Výsledky vyhledávání - "Sudha Thoennes"

Single residue deletions along the length of the influenza HA fusion peptide lead to inhibition of membrane fusion function

Autor: William A. Langley, E. Varečková, Ru Pert J. Russell, Konrad C. Bradley, Summer E. Galloway, Sudha Thoennes, Sandra F. Cummings, David A. Steinhauer, Ganesh R. Talekar

Publikováno v: Virology. 394:321-330

A panel of eight single amino acid deletion mutants was generated within the first 24 residues of the fusion peptide domain of the of the hemagglutinin (HA) of A/Aichi/2/68 influenza A virus (H3N2 subtype). The mutant HAs were analyzed for folding, c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e7c5d3d474d3ae9ff2eb2e96059ebd
https://doi.org/10.1016/j.virol.2009.08.031

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Infectivity Studies of Influenza Virus Hemagglutinin Receptor Binding Site Mutants in Mice

Autor: Jeffrey Meisner, Konrad C. Bradley, Zhu-Nan Li, Javier Martin, Byeong-Jae Lee, John J. Skehel, Jacqueline M. Katz, David A. Steinhauer, Kristy J. Szretter, Sudha Thoennes, William A. Langley, Rupert J. Russell

Publikováno v: Journal of Virology. 82:5079-5083

The replicative properties of influenza virus hemagglutinin (HA) mutants with altered receptor binding characteristics were analyzed following intranasal inoculation of mice. Among the mutants examined was a virus containing a Y98F substitution at a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35ac63ad50073423ce6521fca95878e
https://doi.org/10.1128/jvi.01958-07

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Analysis of residues near the fusion peptide in the influenza hemagglutinin structure for roles in triggering membrane fusion

Autor: Sudha Thoennes, John J. Skehel, William A. Langley, David A. Steinhauer, Byeong-Jae Lee, Zhu-Nan Li, Rupert J. Russell

Publikováno v: Virology. 370:403-414

Influenza virus entry occurs in endosomes, where acidification triggers irreversible conformational changes of the hemagglutinin glycoprotein (HA) that are required for membrane fusion. The acid-induced HA structural rearrangements have been well doc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c79f4b05246e608da08bc5f511d122
https://doi.org/10.1016/j.virol.2007.08.035

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