Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Sue Shackleton"'
Autor:
Petra Mikolcevic, Michitaka Isoda, Hiroki Shibuya, Ivan del Barco Barrantes, Ana Igea, José A. Suja, Sue Shackleton, Yoshinori Watanabe, Angel R. Nebreda
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
CDKs play central roles in cell cycle regulation and are normally activated by cyclins. Here the authors show that RingoA induces a cyclin-independent function of CDK2 at meiotic telomeres, which regulates their tethering to the nuclear envelope and
Externí odkaz:
https://doaj.org/article/b5fefa9e561b4571b7f90454d487e1a7
Publikováno v:
F1000Research, Vol 6 (2017)
The centrosome is an unusual organelle that lacks a surrounding membrane, raising the question of what limits its size and shape. Moreover, while electron microscopy (EM) has provided a detailed view of centriole architecture, there has been limited
Externí odkaz:
https://doaj.org/article/77a4edf13a9a47d4942b3b12c842471a
Autor:
Peter Meinke, Elisabetta Mattioli, Farhana Haque, Susumu Antoku, Marta Columbaro, Kees R Straatman, Howard J Worman, Gregg G Gundersen, Giovanna Lattanzi, Manfred Wehnert, Sue Shackleton
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004605 (2014)
Proteins of the nuclear envelope (NE) are associated with a range of inherited disorders, most commonly involving muscular dystrophy and cardiomyopathy, as exemplified by Emery-Dreifuss muscular dystrophy (EDMD). EDMD is both genetically and phenotyp
Externí odkaz:
https://doaj.org/article/4bca2c034f45441aae30b4fef24970eb
Publikováno v:
Journal of Ophthalmology, Vol 2012 (2012)
Idiopathic infantile nystagmus (IIN) is an inherited disorder in which the nystagmus arises independently of any other symptoms, leading to the speculation that the disorder represents a primary defect in the area of the brain responsible for ocular
Externí odkaz:
https://doaj.org/article/7ef137fc46824fd88e924c868cb9cbdf
Publikováno v:
Journal of Cell Science; Sep2024, Vol. 137 Issue 17, p1-3, 3p
Autor:
Berta Casar, Xosé R. Bustelo, Paula Colón-Bolea, Sue Shackleton, Piero Crespo, Rocío García-Gómez
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecular Biology of the Cell
instname
Molecular Biology of the Cell
© 2020 Colón-Bolea et al.
RHO GTPases are key regulators of the cytoskeletal architecture, which impact a broad range of biological processes in malignant cells including motility, invasion, and metastasis, thereby affecting tumor progression.
RHO GTPases are key regulators of the cytoskeletal architecture, which impact a broad range of biological processes in malignant cells including motility, invasion, and metastasis, thereby affecting tumor progression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1573526ce8bb23587cf7c984c37f99d
http://hdl.handle.net/10261/230898
http://hdl.handle.net/10261/230898
Autor:
Michitaka Isoda, Sue Shackleton, Ivan del Barco Barrantes, Petra Mikolcevic, Hiroki Shibuya, Ana Igea, Angel R. Nebreda, José A. Suja, Yoshinori Watanabe
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Cyclin-dependent kinases (CDKs) play key roles in cell cycle regulation. Genetic analysis in mice has revealed an essential role for Cdk2 in meiosis, which renders Cdk2 knockout (KO) mice sterile. Here we show that mice deficient in RingoA, an atypic
Autor:
Can, Zhou, Chen, Li, Bin, Zhou, Huaqin, Sun, Victoria, Koullourou, Ian, Holt, Megan J, Puckelwartz, Derek T, Warren, Robert, Hayward, Ziyuan, Lin, Lin, Zhang, Glenn E, Morris, Elizabeth M, McNally, Sue, Shackleton, Li, Rao, Catherine M, Shanahan, Qiuping, Zhang
Publikováno v:
Human Molecular Genetics
Nesprins-1 and -2 are highly expressed in skeletal and cardiac muscle and together with SUN (Sad1p/UNC84)-domain containing proteins and lamin A/C form the LInker of Nucleoskeleton-and-Cytoskeleton (LINC) bridging complex at the nuclear envelope (NE)
Autor:
Radoslaw M. Sobota, Rutti Patel, Victoria Koullourou, Kamel Mamchaoui, Bruno Cadot, Brian Burke, Yin Loon Lee, François Nédélec, Jan Schmoranzer, Sue Shackleton, Edgar R. Gomes, Alessandra Calvi, Petra Gimpel
Publikováno v:
Current Biology-CB
Current Biology-CB, 2017, ⟨10.1016/j.cub.2017.08.031⟩
Current Biology
Current Biology-CB, Elsevier, 2017, ⟨10.1016/j.cub.2017.08.031⟩
Current Biology-CB, 2017, ⟨10.1016/j.cub.2017.08.031⟩
Current Biology
Current Biology-CB, Elsevier, 2017, ⟨10.1016/j.cub.2017.08.031⟩
Summary The nucleus is the main microtubule-organizing center (MTOC) in muscle cells due to the accumulation of centrosomal proteins and microtubule (MT) nucleation activity at the nuclear envelope (NE) [1, 2, 3, 4]. The relocalization of centrosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65fc6bee28e058751e48c956c20e128d
https://hal.sorbonne-universite.fr/hal-01598133
https://hal.sorbonne-universite.fr/hal-01598133
Autor:
Benjamin T. Goult, Rajashree Patil, Mervyn G Thomas, Rachel J. Watkins, Sue Shackleton, Irene Gottlob
Publikováno v:
Human Molecular Genetics
Idiopathic infantile nystagmus (IIN) is a genetically heterogeneous disorder of eye movement that can be caused by mutations in the FRMD7 gene that encodes a FERM domain protein. FRMD7 is expressed in the brain and knock-down studies suggest it plays