Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sudharshan Hariharan"'
Autor:
Thomas R. Fleming, Christine E. Garnett, Laurie S. Conklin, Solange Corriol-Rohou, Sudharshan Hariharan, Daphne Hsu, Guenther Mueller-Velten, Yeruk Mulugeta, Ronald Portman, Mark D. Rothmann, Norman L. Stockbridge, Simon Wandel, Jialu Zhang, Lynne Yao
Publikováno v:
Therapeutic innovationregulatory science. 57(1)
Even with recent substantive improvements in health care in pediatric populations, considerable need remains for additional safe and effective interventions for the prevention and treatment of diseases in children. The approval of prescription drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40989891b158eea2f9b1ca62e1fb45f
https://pubmed.ncbi.nlm.nih.gov/36057747
https://pubmed.ncbi.nlm.nih.gov/36057747
Publikováno v:
Ophthalmology and Eye Diseases, Vol 2009, Iss 1, Pp 21-31 (2009)
Objective: To delineate the plasma pharmacokinetics and determine the corneal uptake of valine based stereoisomeric dipeptide prodrugs of acyclovir (ACV) in rats. Methods: Male Sprague-Dawley rats were used for the study. Pharmacokinetics of ACV, L-v
Externí odkaz:
https://doaj.org/article/68eef9ebbed647cd9c51195d698f1c50
Autor:
Gowraganahalli Jagadeesh, Mohan K. Sapru, Tzu-Yun McDowell, Ququan Liu, Norman Stockbridge, Sudharshan Hariharan, Venkateswaran C Pillai, Martin Rose, Fortunato Senatore, Mary Ross Southworth
Publikováno v:
American Journal of Cardiovascular Drugs. 19:11-20
Distributive shock is a subset of shock marked by decreased systemic vascular resistance, organ hypoperfusion and altered oxygen extraction. Despite the use of intravenous fluids and either higher dose of catecholamines or other additional exogenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aeacd0d55121d3e3ea13f19bd62976f
https://doi.org/10.1007/s40256-018-0297-9
https://doi.org/10.1007/s40256-018-0297-9
Autor:
R. Angelo de Claro, Richard Pazdur, Nicholas Richardson, Chao Liu, Gregory H. Reaman, Margret Merino, Anusha Ande, Simbarashe Zvada, Sudharshan Hariharan, Ann T. Farrell
Publikováno v:
Pediatric bloodcancerREFERENCES. 67(12)
On May 16, 2019, the U.S. Food and Drug Administration (FDA) approved dalteparin sodium for the treatment of symptomatic venous thromboembolism (VTE) to reduce the risk of recurrence in pediatric patients 1 month of age and older. Approval was primar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd9da2262ab26620bd76ee3eff7dd80
https://pubmed.ncbi.nlm.nih.gov/32969168
https://pubmed.ncbi.nlm.nih.gov/32969168
Publikováno v:
The Journal of Clinical Pharmacology. 54:884-888
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe54e37e53fe44dfc9a83739f649060
https://doi.org/10.1002/jcph.337
https://doi.org/10.1002/jcph.337
Publikováno v:
AAPS PharmSciTech. 15:1454-1467
The purpose of this study was to develop a clear aqueous mixed nanomicellar formulation (MNF) of dexamethasone utilizing both D-α-tocopherol polyethylene glycol-1000 succinate (Vit E TPGS) and octoxynol-40 (Oc-40). In this study, Vit E TPGS and Oc-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e2171d3214b6a836e8a5dd5d9ef695
https://doi.org/10.1208/s12249-014-0159-y
https://doi.org/10.1208/s12249-014-0159-y
Autor:
Jwala Jwala, Sudharshan Hariharan, Sai H.S. Boddu, Ashim K. Mitra, Ravinder Earla, Kishore Cholkar
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 52:525-533
A sensitive, selective, accurate and robust LC-MS/MS method was developed and validated for the quantitative determination of glucocorticoids in rabbit ocular tissues. Samples were processed by a simple liquid- liquid extraction procedure. Chromatogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d14ec493912e468087a9540de62f21
https://doi.org/10.1016/j.jpba.2010.01.015
https://doi.org/10.1016/j.jpba.2010.01.015
Publikováno v:
Clinical Research and Regulatory Affairs. 26:65-72
The objective of this work was to study the disposition kinetics of valine-valine-acyclovir (VVACV), a dipeptide ester prodrug of acyclovir following intravenous and oral administrations in rat. A validated LC-MS/MS analytical method was developed fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8cc4e2288af9f322900d698a275d8f
https://doi.org/10.1080/10601330903200684
https://doi.org/10.1080/10601330903200684
Publikováno v:
Pharmaceutical Research. 26:1270-1282
The objectives were (i) to test in vivo functional activity of MRP2 on rabbit corneal epithelium and (ii) to evaluate modulation of P-gp and MRP2 mediated efflux of erythromycin when co-administered with corticosteroids.Cultured rabbit primary cornea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca40fb8e66a4fb6a3ded156947d3c07
https://doi.org/10.1007/s11095-008-9741-x
https://doi.org/10.1007/s11095-008-9741-x
Publikováno v:
International Journal of Pharmaceutics. 362:93-101
In vivo systemic absorption of the amino acid prodrugs of acyclovir (ACV) after oral administration was evaluated in rats. Stability of the prodrugs, l -alanine-ACV (AACV), l -serine-ACV (SACV), l -isoleucine-ACV (IACV), γ-glutamate-ACV (EACV) and l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7cf0a35d8e9864e00714f75042cb8fc
https://doi.org/10.1016/j.ijpharm.2008.06.018
https://doi.org/10.1016/j.ijpharm.2008.06.018