Výsledky vyhledávání - "Sue A. Shelley"

Inhibition of JNK by cellular stress- and tumor necrosis factor α-induced AKT2 through activation of the NFκB pathway in human epithelial cells

Autor: Nancy Olashaw, Richard I. Feldman, Jin Q. Cheng, Mei Sun, Zeng-qiang Yuan, Sue A. Shelley, Domenico Coppola, Santo V. Nicosia, Gene E. Sussman

Publikováno v: The Journal of biological chemistry. 291(43)

Previous studies have demonstrated that AKT1 and AKT3 are activated by heat shock and oxidative stress via both phosphatidylinositol 3-kinase-dependent and -independent pathways. However, the activation and role of AKT2 in the stress response have no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8860331c7790fa259dc3a5937ca12417
https://pubmed.ncbi.nlm.nih.gov/12048203

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AKT1/PKBα Kinase Is Frequently Elevated in Human Cancers and Its Constitutive Activation Is Required for Oncogenic Transformation in NIH3T3 Cells

Autor: Richard I. Feldman, Sue A. Shelley, Zeng-qiang Yuan, Xiao-ling Ma, Richard Jove, Santo V. Nicosia, Mei Sun, June E. Paciga, Jin Q. Cheng, Philip N. Tsichlis, Gen Wang

Publikováno v: The American Journal of Pathology. 159:431-437

Extensive studies have demonstrated that the Akt/AKT1 pathway is essential for cell survival and inhibition of apoptosis; however, alterations of Akt/AKT1 in human primary tumors have not been well documented. In this report, significantly increased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720f1d845130dd6161c922bcde0cbd3f
https://doi.org/10.1016/s0002-9440(10)61714-2

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Positive feedback regulation between Akt2 and MyoD during muscle differentiation. CLONING OF Akt2 PROMOTER

Autor: Satoshi Kaneko, Jinquan Cheng, Zhenguo Wu, Richard I. Feldman, Tatiana M. Gritsko, Sue A. Shelley, Lu Yu, Tsutomu Nobori, Santo V. Nicosia

Publikováno v: Journal of Biological Chemistry. 291:22850

Akt2 is a member of the Akt/PKB family, which is involved in a variety of cellular events including cell survival, proliferation, and differentiation. During skeletal muscle differentiation, the Akt2 but not Akt1 expression was significantly increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973ff18f4f1cb8f30425b5a80c930b0b
https://doi.org/10.1074/jbc.a116.201733

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DEPLETION OF SURFACTANT TUBULAR MYELIN WITH PULMONARY DYSFUNCTION IN A RAT MODEL FOR ACUTE ENDOTOXEMIA

Autor: Sue A. Shelley, John U. Balis, Edward M Haller, James F. Paterson, Alex Castiello

Publikováno v: Shock. 2:427-432

Although prolonged Gram-negative sepsis with high permeability alveolar edema, a well documented cause of adult respiratory distress syndrome, has been shown to result in surfactant alterations, the effects of acute endotoxemia on the lung surfactant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee3917215111cf13128e09e5a1be6db
https://doi.org/10.1097/00024382-199412000-00007

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Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer

Autor: Tatiana M, Gritsko, Domenico, Coppola, June E, Paciga, Lin, Yang, Mei, Sun, Sue A, Shelley, James V, Fiorica, Santo V, Nicosia, Jin Q, Cheng

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 9(4)

Previous studies have demonstrated amplification of the centrosome serine/threonine kinase BTAK/Aurora-A in 10-25% of ovarian cancers. However, alterations of BTAK/Aurora-A at kinase and protein levels and its role in ovarian cancer progression have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b9a98473fa526266cbc4340feaedb20
https://pubmed.ncbi.nlm.nih.gov/12684414

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NR8383 alveolar macrophage toxic growth arrest by hydrogen peroxide is associated with induction of growth-arrest and DNA damage-inducible genes GADD45 and GADD153

Autor: Geoffrey W. Patton, Sue A. Shelley, June E. Paciga

Publikováno v: Toxicology and applied pharmacology. 147(1)

Breathing air exposes humans and other mammals to various toxic agents including oxidative contaminants associated with fine particles of less than 2.5 micron which may be deposited in the deep lung and have been implicated in the increased morbidity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f711dd060d2d3c6dbd4489cb947719a3
https://pubmed.ncbi.nlm.nih.gov/9356315

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Detection of hydroxyl radicals upon interaction of ozone with aqueous media or extracellular surfactant: the role of trace iron

Autor: Michael J. Barber, Mark R. Montgomery, John U. Balis, Sue A. Shelley, Paul Byvoet

Publikováno v: Archives of biochemistry and biophysics. 319(2)

As part of a study on mechanisms modulating ozone-induced surfactant perturbations, we used the electron paramagnetic resonance (EPR) spin trapping technique to determine the type and origin of radicals generated following interaction of ozone with a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7265103cc5fef17ba3778196a6bb7022
https://pubmed.ncbi.nlm.nih.gov/7786029

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Immunocytochemical localization of lysozyme and surfactant protein A in rat type II cells and extracellular surfactant forms

Autor: John U. Balis, Edward M Haller, Mark R. Montgomery, Sue A. Shelley

Publikováno v: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 40(10)

Using immunogold labeling of fixed, cryosubstituted tissue sections, we compared the distribution of lysozyme, an oxidant-sensitive lamellar body protein, with that of surfactant protein A (SP-A) in rat Type II cells, extracellular surfactant forms,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7fe1766609313233c05bf1572920d2
https://pubmed.ncbi.nlm.nih.gov/1527372

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Lysozyme is an ozone-sensitive component of alveolar type II cell lamellar bodies

Autor: John U. Balis, June E. Paciga, Sue A. Shelley

Publikováno v: Biochimica et biophysica acta. 1096(4)

Exposure of rats to 3 ppm ozone for up to 8 h results in significant changes in lamellar bodies, the surfactant storing organelles of type II cells. We have previously shown that a 14 kDa lamellar body protein is decreased as early as 4 h after the o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5958c7a3c8548efa45ff332bbfaadb05
https://pubmed.ncbi.nlm.nih.gov/2065105

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