Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sudhir B Malla"'
Autor:
Courtney Bull, Ryan M. Byrne, Natalie C. Fisher, Shania M. Corry, Raheleh Amirkhah, Jessica Edwards, Lily V. S. Hillson, Mark Lawler, Aideen E. Ryan, Felicity Lamrock, Philip D. Dunne, Sudhir B. Malla
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Gene set enrichment analysis (GSEA) tools can identify biological insights within gene expression-based studies. Although their statistical performance has been compared, the downstream biological implications that arise when choosing betwee
Externí odkaz:
https://doaj.org/article/386084e66db44aa6a12bb7869e4d5cf5
Autor:
Shun Hay Pun, Karla M. O’Neill, Kevin S. Edgar, Eleanor K. Gill, Arya Moez, Hojjat Naderi-Meshkin, Sudhir B. Malla, Michelle B. Hookham, Mohammed Alsaggaf, Vinuthna Vani Madishetti, Bianca Botezatu, William King, Coy Brunssen, Henning Morawietz, Philip D. Dunne, Derek P. Brazil, Reinhold J. Medina, Chris J. Watson, David J. Grieve
Publikováno v:
Cells, Vol 12, Iss 18, p 2220 (2023)
Ischaemic cardiovascular disease is associated with tissue hypoxia as a significant determinant of angiogenic dysfunction and adverse remodelling. While cord blood-derived endothelial colony-forming cells (CB-ECFCs) hold clear therapeutic potential d
Externí odkaz:
https://doaj.org/article/c401b027209144cda01f2bdf818f87be
Autor:
Baharak Ahmaderaghi, Raheleh Amirkhah, James Jackson, Tamsin R. M. Lannagan, Kathryn Gilroy, Sudhir B. Malla, Keara L. Redmond, Gerard Quinn, Simon S. McDade, ACRCelerate Consortium, Tim Maughan, Simon Leedham, Andrew S. D. Campbell, Owen J. Sansom, Mark Lawler, Philip D. Dunne
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 3 (2022)
Generation of transcriptional data has dramatically increased in the past decade, driving the development of analytical algorithms that enable interrogation of the biology underpinning the profiled samples. However, these resources require users to h
Externí odkaz:
https://doaj.org/article/af0348220b314b64a6a61c4ef7c86992
Autor:
Philip D. Dunne, Louise C. Brown, Timothy S. Maughan, Mark Lawler, Daniel B. Longley, Richard S. Kaplan, Letitia Campo, Viktor H. Koelzer, Ian Tomlinson, Patrick G. Johnston, Richard D. Kennedy, Manuel Salto-Tellez, Nicholas P. West, Philip Quirke, Dion G. Morton, Matthew T. Seymour, Ultan McDermott, Stephanie G. Craig, Matthew P. Humphries, Raheleh Amirkhah, Aikaterina Chatzipli, Gemma E. Logan, Steven M. Walker, Michael Youdell, Susan D. Richman, Keara L. Redmond, Sylvana Hassanieh, Andrew Blake, Enric Domingo, David J. Fisher, Sudhir B. Malla
Purpose:The DNA damage immune response (DDIR) assay was developed in breast cancer based on biology associated with deficiencies in homologous recombination and Fanconi anemia pathways. A positive DDIR call identifies patients likely to respond to pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b0d147fbbb30b1796bb72b6461704c
https://doi.org/10.1158/1078-0432.c.6530324.v1
https://doi.org/10.1158/1078-0432.c.6530324.v1
Autor:
Philip D. Dunne, Louise C. Brown, Timothy S. Maughan, Mark Lawler, Daniel B. Longley, Richard S. Kaplan, Letitia Campo, Viktor H. Koelzer, Ian Tomlinson, Patrick G. Johnston, Richard D. Kennedy, Manuel Salto-Tellez, Nicholas P. West, Philip Quirke, Dion G. Morton, Matthew T. Seymour, Ultan McDermott, Stephanie G. Craig, Matthew P. Humphries, Raheleh Amirkhah, Aikaterina Chatzipli, Gemma E. Logan, Steven M. Walker, Michael Youdell, Susan D. Richman, Keara L. Redmond, Sylvana Hassanieh, Andrew Blake, Enric Domingo, David J. Fisher, Sudhir B. Malla
Supplementary Results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9837817e7906381d03da436c4c0aba83
https://doi.org/10.1158/1078-0432.22479923
https://doi.org/10.1158/1078-0432.22479923
Autor:
Philip D. Dunne, Nigel B. Jamieson, Viktor H. Koelzer, Felicity Lamrock, Owen J. Sansom, Mark Lawler, Tim Maughan, Simon Leedham, Maurice B. Loughrey, James Jackson, Enric Domingo, Svetlana Sakhnevych, Keara L. Redmond, Emily Rogan, Aoife J. McCooey, Raheleh Amirkhah, Sudhir B. Malla, Shania M. Corry, Baharak Ahmaderaghi, Andrew J. Cameron, Assya Legrini, Colin Wood, Holly Leslie, Ryan M. Byrne, Natalie C. Fisher
Supplementary Figure from Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0771c16776581bd680a135636aaa9b65
https://doi.org/10.1158/1078-0432.22487885
https://doi.org/10.1158/1078-0432.22487885
Autor:
Philip D. Dunne, Nigel B. Jamieson, Viktor H. Koelzer, Felicity Lamrock, Owen J. Sansom, Mark Lawler, Tim Maughan, Simon Leedham, Maurice B. Loughrey, James Jackson, Enric Domingo, Svetlana Sakhnevych, Keara L. Redmond, Emily Rogan, Aoife J. McCooey, Raheleh Amirkhah, Sudhir B. Malla, Shania M. Corry, Baharak Ahmaderaghi, Andrew J. Cameron, Assya Legrini, Colin Wood, Holly Leslie, Ryan M. Byrne, Natalie C. Fisher
Purpose:Precise mechanism-based gene expression signatures (GES) have been developed in appropriate in vitro and in vivo model systems, to identify important cancer-related signaling processes. However, some GESs originally developed to represent spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bff0c77fa2f9744a83b0b46f002ba71
https://doi.org/10.1158/1078-0432.c.6532604.v1
https://doi.org/10.1158/1078-0432.c.6532604.v1
Autor:
Philip D. Dunne, Louise C. Brown, Timothy S. Maughan, Mark Lawler, Daniel B. Longley, Richard S. Kaplan, Letitia Campo, Viktor H. Koelzer, Ian Tomlinson, Patrick G. Johnston, Richard D. Kennedy, Manuel Salto-Tellez, Nicholas P. West, Philip Quirke, Dion G. Morton, Matthew T. Seymour, Ultan McDermott, Stephanie G. Craig, Matthew P. Humphries, Raheleh Amirkhah, Aikaterina Chatzipli, Gemma E. Logan, Steven M. Walker, Michael Youdell, Susan D. Richman, Keara L. Redmond, Sylvana Hassanieh, Andrew Blake, Enric Domingo, David J. Fisher, Sudhir B. Malla
Figures S1-S9, Tables S1, S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496cf180498237ddd1cd669c0717922a
https://doi.org/10.1158/1078-0432.22479920
https://doi.org/10.1158/1078-0432.22479920
Autor:
Philip D. Dunne, Nigel B. Jamieson, Viktor H. Koelzer, Felicity Lamrock, Owen J. Sansom, Mark Lawler, Tim Maughan, Simon Leedham, Maurice B. Loughrey, James Jackson, Enric Domingo, Svetlana Sakhnevych, Keara L. Redmond, Emily Rogan, Aoife J. McCooey, Raheleh Amirkhah, Sudhir B. Malla, Shania M. Corry, Baharak Ahmaderaghi, Andrew J. Cameron, Assya Legrini, Colin Wood, Holly Leslie, Ryan M. Byrne, Natalie C. Fisher
Supplementary Table from Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c604bfda44bbf353c1d284827d4f897
https://doi.org/10.1158/1078-0432.22487879
https://doi.org/10.1158/1078-0432.22487879
Autor:
Philip D. Dunne, Louise C. Brown, Timothy S. Maughan, Mark Lawler, Daniel B. Longley, Richard S. Kaplan, Letitia Campo, Viktor H. Koelzer, Ian Tomlinson, Patrick G. Johnston, Richard D. Kennedy, Manuel Salto-Tellez, Nicholas P. West, Philip Quirke, Dion G. Morton, Matthew T. Seymour, Ultan McDermott, Stephanie G. Craig, Matthew P. Humphries, Raheleh Amirkhah, Aikaterina Chatzipli, Gemma E. Logan, Steven M. Walker, Michael Youdell, Susan D. Richman, Keara L. Redmond, Sylvana Hassanieh, Andrew Blake, Enric Domingo, David J. Fisher, Sudhir B. Malla
supplementary methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3561136117c96a00b0726edbd0837c50
https://doi.org/10.1158/1078-0432.22479926.v1
https://doi.org/10.1158/1078-0432.22479926.v1