Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sue D, Collins"'
Autor:
Andrew Charlton, Stephen J. Medhurst, Laura J. Chambers, Livermore David, Brian Peter Slingsby, Andy Billinton, Lee William Page, Anton D. Michel, Daryl S. Walter, Jon Graham Anthony Steadman, Shilina Roman, Sadhana Patel, Elena Fonfria, Robert Gleave, Stefan Senger, Katharine Laura Collis, Andrew P. Moses, Sue D. Collins, Muna H. Abdi, Paul John Beswick, Clarisse L. Lejeune, David Kenneth Dean, Alexander J. Stevens
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5080-5084
A computational lead-hopping exercise identified compound 4 as a structurally distinct P2X(7) receptor antagonist. Structure-activity relationships (SAR) of a series of pyroglutamic acid amide analogues of 4 were investigated and compound 31 was iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3ff37009bb76b9bfd50c27c623c06d
https://doi.org/10.1016/j.bmcl.2010.07.033
https://doi.org/10.1016/j.bmcl.2010.07.033
Publikováno v:
European Journal of Pain. 11:605-613
Immunohistochemistry was used to examine the expression of prostaglandin E(2) receptors EP1 and EP4 in sciatic nerves from the rat chronic constriction injury (CCI) model of neuropathic pain. At 21 days post-surgery the CCI rats had developed mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf0f04416cc0914bb10d165eb0ebe740
https://doi.org/10.1016/j.ejpain.2006.09.005
https://doi.org/10.1016/j.ejpain.2006.09.005
Autor:
Simon T. Bate, Sue D. Collins, Jo C Martindale, Caroline J Sharp, Scott G. Summerfield, Alison J Reeve, Iain P. Chessell, Becky Sargent
Publikováno v:
British Journal of Pharmacology. 148:845-852
1. Two P2X(3)/P2X(2/3) receptor antagonists with different potencies were profiled electrophysiologically in a rat model of nerve injury. 2. A-317491 has poor CNS penetrance (blood:brain, 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cbd553c9c6e5cab1bc19d1432d84513
https://doi.org/10.1038/sj.bjp.0706790
https://doi.org/10.1038/sj.bjp.0706790
Autor:
Iain P. Chessell, Sue D. Collins, Richard G. Knowles, Jorge De Alba, Philip Colthup, Nick M. Clayton
Publikováno v:
Pain. 120:170-181
Nitric oxide (NO), synthesised by different isoforms of nitric oxide synthase (NOS), has been linked with the development and maintenance of nociception. We studied the role of the inducible isoform, iNOS, in two different rat pain models with an inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44ac8c3477b3ddb9108f08b73e2d15c
https://doi.org/10.1016/j.pain.2005.10.028
https://doi.org/10.1016/j.pain.2005.10.028
Autor:
C. Bountra, M J Sheehan, David J. Spalding, Alan Naylor, Paul John Beswick, C.D. Eldred, Sue D. Collins, R.P.C. Cousins, Nick M. Clayton
Publikováno v:
Medicinal Chemistry Research. 13:88-98
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06d3174570f5ab5a7ae0fed599234b53
https://doi.org/10.1007/s00044-004-0013-y
https://doi.org/10.1007/s00044-004-0013-y
Autor:
Paul F. Lambeth, Fiona S. Lucas, Richard Howard Green, Martin E. Swarbrick, Jeremy John Payne, Lee William Page, Malcolm Clive Carter, Paul John Beswick, Alexander J. Stevens, Sharon C Stratton, Neil Anthony Pegg, John Skidmore, Savvas Kleanthous, Alastair J. Stuart, Sue D. Collins, Sharon Bingham, John Andrew Corfield, Richard Stocker, Joanne O. Wiseman, C. David Hartley, Helen Susanne Price, Neil Mathews, Laura J. Chambers, Iain P. Chessell, Robert Gleave, Nick M. Clayton, Alan Naylor, C. Bountra
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
A novel series of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidine-based cyclooxygenase-2 (COX-2) inhibitors, which have a different arrangement of substituents compared to the more common 1,2-diarylheterocycle based molecules, have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadff8d23a6fefccadd5166b5ed7fd16
https://pubmed.ncbi.nlm.nih.gov/19520573
https://pubmed.ncbi.nlm.nih.gov/19520573
Autor:
Sharon Bingham, Andrew D. Medhurst, Robert G. Dalziel, Iain P. Chessell, Stephen J. Medhurst, Andy Billinton, Jennifer C. Roberts, Amanda Brass, Sue D. Collins
Publikováno v:
PainReferences. 138(1)
Several studies have implicated a potential role for histamine H 3 receptors in pain processing, although the data are somewhat conflicting. In the present study we investigated the effects of the novel potent and highly selective H 3 receptor antago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50881dd25935ed7a1bcdab5cda639c75
https://pubmed.ncbi.nlm.nih.gov/18164820
https://pubmed.ncbi.nlm.nih.gov/18164820
Autor:
Caroline J, Sharp, Alison J, Reeve, Sue D, Collins, Jo C, Martindale, Scott G, Summerfield, Becky S, Sargent, Simon T, Bate, Iain P, Chessell
Publikováno v:
British journal of pharmacology. 148(6)
1. Two P2X(3)/P2X(2/3) receptor antagonists with different potencies were profiled electrophysiologically in a rat model of nerve injury. 2. A-317491 has poor CNS penetrance (blood:brain, 1:0.05), and was therefore administered intravenously in chron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d72ebccdbead63607d7bec3ffaff0a48
https://pubmed.ncbi.nlm.nih.gov/16770326
https://pubmed.ncbi.nlm.nih.gov/16770326
Autor:
Alex W. Wilson, Royston A. Gray, Pascal F. Durrenberger, Iain P. Chessell, Praveen Anand, Rolfe Birch, Sharon Bingham, Nicola C. Day, Paul Facer, Maria A Casula, Sue D. Collins, Yiangos Yiangou, David Elliot
Publikováno v:
BMC Neurology, Vol 6, Iss 1, p 1 (2006)
BMC Neurology
BMC Neurology
Background Recent studies show that inflammatory processes may contribute to neuropathic pain. Cyclooxygenase-2 (Cox-2) is an inducible enzyme responsible for production of prostanoids, which may sensitise sensory neurones via the EP1 receptor. We ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a90ee3b9cf6aebe5f880821628bb3b
http://www.biomedcentral.com/1471-2377/6/1
http://www.biomedcentral.com/1471-2377/6/1
Autor:
Meindert Danhof, Joost DeJongh, Adriaan P. IJzerman, Marloes P. Schaddelee, Albertus G. de Boer, Sue D. Collins
Publikováno v:
European journal of pharmacology. 514(2-3)
The objective of this investigation was to characterise the pharmacokinetic-pharmacodynamic correlation of adenosine A1 receptor partial agonists in the chronic constriction injury model of neuropathic pain. Following intravenous administration of 8-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb43695aa996fd0cef5a719116f1104
https://pubmed.ncbi.nlm.nih.gov/15910799
https://pubmed.ncbi.nlm.nih.gov/15910799