Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Sudhakar Veeranki"'
Autor:
Santosh K Sanganalmath, Shubham Dubey, Sudhakar Veeranki, Keerthy Narisetty, Prasanna Krishnamurthy
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-22 (2023)
Abstract Diabetes mellitus is one of the prime risk factors for cardiovascular complications and is linked with high morbidity and mortality. Diabetic cardiomyopathy (DCM) often manifests as reduced cardiac contractility, myocardial fibrosis, diastol
Externí odkaz:
https://doaj.org/article/d40861dab903410eabe7c53c9d587c6b
Autor:
Sudhakar Veeranki, Suresh C. Tyagi
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 1, Pp 1252-1265 (2015)
Although hyperhomocysteinemia (HHcy) elicits lower than normal body weights and skeletal muscle weakness, the mechanisms remain unclear. Despite the fact that HHcy-mediated enhancement in ROS and consequent damage to regulators of different cellular
Externí odkaz:
https://doaj.org/article/2931b7af63ba47aa9a0d9a75bd7b1655
Autor:
Suresh C. Tyagi, Sudhakar Veeranki
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 7, Pp 15074-15091 (2013)
Hyperhomocysteinemia (HHcy) is a systemic medical condition and has been attributed to multi-organ pathologies. Genetic, nutritional, hormonal, age and gender differences are involved in abnormal homocysteine (Hcy) metabolism that produces HHcy. Homo
Externí odkaz:
https://doaj.org/article/689f66b462e2424e8a1bc74b54fe2a3b
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19532 (2011)
Glucose restriction in cells increases the AMP/ATP ratio (energetic stress), which activates the AMPK/p53 pathway. Depending upon the energetic stress levels, cells undergo either autophagy or cell death. Given that the activated p53 induces the expr
Externí odkaz:
https://doaj.org/article/350b9e45f0f64414a6a3476330ede661
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e27040 (2011)
Type-I interferons (IFNs) are used to treat certain inflammatory diseases. Moreover, activation of type-I IFN-signaling in immune cells inhibits the production of proinflammatory cytokines and activation of inflammasomes. However, the molecular mecha
Externí odkaz:
https://doaj.org/article/5ac4a9d27fd240d1925042a5d2693cc2
Autor:
Ming C. Gong, Douglas A. Andres, Mihir Shah, Nemat Ali, Brooke M. Ahern, Andrea Sebastian, Julian E. Stelzer, Jiayang Li, Jonathan Satin, Wen Su, Sudhakar Veeranki, Bryana M. Levitan
Publikováno v:
J Biol Chem
Existing therapies to improve heart function target β-adrenergic receptor (β-AR) signaling and Ca(2+) handling and often lead to adverse outcomes. This underscores an unmet need for positive inotropes that improve heart function without any adverse
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 95:239-246
Although hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular diseases (CVD), there is a debate on whether HHcy is a risk factor or just a biomarker. Interestingly, homocysteine lowering strategies in humans had very little ef
Autor:
Daheng He, Lyndsay E.A. Young, Tara R. Hawkinson, Chi Wang, Jonathan Satin, Sudhakar Veeranki, Bryana M. Levitan, Ramon C. Sun, Douglas A. Andres
Publikováno v:
J Biol Chem
MS-based metabolomics methods are powerful techniques to map the complex and interconnected metabolic pathways of the heart; however, normalization of metabolite abundance to sample input in heart tissues remains a technical challenge. Herein, we des
Autor:
Jonathan Satin, Nemat Ali, Julian E. Stelzer, Doug Andres, Andrea Sebastian, Mihir Shah, Sudhakar Veeranki, Jiayang Li, Bryana M. Levitan, Brooke M. Ahern
Publikováno v:
Circulation Research. 125
The L-type Ca 2+ channel current (I Ca,L ) provides trigger Ca 2+ to contribute to cardiac contraction. Rad GTPase associates with the L-type Ca 2+ channel (LTCC) and serves as an endogenous inhibitor of LTCC activity. Overexpression of Rad blocks I
Autor:
Naira Metreveli, Sathnur Pushpakumar, Srikanth Givvimani, Suresh C. Tyagi, Sudhakar Veeranki, Sourav Kundu
Publikováno v:
Journal of Molecular and Cellular Cardiology. 92:163-173
Aims Although the cardiovascular benefits of exercise are well known, exercise induced effects and mechanisms in prevention of cardiomyopathy are less clear during obesity associated type-2 diabetes. The current study assessed the impact of moderate