Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sue Varmuza"'
Autor:
Andrea Jurisicova, Robert F. Casper, Sue Varmuza, Ingrid Lai, Alagammal Perumalsamy, Jacqui Detmar, Roxanne Fernandes
Publikováno v:
FEBS Journal. 277:1219-1233
Elevated cell death in human preimplantation embryos is one of the cellular events compromising pregnancy rates after assisted reproductive technology treatments. We therefore explored the molecular pathways regulating cell death at the blastocyst st
Autor:
Sue Varmuza, Ian M. Rogers
Publikováno v:
Molecular Reproduction and Development. 55:387-392
Chimera and cell marking studies suggest that axial determination in mouse embryos occurs at postimplantation stages. In contrast, Xenopus laevis axes are determined early due to the asymmetric distribution of maternally derived factors in the one-ce
Autor:
Ian M. Rogers, Sue Varmuza
Publikováno v:
Molecular Reproduction and Development. 45:163-170
The commonly accepted mechanism by which LiCl dorsalizes amphibian embryos is a respecification of ventral blastomeres, presumably through realignment of dorsal positional information in the embryo. An alternative mechanism, however, is an epigenetic
Autor:
Alagammal, Perumalsamy, Roxanne, Fernandes, Ingrid, Lai, Jacqui, Detmar, Sue, Varmuza, Robert F, Casper, Andrea, Jurisicova
Publikováno v:
The FEBS journal. 277(5)
Elevated cell death in human preimplantation embryos is one of the cellular events compromising pregnancy rates after assisted reproductive technology treatments. We therefore explored the molecular pathways regulating cell death at the blastocyst st
Publikováno v:
Molecular human reproduction. 9(3)
In order to resolve the mechanisms and reasons of cellular fragmentation it is crucial to understand what genes may be responsible for regulation of this process. We report herein that human oocytes and preimplantation embryos possess abundant levels
Autor:
Keith E. Latham, Arnold H. Greenberg, Andrea Jurisicova, Louise Bergeron, Lianfa Shi, Junying Yuan, Jodi A. Flaws, Sue Varmuza, Gloria I. Perez, En Li, Glen C. Macdonald, Jonathan L. Tilly, Yi Sun, Jessica C.M. Salter, Michael A. Moskowitz, Hideaki Hara
Publikováno v:
Genesdevelopment. 12(9)
During embryonic development, a large number of cells die naturally to shape the new organism. Members of the caspase family of proteases are essential intracellular death effectors. Herein, we generated caspase-2-deficient mice to evaluate the requi
Publikováno v:
Developmental genetics. 20(1)
Thp is a large deletion on chromosome 17 which includes the maternal lethal gene Tme. Documentation of inheritance patterns suggests that Tme is an imprinted gene which is required for viability; maternal deletion is lethal while paternal deletion is
Publikováno v:
Developmental genetics. 17(3)
Uniparental embryos have been instrumental in studying imprinting because contributions from the parental genomes can be determined unambiguously. In this study, we set out to identify imprinted genes showing differential expression between parthenog
Autor:
Mellissa R.W. Mann, Sue Varmuza
Publikováno v:
Trends in genetics : TIG. 10(4)
Why do mammals imprint their parental genomes? Imprinting is seen in many phyla, but that in mammals is by far the most dramatic. Is there something peculiar to mammals that calls for such a striking phenomenon? We propose that imprinting is a device
Publikováno v:
Mammalian genome : official journal of the International Mammalian Genome Society. 3(4)
Retinoic acid is essential for normal development and growth of structures such as head and limbs, and it can act as morphogen or teratogen. Retinoic acid induces expression of genes such as the homeobox genes and keratin type I and type II genes. Re