Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sudipa Ghimire-Rijal"'
Autor:
Ryan P. Wurz, Huan Rui, Ken Dellamaggiore, Sudipa Ghimire-Rijal, Kaylee Choi, Kate Smither, Albert Amegadzie, Ning Chen, Xiaofen Li, Abhisek Banerjee, Qing Chen, Dane Mohl, Amit Vaish
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Targeted protein degradation via “hijacking” of the ubiquitin-proteasome system using proteolysis targeting chimeras (PROTACs) has evolved into a novel therapeutic modality. The design of PROTACs is challenging; multiple steps involved i
Externí odkaz:
https://doaj.org/article/de7e722d28104330ab18533bf9830472
Autor:
Marissa Mock, Alex W. Jacobitz, Christopher James Langmead, Athena Sudom, Daniel Yoo, Sara C. Humphreys, Mai Alday, Larysa Alekseychyk, Nicolas Angell, Vivian Bi, Hannah Catterall, Chen-Chun Chen, Hui-Ting Chou, Kip P. Conner, Kevin D. Cook, Ana R. Correia, Andrew Dykstra, Sudipa Ghimire-Rijal, Kevin Graham, Peter Grandsard, Joon Huh, John O. Hui, Mani Jain, Victoria Jann, Lei Jia, Sheree Johnstone, Neelam Khanal, Carl Kolvenbach, Linda Narhi, Rupa Padaki, Emma M. Pelegri-O’Day, Wei Qi, Vladimir Razinkov, Austin J. Rice, Richard Smith, Christopher Spahr, Jennitte Stevens, Yax Sun, Veena A. Thomas, Sarah van Driesche, Robert Vernon, Victoria Wagner, Kenneth W. Walker, Yangjie Wei, Dwight Winters, Melissa Yang, Iain D. G. Campuzano
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTBiologic drug discovery pipelines are designed to deliver protein therapeutics that have exquisite functional potency and selectivity while also manifesting biophysical characteristics suitable for manufacturing, storage, and convenient admin
Externí odkaz:
https://doaj.org/article/c7e86c82a6684b888888da7d561e8891
Autor:
Yonghong Bai, Xinchao Yu, Hao Chen, Daniel Horne, Ryan White, Xiaosu Wu, Paul Lee, Yan Gu, Sudipa Ghimire-Rijal, Daniel C-H Lin, Xin Huang
Publikováno v:
eLife, Vol 9 (2020)
Transient receptor potential canonical (TRPC) proteins form nonselective cation channels that play physiological roles in a wide variety of cells. Despite growing evidence supporting the therapeutic potential of TRPC6 inhibition in treating pathologi
Externí odkaz:
https://doaj.org/article/b71d3676556f4790a50a9b6e9f6e309e
Autor:
Brian Belmontes, Jodi Moriguchi, Grace Chung, Jan Sun, Maria Stefania S. Ninniri, Kelly Hanestad, Kui Chen, John D. McCarter, Upendra P. Dahal, Sudipa Ghimire-Rijal, Yue Hao, Christopher P. Mohr, Xinchao Yu, Matthew G. Rees, Melissa Ronan, Jennifer Roth, Sheroy Minocherhomji, Jennifer R. Allen, Matthew P. Bourbeau, Paul E. Hughes, Nuria A Tamayo, Marc N. Payton
Publikováno v:
Cancer Research. 83:516-516
Chromosomal instability (CIN) is a hallmark of human cancers and is caused by persistent errors in chromosome segregation during mitosis. Aggressive types of human cancer such as high-grade serous ovarian cancer and triple-negative breast cancer have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f35caf28e90cc86d95a85ee0af8c0a54
https://doi.org/10.1158/1538-7445.am2023-516
https://doi.org/10.1158/1538-7445.am2023-516
Autor:
Yan Gu, Daniel C-H Lin, Paul H. Lee, Ryan White, Xiaosu Wu, Daniel B. Horne, Yonghong Bai, Xinchao Yu, Hao Chen, Sudipa Ghimire-Rijal, Xin Huang
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Transient receptor potential canonical (TRPC) proteins form nonselective cation channels that play physiological roles in a wide variety of cells. Despite growing evidence supporting the therapeutic potential of TRPC6 inhibition in treating pathologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5cea2718121b864c5ca48f8ee2ded6a
http://europepmc.org/articles/PMC7082128
http://europepmc.org/articles/PMC7082128
Autor:
Le Li, Sarah L Lucas, Edward Wright, Dean A. A. Myles, Sudipa Ghimire-Rijal, Christopher B. Stanley, Matthew J. Cuneo, Pratul K. Agarwal
Publikováno v:
Biochemistry. 56:5328-5337
The ligand-induced conformational changes of periplasmic binding proteins (PBP) play a key role in the acquisition of metabolites in ATP binding cassette (ABC) transport systems. This conformational change allows for differential recognition of the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c429bb0c6bb1a6a4347be53f19c5e2d7
https://doi.org/10.1021/acs.biochem.7b00657
https://doi.org/10.1021/acs.biochem.7b00657
Publikováno v:
Current Opinion in Chemical Biology. 15:312-318
Protein controlled iron homeostasis is essential for maintaining appropriate levels and availability of metal within cells. Recently, two iron chaperones have been discovered that direct metal within two unique pathways: (1) mitochondrial iron-sulfur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b1d4fc9357e0d07bc161ce03a45eda
https://doi.org/10.1016/j.cbpa.2011.01.003
https://doi.org/10.1016/j.cbpa.2011.01.003
Publikováno v:
The Journal of biological chemistry. 289(43)
Many bacteria exist in a state of feast or famine where high nutrient availability leads to periods of growth followed by nutrient scarcity and growth stagnation. To adapt to the constantly changing nutrient flux, metabolite acquisition systems must
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3e9e8be6433ceaa75a7eba682148f2
https://pubmed.ncbi.nlm.nih.gov/25210043
https://pubmed.ncbi.nlm.nih.gov/25210043
Autor:
Parthapratim Munshi, Matthew J. Cuneo, Christopher B. Stanley, Sudipa Ghimire-Rijal, Dean A. A. Myles, Xun Lu
Publikováno v:
BMC Structural Biology
Background Members of the periplasmic binding protein (PBP) superfamily utilize a highly conserved inter-domain ligand binding site that adapts to specifically bind a chemically diverse range of ligands. This paradigm of PBP ligand binding specificit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c8788a967e01bd782c6b9e7becdfbd
https://doi.org/10.1186/1472-6807-13-18
https://doi.org/10.1186/1472-6807-13-18
Autor:
Poorna Subramanian, Timothy L. Stemmler, Richard K. Bruick, Anjali Nandal, Sudipa Ghimire-Rijal, Caroline C. Philpott, Julio C. Ruiz, Ruth Ann Sinnamon
Publikováno v:
Cell metabolism. 14(5)
SummaryMammalian cells express dozens of iron-containing proteins, yet little is known about the mechanism of metal ligand incorporation. Human poly (rC) binding protein 1 (PCBP1) is an iron chaperone that binds iron and delivers it to ferritin, a cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a396fafc0ea7cc6cf568cb6a2c3357
https://pubmed.ncbi.nlm.nih.gov/22055506
https://pubmed.ncbi.nlm.nih.gov/22055506