Zobrazeno 1 - 10
of 298
pro vyhledávání: '"Sudipto, Das"'
Autor:
Xiuxiu Lu, Monika Chandravanshi, Venkata R. Sabbasani, Snehal Gaikwad, V. Keith Hughitt, Nana Gyabaah-Kessie, Bradley T. Scroggins, Sudipto Das, Wazo Myint, Michelle E. Clapp, Charles D. Schwieters, Marzena A. Dyba, Derek L. Bolhuis, Janusz W. Koscielniak, Thorkell Andresson, Michael J. Emanuele, Nicholas G. Brown, Hiroshi Matsuo, Raj Chari, Deborah E. Citrin, Beverly A. Mock, Rolf E. Swenson, Kylie J. Walters
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Proteasome subunit hRpn13 is partially proteolyzed in certain cancer cell types to generate hRpn13Pru by degradation of its UCHL5/Uch37-binding DEUBAD domain and retention of an intact proteasome- and ubiquitin-binding Pru domain. By using s
Externí odkaz:
https://doaj.org/article/287afc8f95ca4e0dbcecccb50eebdb48
Autor:
Nicola Cosgrove, Alex J. Eustace, Peter O’Donovan, Stephen F. Madden, Bruce Moran, John Crown, Brian Moulton, Patrick G. Morris, Liam Grogan, Oscar Breathnach, Colm Power, Michael Allen, Janice M. Walshe, Arnold D. Hill, Anna Blümel, Darren O’Connor, Sudipto Das, Małgorzata Milewska, Joanna Fay, Elaine Kay, Sinead Toomey, Bryan T. Hennessy, Simon J. Furney
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-16 (2023)
Abstract HER2-positive (HER2+) breast cancer accounts for 20–25% of all breast cancers. Predictive biomarkers of neoadjuvant therapy response are needed to better identify patients with early stage disease who may benefit from tailored treatments i
Externí odkaz:
https://doaj.org/article/2aa94f4a6ce8446ea48464a6049912d0
Autor:
Xu Zhang, Sudipto Das, Zhiya Yu, Ken-ichi Hanada, James C Yang, Thorkell Andresson, Catherine M Ade, Matthew J Sporn, Yue A Qi, Tapan Maity, Udayan Guha
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 9 (2023)
Background Tumor-specific mutated proteins can create immunogenic non-self, mutation-containing ‘neoepitopes’ that are attractive targets for adoptive T-cell therapies. To avoid the complexity of defining patient-specific, private neoepitopes, th
Externí odkaz:
https://doaj.org/article/58a08e7c3c1e4ebdb8cc548abf290a85
Autor:
Ian S. Miller, Sonja Khan, Liam P. Shiels, Sudipto Das, Alice C. O' Farrell, Kate Connor, Adam Lafferty, Bruce Moran, Claudio Isella, Paul Loadman, Emer Conroy, Susan Cohrs, Roger Schibli, Robert S. Kerbel, William M. Gallagher, Elisabetta Marangoni, Kathleen Bennett, Darran P. O' Connor, Róisín M. Dwyer, Annette T. Byrne
Publikováno v:
Cancer Medicine, Vol 11, Iss 20, Pp 3820-3836 (2022)
Abstract Backgorund Prior data suggest pre‐diagnostic aspirin use impacts breast tumour biology and patient outcome. Here, we employed faithful surgical resection models of HER2+ and triple‐negative breast cancer (TNBC), to study outcome and resp
Externí odkaz:
https://doaj.org/article/1f5177ae512441ffab056e955c214925
Autor:
Nupur Nigam, Benjamin Bernard, Samantha Sevilla, Sohyoung Kim, Mohd Saleem Dar, Daniel Tsai, Yvette Robbins, Kyunghee Burkitt, Cem Sievers, Clint T. Allen, Richard L. Bennett, Theophilus T. Tettey, Benjamin Carter, Lorenzo Rinaldi, Mark W. Lingen, Houssein Sater, Elijah F. Edmondson, Arfa Moshiri, Abbas Saeed, Hui Cheng, Xiaolin Luo, Kevin Brennan, Vishal Koparde, Chen Chen, Sudipto Das, Thorkell Andresson, Abdalla Abdelmaksoud, Madhavi Murali, Seiji Sakata, Kengo Takeuchi, Raj Chari, Yusuke Nakamura, Ravindra Uppaluri, John B. Sunwoo, Carter Van Waes, Jonathan D. Licht, Gordon L. Hager, Vassiliki Saloura
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112823- (2023)
Summary: Cancers often display immune escape, but the mechanisms are incompletely understood. Herein, we identify SMYD3 as a mediator of immune escape in human papilloma virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC), an aggressiv
Externí odkaz:
https://doaj.org/article/b0940346e8a34a0c84bdf4ba79034b75
Autor:
Parvathi A. Myer, Hyunjin Kim, Anna M. Blümel, Ellen Finnegan, Alexander Kel, Taylor V. Thompson, John M. Greally, Jochen HM. Prehn, Darran P. O’Connor, Richard A. Friedman, Aris Floratos, Sudipto Das
Publikováno v:
Gastro Hep Advances, Vol 1, Iss 3, Pp 328-341 (2022)
Background and Aims: Individuals of African (AFR) ancestry have a higher incidence of colorectal cancer (CRC) than those of European (EUR) ancestry and exhibit significant health disparities. Previous studies have noted differences in the tumor micro
Externí odkaz:
https://doaj.org/article/18a7ea9fffb34eac8439f8f87e7ef340
Autor:
Xiuxiu Lu, Venkata R. Sabbasani, Vasty Osei-Amponsa, Christine N. Evans, Julianna C. King, Sergey G. Tarasov, Marzena Dyba, Sudipto Das, King C. Chan, Charles D. Schwieters, Sulbha Choudhari, Caroline Fromont, Yongmei Zhao, Bao Tran, Xiang Chen, Hiroshi Matsuo, Thorkell Andresson, Raj Chari, Rolf E. Swenson, Nadya I. Tarasova, Kylie J. Walters
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Rpn13 is a substrate receptor of the 26S proteasome and an anti-cancer drug target. Here, the authors identify and characterize XL5, a lead compound that binds to the N-terminal Pru domain of human Rpn13 (hRpn13), solve the NMR structure of XL5-ligat
Externí odkaz:
https://doaj.org/article/08204c7dee354ca7ab5e0c3b7e0c28d6
Autor:
Dominik Laubscher, Berkley E. Gryder, Benjamin D. Sunkel, Thorkell Andresson, Marco Wachtel, Sudipto Das, Bernd Roschitzki, Witold Wolski, Xiaoli S. Wu, Hsien-Chao Chou, Young K. Song, Chaoyu Wang, Jun S. Wei, Meng Wang, Xinyu Wen, Quy Ai Ngo, Joana G. Marques, Christopher R. Vakoc, Beat W. Schäfer, Benjamin Z. Stanton, Javed Khan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Rhabdomyosarcoma (RMS) is a pediatric malignancy of skeletal muscle lineage with an aggressive subtype caused by translocations involving PAX3- /PAX7-FOXO1 chimeric transcription factors. Here the authors show that the BRG1-containing BAF complex is
Externí odkaz:
https://doaj.org/article/3a3e0d79c30a410f82f8195b27c0b538
Autor:
Adrian Lita, Artem Pliss, Andrey Kuzmin, Tomohiro Yamasaki, Lumin Zhang, Tyrone Dowdy, Christina Burks, Natalia de Val, Orieta Celiku, Victor Ruiz-Rodado, Elena-Raluca Nicoli, Michael Kruhlak, Thorkell Andresson, Sudipto Das, Chunzhang Yang, Rebecca Schmitt, Christel Herold-Mende, Mark R. Gilbert, Paras N. Prasad, Mioara Larion
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The understanding of altered lipid metabolism by isocitrate dehydrogenase 1 (IDH1) mutations in gliomas at a compartment-specific level is limited. Here, the authors use Raman spectroscopy to monitor organelle-specific metabolic changes and report th
Externí odkaz:
https://doaj.org/article/1908125b7bca48998003ff46dab75493
Autor:
Master Chisale, Chris Watson, Joe Gallagher, Nadezhda Glezeva, Sudipto Das, Richard J Drew, Dermot Michael Wildes, Cillian De Gascun, Tsung-Shu Joseph Wu, Mark T Ledwidge
Publikováno v:
BMJ Open, Vol 11, Iss 7 (2021)
Objective To determine the aetiology of community acquired pneumonia in children presenting to primary care in Northern Malawi, and to ascertain predictors for identification of children requiring hospitalisation.Design The BIOmarkers TO diagnose PnE
Externí odkaz:
https://doaj.org/article/754d878c5945492fa8d28d580c96b7f9