Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sudhakar Manda"'
Publikováno v:
Molecules, Vol 25, Iss 8, p 1948 (2020)
A focused PROTAC library was developed to degrade both IGF-1R and Src proteins, which are associated with various cancers. PROTACs with IGF-1R and Src degradation potentials were synthesized by tethering different inhibitor warhead units and the E3 l
Externí odkaz:
https://doaj.org/article/2c322b5f6c81432d978ffe6bae23002d
Autor:
Sandip Bibishan Bharate, Nagaraju Mupparapu, Sudhakar Manda, Jaideep B. Bharate, Ramesh Mudududdla, Rammohan R. Yadav, Ram A. Vishwakarma
Publikováno v:
ARKIVOC, Vol 2012, Iss 8, Pp 308-318 (2012)
Externí odkaz:
https://doaj.org/article/e1738c8a228346cf8c02116e1d9ece5b
Autor:
Santosh Kumar Guru, Shashi Bhushan, Venna Deva Prasad, Mubashir J. Mintoo, Ashok Kumar, Sonia Sharma, Parduman R. Sharma, Sudhakar Manda, Sandip B. Bharate, Dilip M. Mondhe
Publikováno v:
Chemico-Biological Interactions. 275:47-60
Tumor angiogenesis and PI3K/Akt/mTOR pathway are two major molecular objectives for the treatment and management of breast cancer. Here we first time report the molecular mechanism of a marine sponge alkaloid derivative 4-chloro fascapysin (4-CF) for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15c9570e0b4b5b9552d145defeec31e
https://doi.org/10.1016/j.cbi.2017.07.017
https://doi.org/10.1016/j.cbi.2017.07.017
Autor:
Shashi Bhushan, Sudhakar Manda, Abubakar Wani, Vikas Kumar, Sadhana Sharma, Ram A. Vishwakarma, Santosh Kumar Guru, Sonali S. Bharate, Sandip B. Bharate, Prashant Joshi, Ajay Kumar
Publikováno v:
European Journal of Medicinal Chemistry. 107:1-11
The screening of IIIM natural products repository for P-gp modulatory activity in P-gp over-expressing human adenocarcinoma LS-180 cells led to the identification of 7 natural products viz. withaferin, podophyllotoxin, 3-demethylcolchicine, agnuside,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb02d0362411462a8ca17583281c4fa
https://doi.org/10.1016/j.ejmech.2015.10.049
https://doi.org/10.1016/j.ejmech.2015.10.049
Autor:
Sudhakar Manda, Sonali S. Bharate, Abubakar Wani, Ram A. Vishwakarma, Ajay Kumar, Sandip B. Bharate
Publikováno v:
MedChemComm. 7:1910-1915
The clearance of amyloid-beta is mediated by the P-glycoprotein (P-gp) transporter pump located at the blood brain barrier. Therefore, the induction of P-gp has been considered as a potential therapeutic strategy for the treatment of Alzheimer's dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fcddb536bcd0b6478cf6c88d8876792
https://doi.org/10.1039/c6md00300a
https://doi.org/10.1039/c6md00300a
Publikováno v:
Molecules
Volume 25
Issue 8
Molecules, Vol 25, Iss 1948, p 1948 (2020)
Volume 25
Issue 8
Molecules, Vol 25, Iss 1948, p 1948 (2020)
A focused PROTAC library was developed to degrade both IGF-1R and Src proteins, which are associated with various cancers. PROTACs with IGF-1R and Src degradation potentials were synthesized by tethering different inhibitor warhead units and the E3 l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7a81c68d55659d3e14103dbda64730
https://doi.org/10.3390/molecules25081948
https://doi.org/10.3390/molecules25081948
Autor:
Ajay Kumar, Santosh Kumar Guru, Fayaz Malik, Sudhakar Manda, Ram A. Vishwakarma, Suresh Kumar, Sandip B. Bharate, Shashi Bhushan, Anup Singh Pathania
Publikováno v:
Journal of Cellular Biochemistry. 116:985-997
In this study, we for the first time explored the cellular and molecular mechanism of anticancer properties of fascaplysin, a marine sponge-derived alkaloid. Our study demonstrated that fascaplysin induced a cooperative interaction between apoptotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1666961fa4cc0223547c2c6162acc59a
https://doi.org/10.1002/jcb.25053
https://doi.org/10.1002/jcb.25053
Autor:
Ram A. Vishwakarma, Rammohan R. Yadav, Sandip B. Bharate, Jaideep B. Bharate, Sudhakar Manda, Ramesh Mudududdla, Nagaraju Mupparapu
Publikováno v:
ARKIVOC, Vol 2012, Iss 8, Pp 308-318 (2012)
The heterogeneous solid acid catalysts Amberlyst-15 and silica-HClO 4 displays efficient catalytic properties for the synthesis of 2,3-dihydroquinazolin-4( 1H )-ones from anthranilamide and various aldehydes/ ketones under mild reaction conditions an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14887a5a0bdd6263e2c1e40bb7728bf
https://doi.org/10.3998/ark.5550190.0013.826
https://doi.org/10.3998/ark.5550190.0013.826
Autor:
Prabir Mukherjee, Shalabh P. Bharadwaj, Taniya Ray, Siva Subramanian, Sudhakar Manda, I. V. Ramanuja Rao
Publikováno v:
Journal of Bamboo and Rattan. 2:453-461
The North-Eastern region of India is endowed with rich bio-diversity. The total forest cover in the region is around 60% of the total geographical area. Bamboo accounts for approximately 7% percent of the total forest cover of the region [1]. Due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73228d8d823ab0bc55b6916cd8dbe134
https://doi.org/10.1163/156915903322700476
https://doi.org/10.1163/156915903322700476
Autor:
Bhabatosh Chaudhuri, Paul R. Jenkins, Prashant Joshi, Sudhakar Manda, Sachin Mahale, Sandip B. Bharate, Ram A. Vishwakarma
Publikováno v:
Cell Death & Disease
The marine natural product fascaplysin (1) is a potent Cdk4 (cyclin-dependent kinase 4)-specific inhibitor, but is toxic to all cell types possibly because of its DNA-intercalating properties. Through the design and synthesis of numerous fascaplysin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9198dc252545091b66fbe6db1b4e5e3b
https://pubmed.ncbi.nlm.nih.gov/25950473
https://pubmed.ncbi.nlm.nih.gov/25950473