Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sue Metz"'
Autor:
John Robert Springer, Gina M. Jerome, Hayes Michael J, Michael T. Baratta, Daniel P. Walker, Graciela B. Arhancet, Alexander F. Shaffer, Jaime L. Masferrer, Ben S. Zweifel, Steven E. Heasley, Darin E. Jones, William M. Moore, Jeffrey S. Carter, Yvette M. Fobian, Michael L. Vazquez, Sue Metz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1114-1119
Inhibition of mPGES-1, the terminal enzyme in the arachidonic acid/COX pathway to regulate the production of pro-inflammatory prostaglandin PGE2, is considered an attractive new therapeutic target for safe and effective anti-inflammatory drugs. The d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b121fd58b89ecf308dd263c517c877ef
https://doi.org/10.1016/j.bmcl.2012.11.109
https://doi.org/10.1016/j.bmcl.2012.11.109
Autor:
Daniel P. Walker, Alexander F. Shaffer, William M. Moore, Michael T. Baratta, Sue Metz, Jeffrey A. Scholten, John Robert Springer, Jeffrey S. Carter, Hwang-Fun Lu, Steven E. Heasley, Yvette M. Fobian, Natasha M. Kablaoui, Francisco M. Franco, Li Xing, Shengtian Yang, Hanau Cathleen E, Michael L. Vazquez, Graciela B. Arhancet, Gina M. Jerome
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1120-1126
Microsomal prostaglandin E(2) synthase-1 (mPGES-1) is a novel therapeutic target for the treatment of inflammation and pain. In the preceding letter, we detailed the discovery of clinical candidate PF-04693627, a potent mPGES-1 inhibitor possessing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d05bf0698be13f2291735a95c4465f
https://doi.org/10.1016/j.bmcl.2012.11.107
https://doi.org/10.1016/j.bmcl.2012.11.107
Autor:
Ronald Keith Webber, William M. Moore, Pamela T. Manning, Sue Metz, Mihaly V. Toth, Alan E. Moormann, Gina M. Jerome, Donald W. Hansen, Christine Kornmeier, Barnett S. Pitzele
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2651-2653
The potency and selectivity of a series of 5-hetero-2-iminohexahydroazepines were examined as inhibitors of the three human NOS isoforms. The effect of ring substitution of the 5-carbon for a heteroatom is presented. Potencies (IC50's) for these inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9727b68b1b644f4201f4f9d03c3d37
https://doi.org/10.1016/s0960-894x(01)00523-6
https://doi.org/10.1016/s0960-894x(01)00523-6
Autor:
Alan E. Moormann, Donald W. Hansen, Gina M. Jerome, Sue Metz, Barnett S. Pitzele, Ronald Keith Webber, William M. Moore, Mihaly V. Toth, Pamela T. Manning, Christine Kornmeier
Publikováno v:
ChemInform. 33
The potency and selectivity of a series of 5-hetero-2-iminohexahydroazepines were examined as inhibitors of the three human NOS isoforms. The effect of ring substitution of the 5-carbon for a heteroatom is presented. Potencies (IC50's) for these inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b3946ff79ba2f2c48bff4fa5da1fe71
https://doi.org/10.1002/chin.200201177
https://doi.org/10.1002/chin.200201177