforts have led to compound 1, N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazasp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d79521da6469de081b15fb4cf46d71d
https://doi.org/10.1021/jm401858f
https://doi.org/10.1021/jm401858f
Autor:
Tony Priestley, Vaccaro Henry A, Andrew Stamford, Deborra E Mullins, Michael W. Miller, Tin-Yau Chan, Robert A. Hodgson, Scott Jack D, William J. Greenlee, Liwu Hong, Mario Guzzi, Sarah W. Li, Eric M. Parker, Geoffrey B. Varty, Jay Weinstein, Sue-Ing Lin, Mckittrick Brian A
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6018-6022
Vasopressin 1b (V1b) antagonists have been postulated as possible treatments for depression and anxiety. A novel series of potent and selective V1b antagonists has been identified starting from an in-house screen hit. The incorporation of a sulfonami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1a83509d9b8d8b7220d92453c7462a
https://doi.org/10.1016/j.bmcl.2009.09.050
https://doi.org/10.1016/j.bmcl.2009.09.050
Autor:
Duane, DeMong, Xing, Dai, Joyce, Hwa, Michael, Miller, Sue-Ing, Lin, Ling, Kang, Andrew, Stamford, William, Greenlee, Wensheng, Yu, Michael, Wong, Brian, Lavey, Joseph, Kozlowski, Guowei, Zhou, De-Yi, Yang, Bhuneshwari, Patel, Aileen, Soriano, Ying, Zhai, Christopher, Sondey, Hongtao, Zhang, Jean, Lachowicz, Diane, Grotz, Kathleen, Cox, Richard, Morrison, Teresa, Andreani, Yang, Cao, Mark, Liang, Tao, Meng, Paul, McNamara, Jesse, Wong, Prudence, Bradley, Kung-I, Feng, Jitendra, Belani, Ping, Chen, Peng, Dai, Jolicia, Gauuan, Peishan, Lin, He, Zhao
Publikováno v:
Journal of medicinal chemistry. 57(6)
A novel series of spiroimidazolone-based antagonists of the human glucagon receptor (hGCGR) has been developed. Our efforts have led to compound 1, N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazasp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7428e9b03dd835df4d86fffa2b642e9e
https://pubmed.ncbi.nlm.nih.gov/24527772
https://pubmed.ncbi.nlm.nih.gov/24527772
Autor:
Michael G. Murray, Bernard R. Neustadt, Julie M. Strizki, Sue-Ing Lin, Nicole Vantuno, Lisa Wojcik, Jayaram R. Tagat, Kathleen Cox, and Bahige M. Baroudy, Steensma Ruo, Dennis V. Nazareno, Stuart W. McCombie, Serena Xu
Publikováno v:
Journal of Medicinal Chemistry. 44:3343-3346
Truncation of the original piperidino-2(S)-methyl piperazine lead structure 2, from a family of muscarinic antagonists, gave compound 8 which has improved selectivity for the HIV-1 co-receptor CCR5 over muscarinic receptors. Further optimization for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13d3fd3d509d230c7eb1b4a8a60a7827
https://doi.org/10.1021/jm0155401
https://doi.org/10.1021/jm0155401
Autor:
Dennis V. Nazareno, Stuart W. McCombie, Bahige M. Baroudy, Jayaram R. Tagat, Steensma Ruo, Serena Xu, Sue-Ing Lin, Nicole Vantuno, Jia Liu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2143-2146
Optimization of the piperidino-piperazines 1 and 2 provided early leads 3 and 4, which showed good activity in the CCR5–RANTES binding assay and in antiviral assays. A systematic study around these structures showed that the 2(S)-methyl piperazine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa9f48d8d60af12dd8a81e32c5ce804
https://doi.org/10.1016/s0960-894x(01)00381-x
https://doi.org/10.1016/s0960-894x(01)00381-x
Autor:
Kirkup Michael P, Bandarpalle B. Shankar, John W. Clader, Keith Huie, Sue-Ing Lin, Harry R. Davis, Douglas S Compton, Stuart W. McCombie, Andrew T. McPhail, Margaret van Heek, Yumibe Nathan P, Razia Rizvi, Sundeep Dugar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2069-2072
Previous SAR studies of C-3 side chain modified analogs of (−)-SCH 48461, 1,3,4 as well as information concerning the metabolic stability this series, enabled us to design a cholesterol absorption inhibitor (i.e., (−) 2a, SCH 57939) with tenfold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1110e2e0b2531fce1b60f72f94d4e12
https://doi.org/10.1016/0960-894x(96)00365-4
https://doi.org/10.1016/0960-894x(96)00365-4
Autor:
Mark E. Snow, Sue-Ing Lin, Stuart W. McCombie, Harry R. Davis, Sundeep Dugar, Kirkup Michael P, John W. Clader, Razia Rizvi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2947-2952
Our search for potent cholesterol absorption inhibitors led to the discovery of the β-lactam SCH 48461. Structure activity relationship studies prompted us to this study of γ-lactams, ring homologs of β-lactam SCH 48461, to determine their potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b99ff499e3f36aa5927d24f3b12e1363
https://doi.org/10.1016/0960-894x(95)00516-6
https://doi.org/10.1016/0960-894x(95)00516-6
Autor:
Stuart W. McCombie, Oswald Wilson, Kirkup Michael P, Karen Rosinski, Sue-Ing Lin, Robert Bishop, Bandarpalle B. Shankar, Paul Kirschmeier, Emily Dobek, Joanne M. Petrin, Donna Carr
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1537-1542
The condensation of indolo[2,3-a]-carbazole (12) with 2,5-dimethoxytetrahydrofuran derivatives gave cyclofuranosylated compounds (e.g. 13), which were converted via dibromocompounds to the dinitriles (e.g. 25). Hydrolysis, hydrolysis-reduction and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::939084d47bf3f57a87b0aac1ea2e9285
https://doi.org/10.1016/s0960-894x(00)80013-x
https://doi.org/10.1016/s0960-894x(00)80013-x
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a62427afc40e772b292b0d32057e2f5
https://doi.org/10.1002/chin.199329156
https://doi.org/10.1002/chin.199329156