The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates

Autor: Claudia Buhigas, Anne Y. Warren, Wing-Kit Leung, Hayley C. Whitaker, Hayley J. Luxton, Steve Hawkins, Jonathan Kay, Adam Butler, Yaobo Xu, Dan J. Woodcock, Sue Merson, Fiona M. Frame, Atef Sahli, Federico Abascal, CRUK-ICGC Prostate Cancer Group, Iñigo Martincorena, G. Steven Bova, Christopher S. Foster, Peter Campbell, Norman J. Maitland, David E. Neal, Charlie E. Massie, Andy G. Lynch, Rosalind A. Eeles, Colin S. Cooper, David C. Wedge, Daniel S. Brewer

Publikováno v: Molecular Cancer, Vol 21, Iss 1, Pp 1-16 (2022)

Abstract Background Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal prostate predisposing to cancer development. In the present study we applied W

Externí odkaz: https://doaj.org/article/ab88a2ce376d486096a3008701e9592f

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

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Zechen, Chong, Oliver, Drechsel, Lewis Jonathan Dursi, Roland, Eils, Shadrielle M, G Espiritu, Robert, S Fulton, Shengjie, Gao, Josep L, L Gelpi, Mark, B Gerstein, Santiago, Gonzalez, Ivo, G Gut, Faraz, Hach, Michael, C Heinold, Jonathan, Hinton, Taobo, Hu, Vincent, Huang, Huang, Yi, Barbara, Hutter, David, R Jones, Jongsun, Jung, Natalie, Jäger, Hyung-Lae, Kim, Kortine, Kleinheinz, Sushant, Kumar, Yogesh, Kumar, Christopher, M Lalansingh, Ivica, Letunic, Dimitri, Livitz, Eric, Z Ma, Yosef, E Maruvka, R Jay Mashl, Andrew, Menzies, Ana, Milovanovic, Morten Muhlig Nielsen, Stephan, Ossowski, Nagarajan, Paramasivam, Jakob Skou Pedersen, Marc, D Perry, Montserrat, Puiggròs, Keiran, M Raine, Esther, Rheinbay, Romina, Royo, S Cenk Sahinalp, Iman, Sarrafi, Matthias, Schlesner, Jared, T Simpson, Lucy, Stebbings, Miranda, D Stobbe, Jon, W Teague, Grace, Tiao, David, Torrents, Jeremiah, A Wala, Jiayin, Wang, Sebastian, M Waszak, Joachim, Weischenfeldt, Michael, C Wendl, Johannes, Werner, 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Publikováno v: Nature Communications, 11(1):4748. Nature Publishing Group
Nature communications, 11(1):4748. Nature Publishing Group
Nature communications, 11 (1
NATURE COMMUNICATIONS
Nature Communications, 11 (1)
Nature Communications, Vol 11, Iss 1, Pp 1-27 (2020)
Bailey, M H, Meyerson, W U, Dursi, L J, Wang, L B, Dong, G, Liang, W W, Weerasinghe, A, Li, S, Kelso, S, Akbani, R, Anur, P, Bailey, M H, Buchanan, A, Chiotti, K, Covington, K, Creason, A, Ding, L, Weischenfeldt, J, Brunak, S, Ding, L, Favero, F, MC3 Working Group, PCAWG novel somatic mutation calling methods working group & PCAWG Consortium 2020, ' Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples ', Nature Communications, vol. 11, no. 1, 4748 . https://doi.org/10.1038/s41467-020-18151-y
Bailey, Matthew H; Meyerson, William U; Dursi, Lewis Jonathan; Wang, Liang-Bo; Dong, Guanlan; Liang, Wen-Wei; Weerasinghe, Amila; Li, Shantao; Kelso, Sean; Saksena, Gordon; Ellrott, Kyle; Wendl, Michael C; Wheeler, David A; Getz, Gad; Simpson, Jared T; Gerstein, Mark B; Ding, Li (2020). Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nature Communications, 11(1), p. 4748. Springer Nature 10.1038/s41467-020-18151-y
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Digital.CSIC. Repositorio Institucional del CSIC
Nature Communications, 11
RUO: Repositorio Institucional de la Universidad de Oviedo
Universidad de Oviedo (UNIOVI)
Bailey, M H, Meyerson, W U, Dursi, L J, Wang, L B, Dong, G, Liang, W W, Weerasinghe, A, Li, S, Kelso, S, Akbani, R, Anur, P, Bailey, M H, Buchanan, A, Chiotti, K, Covington, K, Creason, A, Ding, L, MC3 Working Group, PCAWG novel somatic mutation calling methods working group & PCAWG Consortium 2020, ' Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples ', Nature Communications, vol. 11, no. 1, 4748 . https://doi.org/10.1038/s41467-020-18151-y
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)

MC3 Working Group: Rehan Akbani21, Pavana Anur22, Matthew H. Bailey1,2,3, Alex Buchanan9, Kami Chiotti9, Kyle Covington12,23, Allison Creason9, Li Ding1,2,3,20, Kyle Ellrott9, Yu Fan21, Steven Foltz1,2, Gad Getz8,14,15,16, Walker Hale12, David Haussl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79caf69aa08507159a37977adcb4937b
https://www.bib.irb.hr/1104730

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets

Autor: Luke Marsden, Colin Cooper, Jorge Zamora, Barbara Kremeyer, Jonathan Kay, Steven Hazell, Mahbubl Ahmed, Tim Dudderidge, Edward Rowe, Hongwei Zhang, William Howat, Freddie C. Hamdy, Tapio Visakorpi, Paul C. Boutros, Gunes Gundem, Bissan Al-Lazikani, S. Edwards, David C. Wedge, Inigo Martincorena, Charles E. Massie, Douglas F. Easton, Gerhardt Attard, Nicholas van As, Anne Y. Warren, Dan J. Woodcock, Naomi Livni, Johann S. de Bono, Nening Dennis, Adam Lambert, Clare Verrill, Alan Thompson, Niedzica Camacho, Daniel Leongamornlert, William B. Isaacs, Christopher S. Foster, Hayley C. Whitaker, Pardeep Kumar, Daniel Brewer, Christopher Greenman, Declan Cahill, Simon Tavaré, Yong-Jie Lu, Stuart McLaren, Ultan McDermott, David T. Jones, Sue Merson, Rosalind A. Eeles, Vincent Khoo, Steve Hawkins, Daniel M. Berney, Cyril Fisher, Hayley J. Luxton, Lucy Matthews, Ludmil B. Alexandrov, G. Steven Bova, Adam Butler, David Nicol, Andy G. Lynch, Michael Fraser, Tokhir Dadaev, Keiran Raine, Mohammed J. R. Ghori, Katalin Karaszi, Jon W. Teague, Chris Sander, Robert G. Bristow, Peter Van Loo, Nimish Shah, Chris Ogden, Paul Workman, Andrew Menzies, Lucy Stebbings, Stefan C. Dentro, Cathy Corbishley, Thomas J. Mitchell, Zsofia Kote-Jarai, Pelvender Gill, Andrew Futreal, Elizabeth Bancroft, David E. Neal, Sarah Thomas, Anthony C. H. Ng, Erik Mayer, Yongwei Yu, Vincent Gnanapragasam, Valeria Bo

Publikováno v: Nature genetics, vol 50, iss 5

Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 primary and metastatic prostate cancer samples. From joint analysis of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3ffd6b6e74bb3d2b3dcdbbf64a4967
http://ora.ox.ac.uk/objects/uuid:

Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer

Autor: Henrik Møller, Jeremy Clark, Daniel Brewer, Jack Cuzick, Colin Cooper, David Olmos, Christopher S. Foster, Peter T. Scardino, Frank McCarthy, A. Eichholz, Daniel M. Berney, Gyula Kovacs, Sue Merson, Z. H. Yang, Gabrielle Fisher

Publikováno v: British Journal of Cancer

Background: Androgen receptor (AR)-gene amplification, found in 20–30% of castration-resistant prostate cancer (CRPCa) is proposed to develop as a consequence of hormone-deprivation therapy and be a prime cause of treatment failure. Here we investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0412ec9d3409f1325f83f84a57662ed
https://doi.org/10.1038/bjc.2014.13

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

Autor: Michael R. Stratton, Gunes Gundem, Victoria Goody, Laura Mudie, Cyril Fisher, Olivia Joseph, Stuart McLaren, Colin Cooper, Ben Robinson, Andrew Futreal, Paul C. Boutros, Rachel Hurst, Pardeep Kumar, Lucy Matthews, Daniel Leongamornlert, Charles E. Massie, Ludmil B. Alexandrov, Robert G. Bristow, Adam Butler, Mark Maddison, Rosalind A. Eeles, Hayley J. Luxton, David Nicol, Serena Nik-Zainal, Jon W. Teague, Jeremy Clark, Christopher Greenman, Douglas F. Easton, Chris Ogden, Peter Van Loo, Zsofia Kote-Jarai, Michael Fraser, Elizabeth Anderson, Hayley C. Whitaker, Ultan McDermott, Susanna L. Cooke, Barbara Kremeyer, Andrew Menzies, Daniel Brewer, David E. Neal, Anne Y. Warren, Naomi Livni, Manasa Ramakrishna, Jon Hinton, Niedzica Camacho, Andy G. Lynch, Richard Mithen, Jonathan Kay, Claire Hardy, Daniel M. Berney, Vincent Gnanapragasam, Jorge Zamora, Sarah Thomas, Erik Mayer, Thierry Voet, S. Edwards, Peter J. Campbell, Stephen J. Gamble, Cathy Corbishley, Steven Hazell, Keiran Raine, Tim Dudderidge, Nimish Shah, Sarah O’Meara, David T. Jones, C. R. J. Woodhouse, Christopher S. Foster, Sue Merson, David C. Wedge, Lucy Stebbings, Nening Dennis, Alan Thompson

Publikováno v: Nature genetics, vol 47, iss 4
Nature genetics

© 2015 Nature America, Inc. All rights reserved.Genome-wide DNA sequencing was used to decrypt the phylogeny of multiple samples from distinct areas of cancer and morphologically normal tissue taken from the prostates of three men. Mutations were pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5b47a3e9612f7d159660895d16db9b
https://www.repository.cam.ac.uk/handle/1810/267175