Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Sudhir Marathe"'
1
Novel loci interacting epistatically with bone morphogenetic protein receptor 2 cause familial pulmonary arterial hypertension
Autor: Robyn J. Barst, Wendy K. Chung, Sudhir Marathe, Sreemanta Pramanik, William C.L. Stewart, David A. Greenberg, Ryan L. Subaran, Laura Rodriguez-Murillo
Publikováno v: The Journal of Heart and Lung Transplantation. 29:174-180
Background Familial pulmonary arterial hypertension (FPAH) is a rare, autosomal-dominant, inherited disease with low penetrance. Mutations in the bone morphogenetic protein receptor 2 ( BMPR2 ) have been identified in at least 70% of FPAH patients. H
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19db31a40f625ce825ee28617ec8accf
https://doi.org/10.1016/j.healun.2009.08.022
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2
Sphingomyelinase Converts Lipoproteins From Apolipoprotein E Knockout Mice Into Potent Inducers of Macrophage Foam Cell Formation
Autor: Sudhir Marathe, Ira Tabas, Yunsook Choi, Andrew R. Leventhal
Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 20:2607-2613
Abstract —The apoE knockout (E0) mouse is one of the most widely used animal models of atherosclerosis, and there may be similarities to chylomicron remnant–induced atherosclerosis in humans. Although the lesions of these mice contain large numbe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad9d58dadaff5cdf975dbcbb2c32764
https://doi.org/10.1161/01.atv.20.12.2607
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3
Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo : A possible link between inflammatory cytokines and atherogenesis
Autor: Ma-Li Wong, Philip W. Gold, Ira Tabas, Kevin Jon Williams, Anthony Johns, Phan Phu, Sudhir Marathe, Nan Beatini, Emmet Hirsch, Boxun Xie, Julio Licinio
Publikováno v: Proceedings of the National Academy of Sciences. 97:8681-8686
Inflammation plays a critical role in atherogenesis, yet the mediators linking inflammation to specific atherogenic processes remain to be elucidated. One such mediator may be secretory sphingomyelinase (S-SMase), a product of the acid sphingomyelina
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a5641b5581c39cd6bc1d3c07f9fa28
https://doi.org/10.1073/pnas.150098097
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4
Multiple Forms of Arginase Are Differentially Expressed from a Single Locus in Neurospora crassa
Autor: Gloria E. Turner, Yeon Gyu Yu, Sudhir Marathe, Richard L. Weiss, Christine Palmier
Publikováno v: Journal of Biological Chemistry. 273:29776-29785
The Neurospora crassa catabolic enzyme, arginase (l-arginine amidinohydrolase, EC 3.5.3.1), exists in multiple forms. Multiple forms of arginase are found in many vertebrates, but this is the only reported example in a microbial organism. The two maj
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26c7fa88ef7966c9703a84bcc2a6f3e
https://doi.org/10.1074/jbc.273.45.29776
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5
Human Vascular Endothelial Cells Are a Rich and Regulatable Source of Secretory Sphingomyelinase
Autor: Nanda Beatini, Ira Tabas, Sudhir Marathe, Kevin Jon Williams, Michael J. Yellin, Scott L. Schissel, Robert Mintzer
Publikováno v: Journal of Biological Chemistry. 273:4081-4088
We recently reported that macrophages and fibroblasts secrete a Zn2+-dependent sphingomyelinase (S-SMase), which, like lysosomal SMase, is a product of the acid SMase gene. S-SMase may cause subendothelial retention and aggregation of lipoproteins du
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfc3bce27f07640f93e099a8587d6b46
https://doi.org/10.1074/jbc.273.7.4081
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6
Evidence That the Initial Up-regulation of Phosphatidylcholine Biosynthesis in Free Cholesterol-loaded Macrophages Is an Adaptive Response That Prevents Cholesterol-induced Cellular Necrosis
Autor: Sudhir Marathe, Yoshimune Shiratori, Nanda Beatini, Ira Tabas, George A. Keesler
Publikováno v: Journal of Biological Chemistry. 271:22773-22781
Macrophages in atherosclerotic lesions accumulate free cholesterol (FC) as well as cholesteryl ester and appear to have high rates of phospholipid (PL) synthesis and increased PL mass. Previous short term (i.e. ≤24 h) studies with cultured macropha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9de41567bd47e5816b861ceb09494441
https://doi.org/10.1074/jbc.271.37.22773
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7
Construction of the model for the Genetic Analysis Workshop 14 simulated data: genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium, and ascertainment effects for a complex phenotype
Autor: Lisa J. Strug, David A. Greenberg, Dvora Shmulewitz, Junying Zhang, Regina Zimmerman, Sudhir Marathe, Veena M. Singh
Publikováno v: BMC Genetics, Vol 6, Iss Suppl 1, p S3 (2005)
BMC Genetics
The Genetic Analysis Workshop 14 simulated dataset was designed 1) To test the ability to find genes related to a complex disease (such as alcoholism). Such a disease may be given a variety of definitions by different investigators, have associated e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afddaef172eb78a271e9b68de4201a6
http://www.gaworkshop.org/
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