Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Sue E Delos"'
Autor:
Charles J Shoemaker, Kathryn L Schornberg, Sue E Delos, Corinne Scully, Hassan Pajouhesh, Gene G Olinger, Lisa M Johansen, Judith M White
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56265 (2013)
Ebola virus (EBOV) is an enveloped RNA virus that causes hemorrhagic fever in humans and non-human primates. Infection requires internalization from the cell surface and trafficking to a late endocytic compartment, where viral fusion occurs, providin
Externí odkaz:
https://doaj.org/article/e41b76c3bdb5499fbd5498b5ccc2905a
Autor:
Charles J. Shoemaker, Kathryn L. Schornberg, Sue E. Delos, Corinne Scully, Hassan Pajouhesh, Gene G. Olinger, Lisa M. Johansen, Judith M. White
Publikováno v:
PLoS ONE, Vol 8, Iss 10 (2013)
Externí odkaz:
https://doaj.org/article/e9ff707137b94f6f833ef47273975822
Autor:
Sue E. Delos, Kathryn L. Schornberg, Erica Ollmann Saphire, Matthew Brecher, Marnie L. Fusco, Judith M. White
Publikováno v:
Journal of Virology
Cellular entry of Ebola virus (EBOV), a deadly hemorrhagic fever virus, is mediated by the viral glycoprotein (GP). The receptor-binding subunit of GP must be cleaved (by endosomal cathepsins) in order for entry and infection to proceed. Cleavage app
Publikováno v:
Proceedings of the National Academy of Sciences
Ebolavirus (Ebov), an enveloped virus of the family Filoviridae , causes hemorrhagic fever in humans and nonhuman primates. The viral glycoprotein (GP) is solely responsible for virus–host membrane fusion, but how it does so remains elusive. Fusion
Publikováno v:
Journal of Virology. 84:5687-5694
Most class I fusion proteins exist as trimers of dimers composed of a receptor binding and a fusion subunit. In their postfusion forms, the three fusion subunits form trimers of hairpins consisting of a central coiled coil (formed by the N-terminal h
Publikováno v:
Journal of Virology. 83:12139-12150
To study vesicular stomatitis virus (VSV) entry and uncoating, we generated a recombinant VSV encoding a matrix (M) protein containing a C-terminal tetracysteine Lumio tag (rVSV-ML) that could be fluorescently labeled using biarsenical compounds. Qua
Autor:
Judith M. White, Michelle Y. Abshire, Derek Dube, Amy H. Bouton, Charles J. Shoemaker, Sue E. Delos, Kathryn L. Schornberg
Publikováno v:
Proceedings of the National Academy of Sciences
Integrins are involved in the binding and internalization of both enveloped and nonenveloped viruses. By using 3 distinct cell systems—CHO cells lacking expression of α 5 β 1 -integrin, HeLa cells treated with siRNA to α 5 -integrin, and mouse
Autor:
Edward W. Park, Matthew Brecher, Sue E. Delos, Judith M. White, Jens H. Kuhn, Sean C. Rose, Kathryn L. Schornberg, Derek Dube
Publikováno v:
Journal of Virology. 83:2883-2891
Entry of ebolavirus (EBOV) into cells is mediated by its glycoprotein (GP 1,2 ), a class I fusion protein whose structure was recently determined (J. E. Lee et al., Nature 454: 177-182, 2008). Here we confirmed two major predictions of the structural
Autor:
Matthew I. Bonaparte, Tzanko S. Stantchev, Christopher C. Broder, Sue E. Delos, Judith M. White, Derek Dube, Amy H. Bouton, Kathryn L. Schornberg
Publikováno v:
Journal of Virology. 82:7238-7242
Ebola virus infects a wide variety of adherent cell types, while nonadherent cells are found to be refractory. To explore this correlation, we compared the ability of pairs of related adherent and nonadherent cells to bind a recombinant Ebola virus r
Autor:
Deborah C. Melder, Mark J. Federspiel, Sue E. Delos, Zaoying Chen, Matthew Brecher, Judith M. White
Publikováno v:
Journal of Virology. 82:3131-3134
We previously showed that the cysteines flanking the internal fusion peptide of the avian sarcoma/leukosis virus subtype A (ASLV-A) Env (EnvA) are important for infectivity and cell-cell fusion. Here we define the stage of fusion at which the cystein