Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Sudhir Raghavan"'
Autor:
Federica Pisaneschi, Yu-Hsi Lin, Paul G. Leonard, Nikunj Satani, Victoria C. Yan, Naima Hammoudi, Sudhir Raghavan, Todd M. Link, Dimitra K. Georgiou, Barbara Czako, Florian L. Muller
Publikováno v:
Molecules, Vol 24, Iss 13, p 2510 (2019)
We recently reported that SF2312 ((1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid), a phosphonate antibiotic with a previously unknown mode of action, is a potent inhibitor of the glycolytic enzyme, Enolase. SF2312 can only be synthesized as a ra
Externí odkaz:
https://doaj.org/article/e2e793ae82144bf6a2f77eea61824b34
Autor:
Nikunj Satani, Yu-Hsi Lin, Naima Hammoudi, Sudhir Raghavan, Dimitra K Georgiou, Florian L Muller
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168739 (2016)
Inhibition of glycolysis is of great potential for the treatment of cancer. However, inhibitors of glycolytic enzymes with favorable pharmacological profiles have not been forthcoming. Due to the nature of their active sites, most high-affinity trans
Externí odkaz:
https://doaj.org/article/fd28d2bb750f405f8bbc77f0935a40fa
Autor:
Victoria C. Yan, Cong-Dat Pham, Elliot S. Ballato, Kristine L. Yang, Kenisha Arthur, Sunada Khadka, Yasaman Barekatain, Prakriti Shrestha, Theresa Tran, Anton H. Poral, Mykia Washington, Sudhir Raghavan, Barbara Czako, Federica Pisaneschi, Yu-Hsi Lin, Nikunj Satani, Naima Hammoudi, Jeffrey J. Ackroyd, Dimitra K. Georgiou, Steven W. Millward, Florian L. Muller
Publikováno v:
Journal of Medicinal Chemistry. 65:13813-13832
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c565c90ba8203219ba3e0da6dae7456
https://doi.org/10.1021/acs.jmedchem.2c01039
https://doi.org/10.1021/acs.jmedchem.2c01039
We have previously reported the in vitro and in vivo efficacy of N,N-bis(2-chloroethyl)-2-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)propenamide (MP-MUS), a prodrug that targeted the mitochondria of glioblastoma (GBM). The mitochondrial enzyme, monoami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b6d6a7a4b1262276688639c7700c21
https://doi.org/10.1158/1535-7163.c.6543111
https://doi.org/10.1158/1535-7163.c.6543111
Publikováno v:
Neurosurgery. 69:95-96
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdf07bc230b1ecb1cbeda5ba593155e4
https://doi.org/10.1227/neu.0000000000002375_460
https://doi.org/10.1227/neu.0000000000002375_460
Autor:
Victoria C. Yan, Cong-Dat Pham, Elliot S. Ballato, Kristine L. Yang, Sunada Khadka, Yasaman Barektain, Prakriti Shrestha, Theresa Tran, Anton H. Poral, Mykia Washington, Sudhir Raghavan, Barbara Czako, Federica Pisaneschi, Yu-Hsi Lin, Nikunj Satani, Naima Hammoudi, Jeffrey J. Ackroyd, Dimitra K. Georgiou, Steven W. Millward, Florian L. Muller
Publikováno v:
Cancer Research. 83:3097-3097
Cancers harboring homozygous deletion of the glycolytic enzyme enolase 1 (ENO1) are selectively vulnerable to inhibition of the paralogous isoform, enolase 2 (ENO2). We previously identified and characterized a competitive, small molecule phosphonate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a76ebf1b8e0029263b0896f4bcfec6a5
https://doi.org/10.1158/1538-7445.am2023-3097
https://doi.org/10.1158/1538-7445.am2023-3097
Publikováno v:
Neuro-Oncology. 24:vii100-vii101
Diffuse intrinsic pontine glioma (DIPG) is a universally fatal childhood cancer of the brain with 5-year survival rates of < 2%. Despite the introduction of conventional chemotherapy and radiotherapy, improvements in survival have been marginal and l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebe0ef59acc2cbf0c33a7b33ce71dfac
https://doi.org/10.1093/neuonc/noac209.376
https://doi.org/10.1093/neuonc/noac209.376
Publikováno v:
Encyclopedia of Biological Chemistry III ISBN: 9780128220405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cf275dff1da7d6f7892e777e3aa49fc
https://doi.org/10.1016/b978-0-12-819460-7.00343-1
https://doi.org/10.1016/b978-0-12-819460-7.00343-1
Publikováno v:
Oncotarget
Via extensive analyses of genetic databases, we have characterized the DNA-repair capacity of glioblastoma with respect to patient survival. In addition to elevation of O6-methylguanine DNA methyltransferase (MGMT), down-regulation of three DNA repai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf7e68ed65718fb224f6bf3b934a1cb
https://doi.org/10.18632/oncotarget.25246
https://doi.org/10.18632/oncotarget.25246
Publikováno v:
Neuro-Oncology. 23:vi78-vi78
BACKGROUND We have recently shown that GBM use D-galactose (Gal) as a substrate, in vitro and in vivo. Gal is imported via Glut3 and/or Glut14 and metabolized through the Leloir pathway. We investigated 4-deoxy-4-fluorogalactose (4DFG) as the lead co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55da5e3c6d23ad549d371040c8d04fff
https://doi.org/10.1093/neuonc/noab196.301
https://doi.org/10.1093/neuonc/noab196.301