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Molecular Dynamics and Free Energy Calculations of the B and Z Forms of C8-Arylguanine Modified Oligonucleotides

Publikováno v: Journal of Biomolecular Structure and Dynamics. 23:203-219

Arylhydrazines found in the mushroom Agaricus bisporus have been shown to be carcinogenic. Upon metabolic activation, arylhydrazines are transformed into aryl radicals, forming 8-arylpurines, which may play a role in arylhydrazine carcinogenesis. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a49be31bb466dff237bd737c4678c8
https://doi.org/10.1080/07391102.2005.10507060

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Synthesis, properties, and NMR studies of a C8-phenylguanine modified oligonucleotide that preferentially adopts the Z DNA conformation

Autor: Jon D. Epperson, Peter M. Gannett, Kevin H. Shaughnessy, Sue Heavner, Jonathan R. Daft, Nancy L. Greenbaum

Publikováno v: Chemical research in toxicology. 16(10)

Carcinogenic aryl hydrazines produce C8-arylated purine adducts. The effect of these adducts on DNA conformation and their role in hydrazine carcinogenesis are unknown. Here, we describe a new synthetic route to produce these adducts that is also com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b72b9eb65d3998895b53765a66ecf2
https://pubmed.ncbi.nlm.nih.gov/14565779

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