Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sudhakar Pai"'
Publikováno v:
Antimicrobial Agents and Chemotherapy. 47:2788-2795
The pharmacokinetics, safety, and tolerability of posaconazole, an investigational triazole antifungal, were evaluated following the administration of rising single and multiple oral doses. A total of 103 healthy adults were enrolled in two phase I t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d4eea51465691f7abc37e17e28607f6
https://doi.org/10.1128/aac.47.9.2788-2795.2003
https://doi.org/10.1128/aac.47.9.2788-2795.2003
Autor:
Sudhakar Pai, Cuss Francis M, Mark A. Wirth, Desmond Padhi, Josephine Lim, Melton B. Affrime, Robert P. Clement, Bhavna Kantesaria, Kevin B. Alton, Mitchell N. Cayen
Publikováno v:
The Journal of Clinical Pharmacology. 40:1227-1236
These studies were conducted to assess the systemic bioavailability of mometasone furoate (MF) administered by both the dry-powder inhaler (DPI) and the metered-dose inhaler with an alternate propellant (MDI-AP). The pharmacokinetics of single doses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f2bcb8fdcce50ab9bd5008dddb8b4e5
https://doi.org/10.1177/009127000004001107
https://doi.org/10.1177/009127000004001107
Autor:
Samuel Heft, Vijay Batra, Sudhakar Pai, J. Frank Jen, Melton B. Affrime, Demetris N. Zambas, Gerald Hajian, David L. Cutler
Publikováno v:
Pharmaceutical Research. 17:1284-1289
Purpose. To evaluate covariate effects on the pharmacokinetics of temozolomide in cancer patients, and to explore the dose-pharmacokinetics-toxicity relationship of temozolomide.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9005484cfbcfe53f70fde9d58f68b32
https://doi.org/10.1023/a:1026403805756
https://doi.org/10.1023/a:1026403805756
Autor:
Sudhakar Pai, Karen M. Walters, Christopher M. Banks, Elmer J. Mirro, J. Gregory Beattie, Janet M. Petruska, George W. Lulham, Bruce O. Stuart
Publikováno v:
Toxicological Sciences. 40:52-62
Albuterol is a quickly acting beta-2 adrenergic agonist bronchodilator widely used by asthmatics. Because recent case-control studies have suggested a relationship between the increase in mortality of asthmatics over the past decade and the use of be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2cc0127f2e4aaa981f1852a7533076
https://doi.org/10.1093/toxsci/40.1.52
https://doi.org/10.1093/toxsci/40.1.52
Publikováno v:
Pharmaceutical Research. 13:1283-1290
Purpose. The objective of this work was to develop and validate blood sampling schemes for accurate AUC determination from a few samples (sparse sampling). This will enable AUC determination directly in toxicology studies, without the need to utilize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4095609f64d5a368abe8c02b944b35c
https://doi.org/10.1023/a:1016097227603
https://doi.org/10.1023/a:1016097227603
Autor:
Gregory M. Kochak, Deborah Kachmar, Frank Honc, Peter J. Perrino, Hanspeter Egger, Robert Iannucci, Sudhakar Pai
Publikováno v:
Pharmaceutical Research. 10:49-55
Prinomide tromethamine, a nonsteroidal antiinflammatory drug, was orally administered at doses of 250, 500, and 1000 mg every 12 hr for 28 days to healthy male volunteers. The pharmacokinetic behavior of prinomide and its primary plasma metabolite di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3571a20bee21a500ad1fcf13a98b433b
https://doi.org/10.1023/a:1018916811904
https://doi.org/10.1023/a:1018916811904
Autor:
Robert D. Colucci, Christopher Banfield, W. Sulowicz, Sudhakar Pai, M.B. Affrime, Paul Glue, Chin-Chung Lin
Publikováno v:
Scopus-Elsevier
Aims The purpose of this study was to evaluate the effects of renal impairment on the single-dose pharmacokinetics of the antiepileptic felbamate. Methods Twelve subjects with three levels of renal dysfunction (creatinine clearance >30–80, >10–30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e105ad6e6432081779911f32ab8bf8
https://doi.org/10.1046/j.1365-2125.1997.00619.x
https://doi.org/10.1046/j.1365-2125.1997.00619.x
Publikováno v:
Pharmaceutical Research. 13:1280-1282
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee62f7d8a2cae13f896069d1a32875f0
https://doi.org/10.1023/a:1016045210765
https://doi.org/10.1023/a:1016045210765
Publikováno v:
European journal of clinical pharmacology. 48(5)
SCH 42354, a neutral metalloendopeptidase (NEP) inhibitor, is the pharmacologically active form of the prodrug SCH 42495. It exerts antihypertensive effects by potentiating atrial natriuretic peptide (ANP) activity through inhibition of its hydrolysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a1b378937b79294fb9499f550319f9
https://pubmed.ncbi.nlm.nih.gov/8641322
https://pubmed.ncbi.nlm.nih.gov/8641322
Autor:
Chin-Chung Lin, Pascale Reidenberg, W. Sulowicz, Jeffrey W. Meehan, D.P. Glue, Robert D. Colucci, M.B. Affrime, Christopher Banfield, Sudhakar Pai
Publikováno v:
Clinical Pharmacology & Therapeutics. 59:185-185
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd8200510fe8706b205ec429fcf86de4
https://doi.org/10.1038/clpt.1996.240
https://doi.org/10.1038/clpt.1996.240