Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sudhir P. Deosarkar"'
Autor:
Dharaminder Singh, Sudhir P Deosarkar, Elaine Cadogan, Vikki Flemington, Alysha Bray, Jingwen Zhang, Ronald S Reiserer, David K Schaffer, Gregory B Gerken, Clayton M Britt, Erik M Werner, Francis D Gibbons, Tomasz Kostrzewski, Christopher E Chambers, Emma J Davies, Antonio Ramos Montoya, Jacqueline H L Fok, David Hughes, Kristin Fabre, Matthew P Wagoner, John P Wikswo, Clay W Scott
Publikováno v:
PLoS Biology, Vol 20, Iss 5, p e3001624 (2022)
Test compounds used on in vitro model systems are conventionally delivered to cell culture wells as fixed concentration bolus doses; however, this poorly replicates the pharmacokinetic (PK) concentration changes seen in vivo and reduces the predictiv
Externí odkaz:
https://doaj.org/article/55008e3ff350462b806cde78444e0ef3
Autor:
Sudhir P Deosarkar, Balabhaskar Prabhakarpandian, Bin Wang, Joel B Sheffield, Barbara Krynska, Mohammad F Kiani
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142725 (2015)
Studies of neonatal neural pathologies and development of appropriate therapeutics are hampered by a lack of relevant in vitro models of neonatal blood-brain barrier (BBB). To establish such a model, we have developed a novel blood-brain barrier on a
Externí odkaz:
https://doaj.org/article/1576842059894909bb1e15dc22952f10
Autor:
Frank L. Schwartz, Monica M. Burdick, Mahboubeh S. Noori, Zachary J. Champa, Kelly D. McCall, Douglas J. Goetz, Chunyan Qi, Sudhir P. Deosarkar, John D. O'Brien, Stephen C. Bergmeier, Olivia L. Lanier
Publikováno v:
European Journal of Pharmacology. 803:130-137
Inhibition of interleukin–6 (IL-6) holds significant promise as a therapeutic approach for triple negative breast cancer (TNBC). We previously reported that phenylmethimazole (C10) reduces IL-6 expression in several cancer cell lines. We have ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d94dfae1b3cdef3a16677d5b100adb
https://doi.org/10.1016/j.ejphar.2017.03.049
https://doi.org/10.1016/j.ejphar.2017.03.049
Autor:
Kelly D. McCall, Mahboubeh S. Noori, Crina M. Orac, Mark C. McMills, Chaz M. Cuckler, Douglas J. Goetz, Davoud Ghazanfari, Maria C. Courreges, Stephen C. Bergmeier, Pooja Bhatt, Sudhir P. Deosarkar, Frank L. Schwartz
Publikováno v:
Am J Physiol Cell Physiol
Glycogen synthase kinase-3 (GSK-3) is a multitasking protein kinase that regulates numerous critical cellular functions. Not surprisingly, elevated GSK-3 activity has been implicated in a host of diseases including pathological inflammation, diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e29daaf893a4d9735b603a248ac5e99
https://pubmed.ncbi.nlm.nih.gov/31553649
https://pubmed.ncbi.nlm.nih.gov/31553649
Autor:
Sudhir P. Deosarkar, Devon J. King, Yuan Tang, Fariborz Soroush, Mohammad F. Kiani, Balabhaskar Prabhakarpandian, Laurie E. Kilpatrick, Ting Zhang
Publikováno v:
Journal of Leukocyte Biology. 100:1027-1035
A key step in neutrophil-mediated tissue damage is the migration of activated neutrophils across the vascular endothelium. Previously, we identified protein kinase C δ as a critical regulator of neutrophil migration in sepsis but did not identify sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab46a2d4809c19fc6779da38f5c0b91c
https://doi.org/10.1189/jlb.3ma0216-087r
https://doi.org/10.1189/jlb.3ma0216-087r
Publikováno v:
Drug Development Research. 75:497-509
Preclinical Research Phenylmethimazole (C10) is an inhibitor of Toll-like receptor (TLR3 and TLR4) expression and signaling. In this study, we carried out a detailed investigation of the effect of C10 on TLR4 and its molecular signaling products in R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48a6dea0c6f3d6b5b43e832d18e3a96b
https://doi.org/10.1002/ddr.21231
https://doi.org/10.1002/ddr.21231
Publikováno v:
Annals of Biomedical Engineering. 39:2627-2636
Pathological inflammation and endothelial dysfunction in atherosclerosis causes endothelial cell detachment from affected vasculature giving rise to circulating endothelial cells (CECs). A blood-based assay that can detect and characterize CECs in at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b275a38cb24e8452a73ff144dea48c58
https://doi.org/10.1007/s10439-011-0354-x
https://doi.org/10.1007/s10439-011-0354-x
Publikováno v:
Biotechnology and Bioengineering. 101:400-407
The increased expression of VCAM-1 on endothelial segments within plaque regions could be used as a target to deliver polymeric drug carriers selectively to sites of atherosclerosis. We probed the hypothesis that polymeric particles conjugated with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df252108fc71397808f1213b9d172b43
https://doi.org/10.1002/bit.21885
https://doi.org/10.1002/bit.21885
Autor:
Mohammad F. Kiani, Jenna Rosanno, Brian Augeli, Sudhir P. Deosarkar, Balabhaskar Prabhakarpandian, Barbara Krynska
Publikováno v:
The FASEB Journal. 29
Currently, there is a lack of a good experimental in vitro model for mimicking the blood brain barrier (BBB) to study the mechanisms of BBB permeability and to screen brain-penetrating therapeutics. We have developed a physiologically realistic in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc7795ec7b1f3b1f64168aa8a82e828f
https://doi.org/10.1096/fasebj.29.1_supplement.780.5
https://doi.org/10.1096/fasebj.29.1_supplement.780.5
Autor:
Douglas J. Goetz, Sudhir P. Deosarkar, Chunyan Qi, Monica M. Burdick, Frank L. Schwartz, Anuja Alapati, Grady E. Carlson, Olivia L. Lanier, Kelly D. McCall, Stephen C. Bergmeier
The expression of vascular cell adhesion molecule-1 (VCAM-1) on the vascular endothelium can be increased by pro-inflammatory cytokines [e.g. tumor necrosis factor – α (TNF-α)]. VCAM-1 contributes to leukocyte adhesion to, and emigration from, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66e93ecb177eb8c07cb2a2737da0e38
https://europepmc.org/articles/PMC5019189/
https://europepmc.org/articles/PMC5019189/
