Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sue Cramp"'
Autor:
Kurumi Y. Horiuchi, Roslin Adamson, Ahmed Aman, Ahmed Mamai, Soyoung Kim, Haiching Ma, Sue Cramp, Taira Kiyota, Alex N. Bullock, David Uehling, Jeff A O'Meara, Eleanor Williams, Methvin Isaac, J Nicole Hamblin, Ekaterina Kuznetsova, Julie Owen, David McLeod, Jong Fu Wong, Gennady Poda, David Smil, Owen G Roberts, Aled M. Edwards, Alison Howarth, Brian J. Wilson, Rima Al-awar
There are currently no effective chemotherapeutic drugs approved for the treatment of diffuse intrinsic pontine glioma (DIPG), an aggressive pediatric cancer resident in the pons region of the brainstem. Radiation therapy is beneficial but not curati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dafcc5d75dab7a89554a419605d3d343
https://ora.ox.ac.uk/objects/uuid:4cce623b-5222-4aab-8937-7fb64280705f
https://ora.ox.ac.uk/objects/uuid:4cce623b-5222-4aab-8937-7fb64280705f
Autor:
Sue Cramp, Nicole Hamblin, Jeff O'Meara, Aled Edwards, Owen Roberts, Alex Bullock, Paul Brennan
Publikováno v:
Cancer Research. 79:4457-4457
Meds4Kids Pharma (M4K)1 is pioneering an open science approach to drug discovery, focussed on the discovery and development of small molecule therapeutics for orphan paediatric cancers. M4K seeks to test the hypothesis that an open science framework
Autor:
Gill Matthew Iain Andrew, Nigel Ramsden, Steve Price, Christopher Higgs, Richard Hale, Dennis Norman, Dan Leggate, Hazel Joan Dyke, Soraya S. Porres, Raffaella Mangano, Pascal Savy, Alison Jones, Francis Xavier Wilson, Peter Lockey, Neil Jennings, David E. Clark, Sue Cramp, Marie Andersson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2516-2519
The identification and hit-to-lead exploration of a novel, potent and selective series of histamine H4 receptor inverse agonists is described. The initial hit, 3A (IC50 19 nM) was identified by means of a ligand-based virtual screening approach. Subs
Autor:
Alan Geoffrey Roach, Dennis Norman, Melanie Wong, Hazel Joan Dyke, Sue Cramp, Stephen Paul Wren, Rosa Arienzo, Peter Lockey, Phil Smith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1403-1407
We have modified the previously reported 2-aminoquinoline 1 to provide two novel series of MCH-1R antagonists. Representative compounds from the quinazoline and benzimidazole series have been shown to be potent and selective, with promising in vitro
Autor:
Keith A. J. Stuttle, Peter Lockey, Dennis Norman, Melanie Wong, David E. Clark, Alan Geoffrey Roach, Hazel Joan Dyke, Stephen Daly, Stephen Paul Wren, Sue Cramp, Rosa Arienzo, Maxine Tomlinson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4099-4102
A new series of 2-aminoquinolines has been identified as antagonists of the melanin concentrating hormone receptor (MCH-1R). Syntheses and structure-activity relationships are described leading to a compound having low nanomolar activity against the
Autor:
Sue Cramp
Publikováno v:
Preparing to Teach: Learning from experience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7be204a8cff1a123c0ca9a171bbae28b
https://doi.org/10.4324/9780203464014_chapter_4
https://doi.org/10.4324/9780203464014_chapter_4
Autor:
Sue Cramp, Marco Van Den Heuvel, Iwan J. P. de Esch, Steve Price, Sophie Gardan, Richard Bull, Susan E. Osbourn, David Neighbour, Christoph L. Buenemann
Publikováno v:
ChemInform. 35
A library of 2-guanidinomethyl-4(5)-sulfamoylimidazoles was synthesised in a convergent manner by introducing a sulfonyl chloride group via a trianion electrophilic sulfinylation of suitably protected 2-guanidinomethyl imidazoles.