Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array.

Autor: Siim Sõber, Elin Org, Katrin Kepp, Peeter Juhanson, Susana Eyheramendy, Christian Gieger, Peter Lichtner, Norman Klopp, Gudrun Veldre, Margus Viigimaa, Angela Döring, Kooperative Gesundheitsforschung in der Region Augsburg Study, Margus Putku, Piret Kelgo, HYPertension in ESTonia Study, Sue Shaw-Hawkins, Philip Howard, Abiodun Onipinla, Richard J Dobson, Stephen J Newhouse, Morris Brown, Anna Dominiczak, John Connell, Nilesh Samani, Martin Farrall, MRC British Genetics of Hypertension Study, Mark J Caulfield, Patricia B Munroe, Thomas Illig, H-Erich Wichmann, Thomas Meitinger, Maris Laan

Publikováno v: PLoS ONE, Vol 4, Iss 6, p e6034 (2009)

The outcome of Genome-Wide Association Studies (GWAS) has challenged the field of blood pressure (BP) genetics as previous candidate genes have not been among the top loci in these scans. We used Affymetrix 500K genotyping data of KORA S3 cohort (n =

Externí odkaz: https://doaj.org/article/ef94bebe2af8403fadc7eb137e315483

SLC2A9 is a high-capacity urate transporter in humans.

Autor: Mark J Caulfield, Patricia B Munroe, Deb O'Neill, Kate Witkowska, Fadi J Charchar, Manuel Doblado, Sarah Evans, Susana Eyheramendy, Abiodun Onipinla, Philip Howard, Sue Shaw-Hawkins, Richard J Dobson, Chris Wallace, Stephen J Newhouse, Morris Brown, John M Connell, Anna Dominiczak, Martin Farrall, G Mark Lathrop, Nilesh J Samani, Meena Kumari, Michael Marmot, Eric Brunner, John Chambers, Paul Elliott, Jaspal Kooner, Maris Laan, Elin Org, Gudrun Veldre, Margus Viigimaa, Francesco P Cappuccio, Chen Ji, Roberto Iacone, Pasquale Strazzullo, Kelle H Moley, Chris Cheeseman

Publikováno v: PLoS Medicine, Vol 5, Iss 10, p e197 (2008)

BackgroundSerum uric acid levels in humans are influenced by diet, cellular breakdown, and renal elimination, and correlate with blood pressure, metabolic syndrome, diabetes, gout, and cardiovascular disease. Recent genome-wide association scans have

Externí odkaz: https://doaj.org/article/892e31dab58f42d181e0f0303866af71

Evaluating a process of academic detailing in primary care: an educational programme for acute kidney injury

Autor: Joanna C. McKinnell, Rebecca Noble, Sally Bassett, Lynn Woods, Mufaza Asrar, Nicholas M. Selby, Sue Shaw, Nitin V. Kolhe

Publikováno v: BMC Medical Education, Vol 19, Iss 1, Pp 1-8 (2019)
BMC Medical Education

Background Primary care has a significant role in AKI management: two-thirds of AKI originates in the community. Through academic detailing (an evidence-based educational approach) we aimed to implement and measure the effect of a primary care-based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b5d1bf9bca923f9d064b63ffeb85f0
http://link.springer.com/article/10.1186/s12909-019-1659-y

A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies

Autor: Corneliu A. Bodea, Benjamin M. Neale, Stephan Ripke, Mark J. Daly, Bernie Devlin, Kathryn Roeder, Murray Barclay, Laurent Peyrin-Biroulet, Mathias Chamaillard, Jean-Frederick Colombel, Mario Cottone, Anthony Croft, Renata D’Incà, Jonas Halfvarson, Katherine Hanigan, Paul Henderson, Jean-Pierre Hugot, Amir Karban, Nicholas A. Kennedy, Mohammed Azam Khan, Marc Lémann, Arie Levine, Dunecan Massey, Monica Milla, Grant W. Montgomery, Sok Meng Evelyn Ng, Ioannis Oikonomou, Harald Peeters, Deborah D. Proctor, Jean-Francois Rahier, Rebecca Roberts, Paul Rutgeerts, Frank Seibold, Laura Stronati, Kirstin M. Taylor, Leif Törkvist, Kullak Ublick, Johan Van Limbergen, Andre Van Gossum, Morten H. Vatn, Hu Zhang, Wei Zhang, Jane M. Andrews, Peter A. Bampton, Timothy H. Florin, Richard Gearry, Krupa Krishnaprasad, Ian C. Lawrance, Gillian Mahy, Graham Radford-Smith, Rebecca L. Roberts, Lisa A. Simms, Leila Amininijad, Isabelle Cleynen, Olivier Dewit, Denis Franchimont, Michel Georges, Debby Laukens, Emilie Theatre, André Van Gossum, Severine Vermeire, Guy Aumais, Leonard Baidoo, Arthur M. Barrie, Karen Beck, Edmond-Jean Bernard, David G. Binion, Alain Bitton, Steve R. Brant, Judy H. Cho, Albert Cohen, Kenneth Croitoru, Lisa W. Datta, Colette Deslandres, Richard H. Duerr, Debra Dutridge, John Ferguson, Joann Fultz, Philippe Goyette, Gordon R. Greenberg, Talin Haritunians, Gilles Jobin, Seymour Katz, Raymond G. Lahaie, Dermot P. McGovern, Linda Nelson, Sok Meng Ng, Kaida Ning, Pierre Paré, Miguel D. Regueiro, John D. Rioux, Elizabeth Ruggiero, L. Philip Schumm, Marc Schwartz, Regan Scott, Yashoda Sharma, Mark S. Silverberg, Denise Spears, A. Hillary Steinhart, Joanne M. Stempak, Jason M. Swoger, Constantina Tsagarelis, Clarence Zhang, Hongyu Zhao, Jan Aerts, Tariq Ahmad, Hazel Arbury, Anthony Attwood, Adam Auton, Stephen G. Ball, Anthony J. Balmforth, Chris Barnes, Jeffrey C. Barrett, Inês Barroso, Anne Barton, Amanda J. Bennett, Sanjeev Bhaskar, Katarzyna Blaszczyk, John Bowes, Oliver J. Brand, Peter S. Braund, Francesca Bredin, Gerome Breen, Morris J. Brown, Ian N. Bruce, Jaswinder Bull, Oliver S. Burren, John Burton, Jake Byrnes, Sian Caesar, Niall Cardin, Chris M. Clee, Alison J. Coffey, John M.C. Connell, Donald F. Conrad, Jason D. Cooper, Anna F. Dominiczak, Kate Downes, Hazel E. Drummond, Darshna Dudakia, Andrew Dunham, Bernadette Ebbs, Diana Eccles, Sarah Edkins, Cathryn Edwards, Anna Elliot, Paul Emery, David M. Evans, Gareth Evans, Steve Eyre, Anne Farmer, Nicol Ferrier, Edward Flynn, Alistair Forbes, Liz Forty, Jayne A. Franklyn, Timothy M. Frayling, Rachel M. Freathy, Eleni Giannoulatou, Polly Gibbs, Paul Gilbert, Katherine Gordon-Smith, Emma Gray, Elaine Green, Chris J. Groves, Detelina Grozeva, Rhian Gwilliam, Anita Hall, Naomi Hammond, Matt Hardy, Pile Harrison, Neelam Hassanali, Husam Hebaishi, Sarah Hines, Anne Hinks, Graham A. Hitman, Lynne Hocking, Chris Holmes, Eleanor Howard, Philip Howard, Joanna M.M. Howson, Debbie Hughes, Sarah Hunt, John D. Isaacs, Mahim Jain, Derek P. Jewell, Toby Johnson, Jennifer D. Jolley, Ian R. Jones, Lisa A. Jones, George Kirov, Cordelia F. Langford, Hana Lango-Allen, G. Mark Lathrop, James Lee, Kate L. Lee, Charlie Lees, Kevin Lewis, Cecilia M. Lindgren, Meeta Maisuria-Armer, Julian Maller, John Mansfield, Jonathan L. Marchini, Paul Martin, Dunecan C.O. Massey, Wendy L. McArdle, Peter McGuffin, Kirsten E. McLay, Gil McVean, Alex Mentzer, Michael L. Mimmack, Ann E. Morgan, Andrew P. Morris, Craig Mowat, Patricia B. Munroe, Simon Myers, William Newman, Elaine R. Nimmo, Michael C. O’Donovan, Abiodun Onipinla, Nigel R. Ovington, Michael J. Owen, Kimmo Palin, Aarno Palotie, Kirstie Parnell, Richard Pearson, David Pernet, John R.B. Perry, Anne Phillips, Vincent Plagnol, Natalie J. Prescott, Inga Prokopenko, Michael A. Quail, Suzanne Rafelt, Nigel W. Rayner, David M. Reid, Anthony Renwick, Susan M. Ring, Neil Robertson, Samuel Robson, Ellie Russell, David St Clair, Jennifer G. Sambrook, Jeremy D. Sanderson, Stephen J. Sawcer, Helen Schuilenburg, Carol E. Scott, Richard Scott, Sheila Seal, Sue Shaw-Hawkins, Beverley M. Shields, Matthew J. Simmonds, Debbie J. Smyth, Elilan Somaskantharajah, Katarina Spanova, Sophia Steer, Jonathan Stephens, Helen E. Stevens, Kathy Stirrups, Millicent A. Stone, David P. Strachan, Zhan Su, Deborah P.M. Symmons, John R. Thompson, Wendy Thomson, Martin D. Tobin, Mary E. Travers, Clare Turnbull, Damjan Vukcevic, Louise V. Wain, Mark Walker, Neil M. Walker, Chris Wallace, Margaret Warren-Perry, Nicholas A. Watkins, John Webster, Michael N. Weedon, Anthony G. Wilson, Matthew Woodburn, B. Paul Wordsworth, Chris Yau, Allan H. Young, Eleftheria Zeggini, Matthew A. Brown, Paul R. Burton, Mark J. Caulfield, Alastair Compston, Martin Farrall, Stephen C.L. Gough, Alistair S. Hall, Andrew T. Hattersley, Adrian V.S. Hill, Christopher G. Mathew, Marcus Pembrey, Jack Satsangi, Michael R. Stratton, Jane Worthington, Matthew E. Hurles, Audrey Duncanson, Willem H. Ouwehand, Miles Parkes, Nazneen Rahman, John A. Todd, Nilesh J. Samani, Dominic P. Kwiatkowski, Mark I. McCarthy, Nick Craddock, Panos Deloukas, Peter Donnelly, Jenefer M. Blackwell, Elvira Bramon, Juan P. Casas, Aiden Corvin, Janusz Jankowski, Hugh S. Markus, Colin N.A. Palmer, Robert Plomin, Anna Rautanen, Richard C. Trembath, Ananth C. Viswanathan, Nicholas W. Wood, Chris C.A. Spencer, Gavin Band, Céline Bellenguez, Colin Freeman, Garrett Hellenthal, Matti Pirinen, Amy Strange, Hannah Blackburn, Suzannah J. Bumpstead, Serge Dronov, Matthew Gillman, Alagurevathi Jayakumar, Owen T. McCann, Jennifer Liddle, Simon C. Potter, Radhi Ravindrarajah, Michelle Ricketts, Matthew Waller, Paul Weston, Sara Widaa, Pamela Whittaker

Publikováno v: American journal of human genetics, Vol. 98, no. 5, p. 857-868 (2016)

A. Palotie on työryhmän Int IBD Genetics Consortium jäsen. One goal of human genetics is to understand the genetic basis of disease, a challenge for diseases of complex inheritance because risk alleles are few relative to the vast set of benign va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a716d5c3b5025121394e710e95819952
https://doi.org/10.1016/j.ajhg.2016.02.025

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

Autor: Anton J. M. de Craen, Catherine E. de Keyser, Xiaohui Li, Joshua C. Bis, Jerome I. Rotter, J. Wouter Jukema, Stephen S. Rich, Kerri L. Wiggins, Eoin O'Brien, Oscar H. Franco, Yongmei Liu, Peter S. Sever, André G. Uitterlinden, Ching-Ti Liu, Michael R. Barnes, P. Eline Slagboom, Daniel S. Evans, Bruce M. Psaty, L. Adrienne Cupples, Fernando Rivadeneira, Joshua C. Denny, Paul M. McKeigue, Neil R Poulter, Rudi G. J. Westendorp, Sue Shaw-Hawkins, Gudny Eiriksdottir, Paul N. Durrington, Alice M. Arnold, Ronald M. Krauss, Paul M. Ridker, Marie-Pierre Dubé, Graham A. Hitman, Til Stürmer, Jean-Claude Tardif, Christie M. Ballantyne, Christopher J. O'Donnell, Susan R. Heckbert, Eric A. Whitsel, Deborah A. Nickerson, Kenneth Rice, Russell A. Wilke, Benoit J. Arsenault, Nicholas L. Smith, Helen R. Warren, Steven R. Cummings, Helen M. Colhoun, Andrew Neil, Vilmundur Gudnason, QiPing Feng, Patricia B. Munroe, Eric Boerwinkle, Nona Sotoodehnia, Wei-Qi Wei, Colin N. A. Palmer, Christy L. Avery, Denis C. Shields, Ian Ford, Bruno H. Stricker, John Betteridge, David J. Stott, S. Matthijs Boekholdt, Thomas Lumley, Charles M. Stein, G. Kees Hovingh, Brendan M. Buckley, Albert V. Smith, Harshal Deshmukh, Y. D.I. Chen, Ramachandran S. Vasan, Naveed Sattar, Bryan J. Barratt, Tamara B. Harris, Albert Hofman, Stella Trompet, Wendy Post, Joshua D. Smith, Fredrik Nyberg, Alice Stanton, Mark J. Caulfield, Kent D. Taylor, Fangui Sun, Daniel I. Chasman, Jeanette M. Stafford, Roelof A.J. Smit, L. J. Launer, Iris Postmus, Xiuqing Guo, John J. P. Kastelein

Publikováno v: Journal of Medical Genetics, 53(12), 835
Journal of Medical Genetics, 53(12), 835-845. BMJ Publishing Group
Postmus, I, Warren, H R, Trompet, S, Arsenault, B J, Avery, C L, Bis, J C, Chasman, D I, de Keyser, C E, Deshmukh, H A, Evans, D S, Feng, Q, Li, X, Smit, R A J, Smith, A V, Sun, F, Taylor, K D, Arnold, A M, Barnes, M R, Barratt, B J, Betteridge, J, Boekholdt, S M, Boerwinkle, E, Buckley, B M, Chen, Y-D I, de Craen, A J M, Cummings, S R, Denny, J C, Dubé, M P, Durrington, P N, Eiriksdottir, G, Ford, I, Guo, X, Harris, T B, Heckbert, S R, Hofman, A, Hovingh, G K, Kastelein, J J P, Launer, L J, Liu, C-T, Liu, Y, Lumley, T, McKeigue, P M, Munroe, P B, Neil, A, Nickerson, D A, Nyberg, F, O'Brien, E, O'Donnell, C J, Post, W, Poulter, N, Vasan, R S, Rice, K, Rich, S S, Rivadeneira, F, Sattar, N, Sever, P, Shaw-Hawkins, S, Shields, D C, Slagboom, P E, Smith, N L, Smith, J D, Sotoodehnia, N, Stanton, A, Stott, D J, Stricker, B H, Stürmer, T, Uitterlinden, A G, Wei, W-Q, Westendorp, R G J, Whitsel, E A, Wiggins, K L, Wilke, R A, Ballantyne, C M, Colhoun, H M, Cupples, L A, Franco, O H, Gudnason, V, Hitman, G, Palmer, C N A, Psaty, B M, Ridker, P M, Stafford, J M, Stein, C M, Tardif, J-C, Caulfield, M J, Jukema, J W, Rotter, J I & Krauss, R M 2016, ' Meta-analysis of genome-wide association studies of HDL cholesterol response to statins ', Journal of Medical Genetics . https://doi.org/10.1136/jmedgenet-2016-103966
Journal of medical genetics, vol 53, iss 12
Journal of medical genetics, 53(12), 835-845. BMJ Publishing Group

BACKGROUND: In addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Inter-individual variation in HDL-C response to statins may be partially explained by gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe0a35109caf7e4148e155075671133
http://hdl.handle.net/1887/113227