Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sue M Travis"'
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e43563 (2012)
Alterations in the ubiquitin-proteasome system (UPS) have been reported in several neurodegenerative disorders characterized by protein misfolding and aggregation, including the polylgutamine diseases. Machado-Joseph disease (MJD) or Spinocerebellar
Externí odkaz:
https://doaj.org/article/953a45f3f77a47878c368799e837f737
Publikováno v:
Current Opinion in Immunology. 13:89-95
Recent studies have advanced our understanding of innate immune mechanisms that protect the airways and maintain a sterile lung. Multiple antimicrobial peptides and proteins have been identified in airway secretions and their roles are beginning to b
Autor:
Jeffrey J. Smith, Joseph Zabner, Barbara Ann D. Conway, Michael J. Welsh, Pradeep K. Singh, E. Peter Greenberg, Norma N. Anderson, Sue M. Travis
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 20:872-879
Human airways produce several antimicrobial factors; the most abundant are lysozyme and lactoferrin. Despite their likely importance in preventing infection, and their possible key role in the pathogenesis of cystic fibrosis (CF), we know little abou
Publikováno v:
Europe PubMed Central
While studying the regulation of the cystic fibrosis transmembrane conductance regulator (CFTR), we found that addition of F−to the cytosolic surface of excised, inside-out membrane patches reversibly increased Cl−current in a dose-dependent mann
Publikováno v:
Proceedings of the National Academy of Sciences. 94:11055-11060
cAMP-dependent phosphorylation activates the cystic fibrosis transmembrane conductance regulator (CFTR) in epithelia. However, the protein phosphatase (PP) that dephosphorylates and inactivates CFTR in airway and intestinal epithelia, two major sites
Autor:
Sue M. Travis, Michael J. Welsh
Publikováno v:
FEBS Letters. 412:415-419
We have cloned a novel cDNA from human skeletal muscle which encodes a protein phosphatase with a unique acidic domain. It is 34% identical to mammalian PP2Cα and PP2Cβ, and we call it PP2Cγ. It more closely resembles PP2Cs from Paramecium tetraur
Publikováno v:
Journal of Biological Chemistry. 271:14995-15001
Proline residues located in membrane-spanning domains of transport proteins are thought to play an important structural role. In the cystic fibrosis transmembrane conductance regulator (CFTR), the predicted transmembrane segments contain four proline
Publikováno v:
Cell. 85:229-236
thelia causes chronic bacterial infections in cystic fi- al. (1989) have shown that airway surface fluid from brosis (CF) airways. Here, we show that common CF patients with CF has increased concentrations of Cl2 pathogens were killed when added to t
Publikováno v:
Journal of Biological Chemistry. 270:1711-1717
The cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel contains two cytoplasmic nucleotide-binding domains (NBDs). After phosphorylation of the R domain, ATP interacts with the NBDs to regulate channel activity. To learn how the N
Publikováno v:
Biophysical Journal. 67(5):1867-1875
Cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels appear to be regulated by hydrolysis of ATP and are inhibited by a product of hydrolysis, ADP. We assessed the effect of the other product of hydrolysis, inorganic phosphate (P(i