Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Sue Haupt"'
Autor:
Javier Octavio Mejía-Hernández, Simon P. Keam, Reem Saleh, Fenella Muntz, Stephen B. Fox, David Byrne, Arielle Kogan, Lokman Pang, Jennifer Huynh, Cassandra Litchfield, Franco Caramia, Guillermina Lozano, Hua He, James M. You, Shahneen Sandhu, Scott G. Williams, Ygal Haupt, Sue Haupt
Publikováno v:
Cell Death and Disease, Vol 13, Iss 9, Pp 1-17 (2022)
Abstract Understanding prostate cancer onset and progression in order to rationally treat this disease has been critically limited by a dire lack of relevant pre-clinical animal models. We have generated a set of genetically engineered mice that mimi
Externí odkaz:
https://doaj.org/article/72de5aef0f664a85b0c01a44bc290580
Publikováno v:
Cells, Vol 12, Iss 18, p 2245 (2023)
Ubiquitous to normal female human somatic cells, X-chromosome inactivation (XCI) tightly regulates the transcriptional silencing of a single X chromosome from each pair. Some genes escape XCI, including crucial tumour suppressors. Cancer susceptibili
Externí odkaz:
https://doaj.org/article/a783c30d86904abfac32b7464c48a57f
Autor:
Scott G. Williams, Han Xian Aw Yeang, Catherine Mitchell, Franco Caramia, David J. Byrne, Stephen B. Fox, Sue Haupt, Ralf B. Schittenhelm, Paul J. Neeson, Ygal Haupt, Simon P. Keam
Publikováno v:
BMC Urology, Vol 20, Iss 1, Pp 1-16 (2020)
Abstract Background Understanding the drivers of recurrence in aggressive prostate cancer requires detailed molecular and genomic understanding in order to aid therapeutic interventions. We provide here a case report of histological, transcriptional,
Externí odkaz:
https://doaj.org/article/a172b3ccea2d4a5fbb134c26a9cf1088
Autor:
Neil Portman, Heloisa H. Milioli, Sarah Alexandrou, Rhiannon Coulson, Aliza Yong, Kristine J. Fernandez, Kee Ming Chia, Ensar Halilovic, Davendra Segara, Andrew Parker, Sue Haupt, Ygal Haupt, Wayne D. Tilley, Alex Swarbrick, C. Elizabeth Caldon, Elgene Lim
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-17 (2020)
Abstract Background Resistance to endocrine therapy is a major clinical challenge in the management of oestrogen receptor (ER)-positive breast cancer. In this setting, p53 is frequently wildtype and its activity may be suppressed via upregulation of
Externí odkaz:
https://doaj.org/article/b6f51a6926794f258d9ad544dc70f957
Autor:
Cristina Gamell, Ivona Bandilovska, Twishi Gulati, Arielle Kogan, Syer Choon Lim, Zaklina Kovacevic, Elena A. Takano, Clelia Timpone, Arjelle D. Agupitan, Cassandra Litchfield, Giovanni Blandino, Lisa G. Horvath, Stephen B. Fox, Scott G. Williams, Andrea Russo, Enzo Gallo, Piotr J. Paul, Catherine Mitchell, Shahneen Sandhu, Simon P. Keam, Sue Haupt, Des R. Richardson, Ygal Haupt
Publikováno v:
iScience, Vol 22, Iss , Pp 1-15 (2019)
Summary: Although primary prostate cancer is largely curable, progression to metastatic disease is associated with very poor prognosis. E6AP is an E3 ubiquitin ligase and a transcriptional co-factor involved in normal prostate development. E6AP drive
Externí odkaz:
https://doaj.org/article/b647e01078dd499387cf60597e19c626
Autor:
Sue Haupt, Franco Caramia, Alan Herschtal, Thierry Soussi, Guillermina Lozano, Hu Chen, Han Liang, Terence P. Speed, Ygal Haupt
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
There is disproportionally high cancer prevalence in males. Here, the authors analyse the tumour suppressor p53 in sporadic cancers, highlighting a higher incidence of its mutation in males. Males are further disadvantaged by a failure to shield agai
Externí odkaz:
https://doaj.org/article/1a749f75f57f428ea7b81ae7e79a67f1
Autor:
Sue Haupt, Ygal Haupt
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
There are many differences in cancer manifestation between men and women. New understanding of the origin of these point to fundamental distinctions in the genetic code and its demise. Tumour suppressor protein p53 is the chief operating officer of c
Externí odkaz:
https://doaj.org/article/c0b773ba71f641c89d99788de1d95eea
Autor:
Shahneen Sandhu, Heloise Halse, Minyu Wang, Catherine Mitchell, Franco Caramia, Sue Haupt, Georgina Ryland, Piers Blombery, Ygal Haupt, Simon Keam, ThuNgoc Nguyen, Nicolas Van Kooten Losio, David Byrne, Scott Williams
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/ef9605f1513e42f3af2c7159e3e517b6
Autor:
Shahneen Sandhu, Paul J Neeson, Simon P Keam, Heloise Halse, Thu Nguyen, Minyu Wang, Nicolas Van Kooten Losio, Catherine Mitchell, Franco Caramia, David J Byrne, Sue Haupt, Georgina Ryland, Phillip K Darcy, Piers Blombery, Ygal Haupt, Scott G Williams
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Prostate cancer (PCa) has a profoundly immunosuppressive microenvironment and is commonly immune excluded with few infiltrative lymphocytes and low levels of immune activation. High-dose radiation has been demonstrated to stimulate the imm
Externí odkaz:
https://doaj.org/article/80d24ee76e7f4079aca96e405ba2bd33
Autor:
Shashank Masaldan, Sharnel A.S. Clatworthy, Cristina Gamell, Peter M. Meggyesy, Antonia-Tonia Rigopoulos, Sue Haupt, Ygal Haupt, Delphine Denoyer, Paul A. Adlard, Ashley I. Bush, Michael A. Cater
Publikováno v:
Redox Biology, Vol 14, Iss , Pp 100-115 (2018)
Cellular senescence is characterised by the irreversible arrest of proliferation, a pro-inflammatory secretory phenotype and evasion of programmed cell death mechanisms. We report that senescence alters cellular iron acquisition and storage and also
Externí odkaz:
https://doaj.org/article/a96895613dbf49e89ee6e657f66f5180